STRINGSTRING
POLN POLN FANCM FANCM FANCB FANCB WDR48 WDR48 FANCL FANCL RPS27A RPS27A UBE2T UBE2T NUTF2 NUTF2 FAAP24 FAAP24 DCLRE1A DCLRE1A UBA52 UBA52 KXD1 KXD1 EME1 EME1 SLX1 SLX1 FANCC FANCC FAN1 FAN1 ERCC4 ERCC4 SLX4 SLX4 FANCE FANCE FANCD2 FANCD2 FANCG FANCG MEIOB MEIOB ATR ATR EME2 EME2 RPA1 RPA1 RPA3 RPA3 FANCF FANCF ENSCSAP00000018444 ENSCSAP00000018444 ENSCSAP00000017765 ENSCSAP00000017765 ENSCSAP00000017575 ENSCSAP00000017575 ENSCSAP00000017472 ENSCSAP00000017472 ENSCSAP00000017299 ENSCSAP00000017299 USP1 USP1 DCLRE1B DCLRE1B UBC UBC ENSCSAP00000015863 ENSCSAP00000015863 FANCA FANCA ERCC1 ERCC1 PROSER1 PROSER1 FANCI FANCI ATRIP ATRIP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLNDNA polymerase nu. (663 aa)
FANCMFA complementation group M. (2050 aa)
FANCBFA complementation group B. (859 aa)
WDR48WD repeat domain 48. (677 aa)
FANCLFA complementation group L. (461 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
NUTF2Nuclear transport factor 2. (127 aa)
FAAP24FA core complex associated protein 24. (215 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
KXD1KxDL motif containing 1. (176 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (559 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
SLX4Uncharacterized protein. (929 aa)
FANCEFA complementation group E. (323 aa)
FANCD2Uncharacterized protein. (1458 aa)
FANCGFA complementation group G. (622 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (383 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
RPA3Replication protein A3. (121 aa)
FANCFFA complementation group F. (374 aa)
ENSCSAP00000018444Ubiquitin-like domain-containing protein. (127 aa)
ENSCSAP00000017765Ubiquitin-like domain-containing protein. (155 aa)
ENSCSAP00000017575Ubiquitin-like domain-containing protein. (156 aa)
ENSCSAP00000017472ERCC4 domain-containing protein. (551 aa)
ENSCSAP00000017299Uncharacterized protein. (179 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
UBCUncharacterized protein. (228 aa)
ENSCSAP00000015863Uncharacterized protein. (81 aa)
FANCAFA complementation group A. (1455 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
PROSER1Proline and serine rich 1. (927 aa)
FANCIFA complementation group I. (1199 aa)
ATRIPATR interacting protein. (790 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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