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XRCC3 XRCC3 SLX4 SLX4 ENSCSAP00000007123 ENSCSAP00000007123 RAD51AP1 RAD51AP1 EME2 EME2 NBN NBN RAD51B RAD51B RAD50 RAD50 SPIDR SPIDR WRN WRN BLM BLM RBBP8 RBBP8 BRCA2 BRCA2 BRCA1 BRCA1 MRE11 MRE11 RTEL1 RTEL1 ATM ATM ENSCSAP00000017472 ENSCSAP00000017472 RMI1 RMI1 EME1 EME1 RAD51C RAD51C BRIP1 BRIP1 SLX1 SLX1 RAD51D RAD51D XRCC2 XRCC2 PALB2 PALB2 RAD51 RAD51 DNA2 DNA2 GEN1 GEN1 KAT5 KAT5 TOP3A TOP3A RECQL4 RECQL4 RMI2 RMI2 BARD1 BARD1 EXO1 EXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
SLX4Uncharacterized protein. (929 aa)
ENSCSAP00000007123RAD51_interact domain-containing protein. (319 aa)
RAD51AP1RAD51 associated protein 1. (354 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (383 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
RAD51BRAD51 paralog B. (265 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
SPIDRScaffold protein involved in DNA repair. (939 aa)
WRNWRN RecQ like helicase. (1399 aa)
BLMBLM RecQ like helicase. (1423 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
BRCA1Uncharacterized protein. (663 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1406 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
ENSCSAP00000017472ERCC4 domain-containing protein. (551 aa)
RMI1RecQ mediated genome instability 1. (625 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
RAD51CRAD51 paralog C. (367 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1248 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
PALB2Partner and localizer of BRCA2. (1183 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (907 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (522 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1000 aa)
RECQL4RecQ like helicase 4. (1210 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
EXO1Exonuclease 1. (845 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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