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| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MAX | MYC associated factor X. (103 aa) |
| | PSMB11 | Proteasome subunit beta. (300 aa) |
| | ENSCSAP00000019055 | Transcription factor. (409 aa) |
| | PSMC1 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) |
| | ENSCSAP00000018444 | Ubiquitin-like domain-containing protein. (127 aa) |
| | UBE2C | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | ENSCSAP00000017765 | Ubiquitin-like domain-containing protein. (155 aa) |
| | ENSCSAP00000017576 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (175 aa) |
| | ENSCSAP00000017575 | Ubiquitin-like domain-containing protein. (156 aa) |
| | CREBZF | CREB/ATF bZIP transcription factor. (354 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | UBE2S | Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa) |
| | UBC | Uncharacterized protein. (228 aa) |
| | POLD1 | DNA polymerase. (1086 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (742 aa) |
| | ANAPC11 | RING-type domain-containing protein. (84 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (840 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | PSME4 | Proteasome activator subunit 4. (1843 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa) |
| | POLA1 | DNA polymerase. (1465 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (535 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | E2F4 | E2F transcription factor 4. (418 aa) |
| | CDC27 | Cell division cycle 27. (824 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | POLD3 | Uncharacterized protein. (466 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (287 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (456 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | ANAPC15 | Uncharacterized protein. (121 aa) |
| | LIN37 | Lin-37 DREAM MuvB core complex component. (246 aa) |
| | TCERG1L | Transcription elongation regulator 1 like. (340 aa) |
| | LIN54 | Lin-54 DREAM MuvB core complex component. (749 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | PSMA1 | Proteasome subunit alpha type. (130 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (416 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (314 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1140 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | KXD1 | KxDL motif containing 1. (176 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (265 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1838 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (958 aa) |
| | ENSCSAP00000003124 | BTB domain-containing protein. (463 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | CKS2 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (162 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | CDCA5 | Cell division cycle associated 5. (249 aa) |
| | TM7SF3 | Transmembrane 7 superfamily member 3. (570 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | GMNN | Geminin DNA replication inhibitor. (209 aa) |
| | FAM89B | Family with sequence similarity 89 member B. (189 aa) |
| | WEE2 | Wee1-like protein kinase. (567 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | ANAPC16 | Anaphase promoting complex subunit 16. (110 aa) |
| | TM4SF19 | Uncharacterized protein. (209 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | ENSCSAP00000005289 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (398 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | ENSCSAP00000005494 | ANK_REP_REGION domain-containing protein. (217 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa) |
| | PSMB8 | Proteasome subunit beta. (308 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | WAPL | WAPL cohesin release factor. (1190 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | UBE2E1 | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | FAM89A | Family with sequence similarity 89 member A. (184 aa) |
| | GINS1 | GINS complex subunit 1. (285 aa) |
| | ENSCSAP00000006740 | Uncharacterized protein. (525 aa) |
| | ENSCSAP00000006748 | Uncharacterized protein. (550 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | ENSCSAP00000010629 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa) |
| | CCNH | Cyclin H; Belongs to the cyclin family. (323 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | PSMA4 | Proteasome subunit alpha type. (261 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (271 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (556 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | PSMA6 | Proteasome subunit alpha type. (252 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | PSMA7 | Proteasome subunit alpha type. (248 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa) |
| | CDC25A | Cell division cycle 25A. (523 aa) |
| | ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2. (600 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa) |
| | PSME2 | Proteasome activator subunit 2. (253 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | PSME1 | Proteasome activator subunit 1. (238 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | LIN9 | Lin-9 DREAM MuvB core complex component. (490 aa) |
| | PTK6 | Tyrosine-protein kinase. (451 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (786 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1944 aa) |
| | RFC1 | Replication factor C subunit 1. (985 aa) |
| | PDS5A | PDS5 cohesin associated factor A. (1293 aa) |
| | SKP2 | S-phase kinase associated protein 2. (424 aa) |
| | ORC3 | Origin recognition complex subunit 3. (711 aa) |
| | CDC16 | Cell division cycle 16. (620 aa) |
| | TFDP1 | Transcription factor. (410 aa) |
| | ENSCSAP00000013550 | PROTEASOME_ALPHA_1 domain-containing protein. (218 aa) |
| | ESCO1 | Establishment of sister chromatid cohesion N-acetyltransferase 1. (840 aa) |
| | CABLES1 | Cdk5 and Abl enzyme substrate 1. (630 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | RB1 | RB transcriptional corepressor 1. (928 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | PDS5B | PDS5 cohesin associated factor B. (1448 aa) |
| | RFC2 | Replication factor C subunit 2. (353 aa) |
| | STAG2 | Stromal antigen 2. (1268 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | PSME3 | Proteasome activator subunit 3. (267 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (551 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (346 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | STAG1 | Stromal antigen 1. (1258 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | FZR1 | Fizzy and cell division cycle 20 related 1. (493 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (377 aa) |
| | MEIOB | Meiosis specific with OB-fold. (472 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (412 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (383 aa) |
| | SMC1A | Structural maintenance of chromosomes 1A. (1099 aa) |
| | LIN52 | Lin-52 DREAM MuvB core complex component. (84 aa) |
| | CDC25B | Cell division cycle 25B. (584 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | E2F5 | E2F transcription factor 5. (351 aa) |
| | PSMD5 | Proteasome 26S subunit, non-ATPase 5. (504 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
