STRINGSTRING
PCNA PCNA MAX MAX PSMB11 PSMB11 ENSCSAP00000019055 ENSCSAP00000019055 PSMC1 PSMC1 ENSCSAP00000018444 ENSCSAP00000018444 UBE2C UBE2C ENSCSAP00000017765 ENSCSAP00000017765 ENSCSAP00000017576 ENSCSAP00000017576 ENSCSAP00000017575 ENSCSAP00000017575 CREBZF CREBZF PSMB2 PSMB2 ORC1 ORC1 PSMA5 PSMA5 UBE2S UBE2S PSMB4 PSMB4 POLE POLE UBC UBC POLD1 POLD1 PSMD9 PSMD9 ANAPC5 ANAPC5 ANAPC11 ANAPC11 RFC5 RFC5 PRIM2 PRIM2 MCM8 MCM8 PSMB7 PSMB7 SKP1 SKP1 PSMD2 PSMD2 PSME4 PSME4 RPA1 RPA1 RPS27A RPS27A MNAT1 MNAT1 POLA1 POLA1 PSMA3 PSMA3 CCNA2 CCNA2 AKT2 AKT2 PSMC4 PSMC4 E2F4 E2F4 CDC27 CDC27 PSMC5 PSMC5 PSMB10 PSMB10 POLD3 POLD3 PSMD8 PSMD8 PSMD12 PSMD12 PSMD7 PSMD7 ANAPC15 ANAPC15 LIN37 LIN37 TCERG1L TCERG1L LIN54 LIN54 WEE1 WEE1 CDK4 CDK4 PSMA1 PSMA1 GINS3 GINS3 CCNE1 CCNE1 CDK3 CDK3 PRIM1 PRIM1 SMC3 SMC3 CDK2 CDK2 RBL2 RBL2 UBA52 UBA52 KXD1 KXD1 ORC6 ORC6 PSMC3 PSMC3 RBX1 RBX1 PSMD11 PSMD11 FEN1 FEN1 ATAD5 ATAD5 PSMD1 PSMD1 ENSCSAP00000003124 ENSCSAP00000003124 CUL1 CUL1 GSK3B GSK3B UBE2D1 UBE2D1 CKS2 CKS2 DNA2 DNA2 CDCA5 CDCA5 TM7SF3 TM7SF3 POLA2 POLA2 GMNN GMNN FAM89B FAM89B WEE2 WEE2 MCM5 MCM5 MCM2 MCM2 POLD4 POLD4 ANAPC16 ANAPC16 TM4SF19 TM4SF19 CDKN1B CDKN1B PSMD10 PSMD10 ENSCSAP00000005289 ENSCSAP00000005289 RFC4 RFC4 ENSCSAP00000005494 ENSCSAP00000005494 CCND1 CCND1 AKT3 AKT3 PSMB8 PSMB8 PSMB9 PSMB9 WAPL WAPL AKT1 AKT1 UBE2E1 UBE2E1 MYC MYC CDKN1A CDKN1A FAM89A FAM89A GINS1 GINS1 ENSCSAP00000006740 ENSCSAP00000006740 ENSCSAP00000006748 ENSCSAP00000006748 GINS4 GINS4 POLE2 POLE2 PSMA2 PSMA2 ENSCSAP00000010629 ENSCSAP00000010629 CCNH CCNH MCM4 MCM4 PSMA4 PSMA4 PSMC6 PSMC6 PSMF1 PSMF1 RAD21L1 RAD21L1 ORC2 ORC2 PSMA6 PSMA6 POLD2 POLD2 PSMD14 PSMD14 PSMA7 PSMA7 POLE4 POLE4 CDK7 CDK7 CDC25A CDC25A ESCO2 ESCO2 MCM9 MCM9 PSME2 PSME2 PSMB5 PSMB5 PSME1 PSME1 ORC4 ORC4 MCM6 MCM6 LIN9 LIN9 PTK6 PTK6 ANAPC2 ANAPC2 ANAPC4 ANAPC4 ANAPC1 ANAPC1 RFC1 RFC1 PDS5A PDS5A SKP2 SKP2 ORC3 ORC3 CDC16 CDC16 TFDP1 TFDP1 ENSCSAP00000013550 ENSCSAP00000013550 ESCO1 ESCO1 CABLES1 CABLES1 RCBTB1 RCBTB1 RCBTB2 RCBTB2 RB1 RB1 PSMA8 PSMA8 MCM7 MCM7 CCNA1 CCNA1 RFC3 RFC3 PDS5B PDS5B RFC2 RFC2 STAG2 STAG2 ANAPC10 ANAPC10 PSME3 PSME3 GINS2 GINS2 LIG1 LIG1 CDT1 CDT1 CDC6 CDC6 PSMD3 PSMD3 ANAPC7 ANAPC7 PSMB3 PSMB3 STAG1 STAG1 RAD21 RAD21 FZR1 FZR1 PSMD13 PSMD13 MEIOB MEIOB ORC5 ORC5 CDC45 CDC45 PSMC2 PSMC2 PSMB1 PSMB1 PSMD6 PSMD6 E2F1 E2F1 CDC26 CDC26 POLE3 POLE3 CCNE2 CCNE2 SMC1A SMC1A LIN52 LIN52 CDC25B CDC25B PSMB6 PSMB6 MCM3 MCM3 RPA3 RPA3 E2F5 E2F5 PSMD5 PSMD5 CDC23 CDC23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MAXMYC associated factor X. (103 aa)
PSMB11Proteasome subunit beta. (300 aa)
ENSCSAP00000019055Transcription factor. (409 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
ENSCSAP00000018444Ubiquitin-like domain-containing protein. (127 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
ENSCSAP00000017765Ubiquitin-like domain-containing protein. (155 aa)
ENSCSAP00000017576UBIQUITIN_CONJUGAT_2 domain-containing protein. (175 aa)
ENSCSAP00000017575Ubiquitin-like domain-containing protein. (156 aa)
CREBZFCREB/ATF bZIP transcription factor. (354 aa)
PSMB2Proteasome subunit beta. (201 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa)
UBCUncharacterized protein. (228 aa)
POLD1DNA polymerase. (1086 aa)
PSMD9PDZ domain-containing protein. (223 aa)
ANAPC5Anaphase promoting complex subunit 5. (742 aa)
ANAPC11RING-type domain-containing protein. (84 aa)
RFC5Replication factor C subunit 5. (340 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (840 aa)
PSMB7Proteasome subunit beta. (277 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSME4Proteasome activator subunit 4. (1843 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
POLA1DNA polymerase. (1465 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
E2F4E2F transcription factor 4. (418 aa)
CDC27Cell division cycle 27. (824 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMB10Proteasome subunit beta. (273 aa)
POLD3Uncharacterized protein. (466 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (287 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
ANAPC15Uncharacterized protein. (121 aa)
LIN37Lin-37 DREAM MuvB core complex component. (246 aa)
TCERG1LTranscription elongation regulator 1 like. (340 aa)
LIN54Lin-54 DREAM MuvB core complex component. (749 aa)
WEE1Wee1-like protein kinase. (646 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PSMA1Proteasome subunit alpha type. (130 aa)
GINS3GINS complex subunit 3. (216 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (416 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (314 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
