STRINGSTRING
EED EED AKT2 AKT2 PSMC4 PSMC4 PSMC5 PSMC5 PSMB10 PSMB10 PSMD8 PSMD8 WWP2 WWP2 PSMD12 PSMD12 PSMD7 PSMD7 LAMTOR1 LAMTOR1 RNF141 RNF141 PSMA1 PSMA1 CSNK2A2 CSNK2A2 GATAD2A GATAD2A REST REST UBA52 UBA52 KXD1 KXD1 PSMC3 PSMC3 TNRC6B TNRC6B RHEBL1 RHEBL1 MAPK3 MAPK3 CBX7 CBX7 PSMD11 PSMD11 CBX6 CBX6 NPTXR NPTXR MTA2 MTA2 HDAC7 HDAC7 SUZ12 SUZ12 TNKS2 TNKS2 RHEB RHEB CRYGN CRYGN PSMD1 PSMD1 PTEN PTEN EZH2 EZH2 AIRE AIRE TRIM7 TRIM7 TRIM27 TRIM27 MKRN1 MKRN1 TXNDC11 TXNDC11 USP7 USP7 MAF1 MAF1 PSMD10 PSMD10 ENSCSAP00000005494 ENSCSAP00000005494 AKT3 AKT3 MTA1 MTA1 PSMB8 PSMB8 PSMB9 PSMB9 PHC1 PHC1 RING1 RING1 AGO2 AGO2 AKT1 AKT1 MKRN2 MKRN2 PPARG PPARG RCOR1 RCOR1 ATN1 ATN1 CRYBB3 CRYBB3 KIAA1671 KIAA1671 CHD4 CHD4 CSNK2A1 CSNK2A1 PSMF1 PSMF1 MLST8 MLST8 CHD3 CHD3 PSMD13 PSMD13 TP53 TP53 PSMC2 PSMC2 NEDD4 NEDD4 PSMB1 PSMB1 PSMD6 PSMD6 MBD3 MBD3 RRAGB RRAGB STUB1 STUB1 BMI1 BMI1 HDAC3 HDAC3 MECOM MECOM MTA3 MTA3 PHC3 PHC3 RNF2 RNF2 PSMB6 PSMB6 USP13 USP13 EGR1 EGR1 PSMD5 PSMD5 PSMB7 PSMB7 MAPK1 MAPK1 PSMD2 PSMD2 PSME4 PSME4 PREX2 PREX2 PML PML RPS27A RPS27A PSMA3 PSMA3 ATF2 ATF2 SCML2 SCML2 SCML1 SCML1 SNAI2 SNAI2 RBBP7 RBBP7 PSMA4 PSMA4 PSMC6 PSMC6 SNAI1 SNAI1 NR2E1 NR2E1 SALL4 SALL4 PSMA2 PSMA2 PSMA6 PSMA6 PSMD14 PSMD14 HDAC2 HDAC2 FRK FRK PSMA7 PSMA7 PSME2 PSME2 PSMB5 PSMB5 PSME1 PSME1 SLC38A9 SLC38A9 SALL2 SALL2 TNKS TNKS GUF1 GUF1 RRAGD RRAGD BIRC8 BIRC8 ENSCSAP00000013550 ENSCSAP00000013550 NPTX2 NPTX2 PSMA8 PSMA8 LAMTOR4 LAMTOR4 XIAP XIAP HDAC5 HDAC5 OTUD4 OTUD4 PSME3 PSME3 EZH1 EZH1 SNAI3 SNAI3 PSMD3 PSMD3 PSMB3 PSMB3 CBX2 CBX2 CBX8 CBX8 CBX4 CBX4 NPTX1 NPTX1 RPTOR RPTOR PSMD9 PSMD9 LAMTOR2 LAMTOR2 UBC UBC ENSCSAP00000016053 ENSCSAP00000016053 GATAD2B GATAD2B PSMB4 PSMB4 MOV10 MOV10 LAMTOR5 LAMTOR5 PSMA5 PSMA5 SCMH1 SCMH1 RRAGC RRAGC AGO3 AGO3 AGO1 AGO1 AGO4 AGO4 PSMB2 PSMB2 PHC2 PHC2 HDAC1 HDAC1 KDM1A KDM1A OTUD3 OTUD3 MTOR MTOR RERE RERE CHD5 CHD5 ENSCSAP00000017575 ENSCSAP00000017575 ENSCSAP00000017750 ENSCSAP00000017750 ENSCSAP00000017765 ENSCSAP00000017765 JUN JUN LOC103232026 LOC103232026 MBD3L1 MBD3L1 MKRN3 MKRN3 ENSCSAP00000018444 ENSCSAP00000018444 RNF146 RNF146 PSMC1 PSMC1 PSMB11 PSMB11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EEDEmbryonic ectoderm development. (441 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (287 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
RNF141Ring finger protein 141. (230 aa)
PSMA1Proteasome subunit alpha type. (130 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
GATAD2AGATA-type domain-containing protein. (634 aa)
RESTRE1 silencing transcription factor. (1096 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
KXD1KxDL motif containing 1. (176 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (265 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1773 aa)
RHEBL1RHEB like 1. (181 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CBX7Chromobox 7. (250 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
CBX6Chromobox 6. (419 aa)
NPTXRNeuronal pentraxin receptor. (322 aa)
MTA2Metastasis associated 1 family member 2. (668 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (954 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
RHEBRas homolog, mTORC1 binding. (173 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (148 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (958 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
AIREAutoimmune regulator. (548 aa)
TRIM7Tripartite motif containing 7. (514 aa)
TRIM27Tripartite motif containing 27. (513 aa)
MKRN1Makorin ring finger protein 1. (418 aa)
TXNDC11Thioredoxin domain containing 11. (958 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1102 aa)
MAF1Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (258 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSCSAP00000005494ANK_REP_REGION domain-containing protein. (217 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
MTA1Metastasis associated 1. (714 aa)
PSMB8Proteasome subunit beta. (308 aa)
PSMB9Proteasome subunit beta. (219 aa)
PHC1Polyhomeotic homolog 1. (1003 aa)
RING1Ring finger protein 1. (406 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (904 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MKRN2Makorin ring finger protein 2. (416 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
