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| | LOC103221971 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | ENSCSAP00000000080 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa) |
| | RNF169 | Ring finger protein 169. (486 aa) |
| | POLD3 | Uncharacterized protein. (466 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | SUMO2 | Small ubiquitin-related modifier. (95 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (314 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | KXD1 | KxDL motif containing 1. (176 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | RAD51C | RAD51 paralog C. (367 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1248 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa) |
| | LIG3 | DNA ligase. (1009 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4834 aa) |
| | ENSCSAP00000002816 | MPN domain-containing protein. (320 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1183 aa) |
| | ENSCSAP00000003124 | BTB domain-containing protein. (463 aa) |
| | POLQ | DNA polymerase theta. (2729 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (522 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1000 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (735 aa) |
| | RECQL4 | RecQ like helicase 4. (1210 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1964 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | LOC103232514 | RING-type domain-containing protein. (190 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (718 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | ENSCSAP00000005631 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | ENSCSAP00000005636 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | H2BW2 | H2B histone family member M; Belongs to the histone H2B family. (175 aa) |
| | EXO1 | Exonuclease 1. (845 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | SLX4 | Uncharacterized protein. (929 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (501 aa) |
| | ENSCSAP00000007055 | Uncharacterized protein. (251 aa) |
| | ENSCSAP00000007123 | RAD51_interact domain-containing protein. (319 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (354 aa) |
| | MEIOB | Meiosis specific with OB-fold. (472 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (383 aa) |
| | PPP4R2 | Uncharacterized protein. (417 aa) |
| | ENSCSAP00000007698 | MPN domain-containing protein. (285 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (411 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (636 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | RAD51B | RAD51 paralog B. (265 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | ENSCSAP00000010000 | Uncharacterized protein. (254 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (532 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | ABL1 | Tyrosine-protein kinase. (1130 aa) |
| | ENSCSAP00000010913 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (939 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | POLK | DNA polymerase kappa. (847 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | ATRIP | ATR interacting protein. (790 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | WRN | WRN RecQ like helicase. (1399 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) |
| | ENSCSAP00000012217 | Uncharacterized protein. (293 aa) |
| | PARP1 | Poly(ADP-ribose) polymerase 1. (709 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1406 aa) |
| | PARP2 | Poly(ADP-ribose) polymerase 2. (570 aa) |
| | RFC1 | Replication factor C subunit 1. (985 aa) |
| | BLM | BLM RecQ like helicase. (1423 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (280 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3420 aa) |
| | RFC2 | Replication factor C subunit 2. (353 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (633 aa) |
| | BRCA1 | Uncharacterized protein. (663 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | CHEK1 | Checkpoint kinase 1. (749 aa) |
| | SIRT7 | Sirtuin 7. (400 aa) |
| | POLD1 | DNA polymerase. (1086 aa) |
| | UBC | Uncharacterized protein. (228 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa) |
| | ENSCSAP00000016536 | Uncharacterized protein. (286 aa) |
| | ENSCSAP00000016924 | Uncharacterized protein. (199 aa) |
| | CLSPN | Uncharacterized protein. (1132 aa) |
| | ENSCSAP00000017472 | ERCC4 domain-containing protein. (551 aa) |
| | ENSCSAP00000017561 | Uncharacterized protein. (294 aa) |
| | ENSCSAP00000017575 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSCSAP00000017611 | Uncharacterized protein. (295 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | LOC103229948 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCSAP00000017749 | Small ubiquitin-related modifier. (103 aa) |
| | ENSCSAP00000017765 | Ubiquitin-like domain-containing protein. (155 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | LOC103222584 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | ENSCSAP00000018107 | Uncharacterized protein. (295 aa) |
| | ENSCSAP00000018240 | Uncharacterized protein. (294 aa) |
| | ENSCSAP00000018444 | Ubiquitin-like domain-containing protein. (127 aa) |
| | HIST1H2BO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103221972 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC4 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