KXD1KxDL motif containing 1. (176 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (265 aa)
RBX1Ring-box 1. (108 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa)
ATAD5ATPase family AAA domain containing 5. (1838 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (958 aa)
ENSCSAP00000003124BTB domain-containing protein. (463 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (162 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
CDCA5Cell division cycle associated 5. (249 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
FAM89BFamily with sequence similarity 89 member B. (189 aa)
WEE2Wee1-like protein kinase. (567 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
MCM2DNA helicase; Belongs to the MCM family. (738 aa)
POLD4Uncharacterized protein. (107 aa)
ANAPC16Anaphase promoting complex subunit 16. (110 aa)
TM4SF19Uncharacterized protein. (209 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSCSAP00000005289DNA primase; Belongs to the eukaryotic-type primase small subunit family. (398 aa)
RFC4Replication factor C subunit 4. (363 aa)
ENSCSAP00000005494ANK_REP_REGION domain-containing protein. (217 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
PSMB8Proteasome subunit beta. (308 aa)
PSMB9Proteasome subunit beta. (219 aa)
WAPLWAPL cohesin release factor. (1190 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
FAM89AFamily with sequence similarity 89 member A. (184 aa)
GINS1GINS complex subunit 1. (285 aa)
ENSCSAP00000006740Uncharacterized protein. (525 aa)
ENSCSAP00000006748Uncharacterized protein. (550 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
ENSCSAP00000010629UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
CCNHCyclin H; Belongs to the cyclin family. (323 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
RAD21L1RAD21 cohesin complex component like 1. (556 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
CDC25ACell division cycle 25A. (523 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (600 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
PSME2Proteasome activator subunit 2. (253 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSME1Proteasome activator subunit 1. (238 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
LIN9Lin-9 DREAM MuvB core complex component. (490 aa)
PTK6Tyrosine-protein kinase. (451 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (786 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
ANAPC1Anaphase promoting complex subunit 1. (1944 aa)
RFC1Replication factor C subunit 1. (985 aa)
PDS5APDS5 cohesin associated factor A. (1293 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
ORC3Origin recognition complex subunit 3. (711 aa)
CDC16Cell division cycle 16. (620 aa)
TFDP1Transcription factor. (410 aa)
ENSCSAP00000013550PROTEASOME_ALPHA_1 domain-containing protein. (218 aa)
ESCO1Establishment of sister chromatid cohesion N-acetyltransferase 1. (840 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (630 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
RB1RB transcriptional corepressor 1. (928 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
RFC3Replication factor C subunit 3. (356 aa)
PDS5BPDS5 cohesin associated factor B. (1448 aa)
RFC2Replication factor C subunit 2. (353 aa)
STAG2Stromal antigen 2. (1268 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
PSME3Proteasome activator subunit 3. (267 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
LIG1DNA ligase. (919 aa)
CDT1Chromatin licensing and DNA replication factor 1. (551 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
ANAPC7Anaphase promoting complex subunit 7. (346 aa)
PSMB3Proteasome subunit beta. (205 aa)
STAG1Stromal antigen 1. (1258 aa)
RAD21RAD21 cohesin complex component. (631 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (377 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
CDC45Cell division cycle 45. (566 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (412 aa)
E2F1E2F transcription factor 1. (437 aa)
CDC26Cell division cycle 26. (85 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (383 aa)
SMC1AStructural maintenance of chromosomes 1A. (1099 aa)
LIN52Lin-52 DREAM MuvB core complex component. (84 aa)
CDC25BCell division cycle 25B. (584 aa)
PSMB6Proteasome subunit beta. (239 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
RPA3Replication protein A3. (121 aa)
E2F5E2F transcription factor 5. (351 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (504 aa)
CDC23Cell division cycle 23. (597 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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