RCOR1REST corepressor 1. (352 aa)
ATN1Atrophin 1. (1183 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
KIAA1671KIAA1671. (1816 aa)
CHD4Uncharacterized protein. (1914 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
CHD3Chromodomain helicase DNA binding protein 3. (1965 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (377 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
NEDD4E3 ubiquitin-protein ligase. (900 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (412 aa)
MBD3Methyl-CpG binding domain protein 3. (291 aa)
RRAGBRas related GTP binding B. (374 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
BMI1RING-type domain-containing protein. (449 aa)
HDAC3Hist_deacetyl domain-containing protein. (266 aa)
MECOMMDS1 and EVI1 complex locus. (1051 aa)
MTA3Metastasis associated 1 family member 3. (594 aa)
PHC3Polyhomeotic homolog 3. (964 aa)
RNF2Ring finger protein 2. (336 aa)
PSMB6Proteasome subunit beta. (239 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
PSMB7Proteasome subunit beta. (277 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSME4Proteasome activator subunit 4. (1843 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1606 aa)
PMLPromyelocytic leukemia. (819 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SCML2Scm polycomb group protein like 2. (635 aa)
SCML1Scm polycomb group protein like 1. (330 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (425 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
FRKTyrosine-protein kinase. (505 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PSME2Proteasome activator subunit 2. (253 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSME1Proteasome activator subunit 1. (238 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
SALL2Spalt like transcription factor 2. (868 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (663 aa)
RRAGDRas related GTP binding D. (400 aa)
BIRC8RING-type domain-containing protein. (236 aa)
ENSCSAP00000013550PROTEASOME_ALPHA_1 domain-containing protein. (218 aa)
NPTX2Neuronal pentraxin 2. (386 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (99 aa)
XIAPRING-type domain-containing protein. (497 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1155 aa)
OTUD4OTU deubiquitinase 4. (1113 aa)
PSME3Proteasome activator subunit 3. (267 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
SNAI3Snail family transcriptional repressor 3. (292 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PSMB3Proteasome subunit beta. (205 aa)
CBX2Chromobox 2. (530 aa)
CBX8Chromobox 8. (385 aa)
CBX4Chromobox 4. (560 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PSMD9PDZ domain-containing protein. (223 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
UBCUncharacterized protein. (228 aa)
ENSCSAP00000016053Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (497 aa)
GATAD2BGATA zinc finger domain containing 2B. (593 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
MOV10Mov10 RISC complex RNA helicase. (1003 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (150 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
SCMH1Scm polycomb group protein homolog 1. (638 aa)
RRAGCRas related GTP binding C. (399 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
PSMB2Proteasome subunit beta. (201 aa)
PHC2Polyhomeotic homolog 2. (859 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (872 aa)
OTUD3OTU deubiquitinase 3. (398 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
REREArginine-glutamic acid dipeptide repeats. (1566 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1954 aa)
ENSCSAP00000017575Ubiquitin-like domain-containing protein. (156 aa)
ENSCSAP00000017750Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
ENSCSAP00000017765Ubiquitin-like domain-containing protein. (155 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
LOC103232026Uncharacterized protein. (124 aa)
MBD3L1Methyl-CpG binding domain protein 3 like 1. (194 aa)
MKRN3Makorin ring finger protein 3. (507 aa)
ENSCSAP00000018444Ubiquitin-like domain-containing protein. (127 aa)
RNF146Ring finger protein 146. (360 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
PSMB11Proteasome subunit beta. (300 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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