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| | ATRIP | ATR interacting protein. (790 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | WRN | WRN RecQ like helicase. (1399 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (429 aa) |
| | CDC25A | Cell division cycle 25A. (523 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa) |
| | PSME2 | Proteasome activator subunit 2. (253 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | PSME1 | Proteasome activator subunit 1. (238 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | BLM | BLM RecQ like helicase. (1423 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (280 aa) |
| | ORC3 | Origin recognition complex subunit 3. (711 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2772 aa) |
| | ENSCSAP00000013550 | PROTEASOME_ALPHA_1 domain-containing protein. (218 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | RFC2 | Replication factor C subunit 2. (353 aa) |
| | BRCA1 | Uncharacterized protein. (663 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | PSME3 | Proteasome activator subunit 3. (267 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component. (2533 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (534 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | CHEK1 | Checkpoint kinase 1. (749 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | UBC | Uncharacterized protein. (228 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | CDC7 | Cell division cycle 7. (576 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa) |
| | ENSCSAP00000016924 | Uncharacterized protein. (199 aa) |
| | CLSPN | Uncharacterized protein. (1132 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | CDK1 | Protein kinase domain-containing protein. (297 aa) |
| | ENSCSAP00000017575 | Ubiquitin-like domain-containing protein. (156 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | LOC103229948 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSCSAP00000017765 | Ubiquitin-like domain-containing protein. (155 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | LOC103222584 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | ENSCSAP00000018444 | Ubiquitin-like domain-containing protein. (127 aa) |
| | PSMC1 | AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa) |
| | HIST1H2BO | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103221972 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC4 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC103221971 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | PSMB11 | Proteasome subunit beta. (300 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | PSMA6 | Proteasome subunit alpha type. (252 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | WDR41 | WD repeat domain 41. (459 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa) |
| | PSMA4 | Proteasome subunit alpha type. (261 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | ENSCSAP00000010913 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (240 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | PSME4 | Proteasome activator subunit 4. (1843 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (840 aa) |
| | PSMD5 | Proteasome 26S subunit, non-ATPase 5. (504 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (874 aa) |
| | CDC25C | Cell division cycle 25C. (474 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (636 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | CCNB3 | Cyclin B3; Belongs to the cyclin family. (1324 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | YWHAZ | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (412 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | ENSCSAP00000007698 | MPN domain-containing protein. (285 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | MEIOB | Meiosis specific with OB-fold. (472 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (377 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (501 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (271 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa) |
| | PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (499 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | CHEK2 | Protein kinase domain-containing protein. (318 aa) |
| | ENSCSAP00000006204 | FHA domain-containing protein. (214 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | PSMB8 | Proteasome subunit beta. (308 aa) |
| | EXO1 | Exonuclease 1. (845 aa) |
| | H2BW2 | H2B histone family member M; Belongs to the histone H2B family. (175 aa) |
| | ENSCSAP00000005636 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | ENSCSAP00000005631 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | ENSCSAP00000005494 | ANK_REP_REGION domain-containing protein. (217 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (718 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) |
| | TM4SF19 | Uncharacterized protein. (209 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1964 aa) |
| | RECQL4 | RecQ like helicase 4. (1210 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | WEE2 | Wee1-like protein kinase. (567 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1000 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (522 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (125 aa) |
| | ENSCSAP00000003124 | BTB domain-containing protein. (463 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (958 aa) |
| | ENSCSAP00000002816 | MPN domain-containing protein. (320 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4834 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1248 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (265 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | KXD1 | KxDL motif containing 1. (176 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | GTSE1 | G2 and S-phase expressed 1. (741 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (314 aa) |
| | PSMA1 | Proteasome subunit alpha type. (130 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (456 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (287 aa) |
| | RNF169 | Ring finger protein 169. (486 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | CNTD2 | CYCLIN domain-containing protein; Belongs to the cyclin family. (123 aa) |
| | ENSCSAP00000000080 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | PSMA7 | Proteasome subunit alpha type. (248 aa) |
