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ATP6V1D ATP6V1D ATP6V1G3 ATP6V1G3 MAPK1 MAPK1 LOC103227720 LOC103227720 ATP6V1E1 ATP6V1E1 GAB4 GAB4 ATP6V1H ATP6V1H ENSCSAP00000010995 ENSCSAP00000010995 ATP6AP1L ATP6AP1L PTPN1 PTPN1 ATP6V1B1 ATP6V1B1 FGFR1 FGFR1 FGFR3 FGFR3 PIK3R1 PIK3R1 GRB10 GRB10 FGF17 FGF17 ATP6V1B2 ATP6V1B2 FGF12 FGF12 FGFR4 FGFR4 INSR INSR FGF10 FGF10 FGF20 FGF20 KLB KLB IRS2 IRS2 ATP6AP1 ATP6AP1 KL KL PIK3C3 PIK3C3 TCIRG1 TCIRG1 ATP6V0A4 ATP6V0A4 ATP6V1G2 ATP6V1G2 KRAS KRAS TRIB2 TRIB2 ATP6V1C2 ATP6V1C2 ATP6V0E2 ATP6V0E2 ATP6V1A ATP6V1A IDE IDE MAPK3 MAPK3 FGF8 FGF8 PIK3R2 PIK3R2 GRB2 GRB2 PDE3B PDE3B FGFR2 FGFR2 FGF5 FGF5 FRS2 FRS2 ATP6V0D1 ATP6V0D1 GAB2 GAB2 AKT2 AKT2 FGF2 FGF2 ERAS ERAS FLT3 FLT3 FGF9 FGF9 PDPK1 PDPK1 GAB1 GAB1 ATP6V0A1 ATP6V0A1 FLT3LG FLT3LG PTPN11 PTPN11 ATP6V0A2 ATP6V0A2 LIM2 LIM2 SHC1 SHC1 THEM4 THEM4 NRAS NRAS NRDC NRDC ATP6V0B ATP6V0B PTPRF PTPRF ENSCSAP00000018032 ENSCSAP00000018032 LOC103221492 LOC103221492 ATP6V1E2 ATP6V1E2 CNST CNST FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 ATP6V0E1 ATP6V0E1 FGF18 FGF18 INS INS CTSD CTSD IFITM10 IFITM10 ATP6V1F ATP6V1F PIK3R4 PIK3R4 ATP6V0C ATP6V0C FGF7 FGF7 FGF16 FGF16 HRAS HRAS FGF6 FGF6 FGF23 FGF23 PIK3CB PIK3CB SPEM2 SPEM2 SPEM1 SPEM1 ATP6V1C1 ATP6V1C1 SOS1 SOS1 FGF1 FGF1 FGF22 FGF22 TRIB3 TRIB3 PIK3CA PIK3CA ATP6V1G1 ATP6V1G1 ATP6V0D2 ATP6V0D2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ATP6V1DUncharacterized protein. (247 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LOC103227720TIR domain-containing protein. (1032 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (227 aa)
GAB4GRB2 associated binding protein family member 4. (638 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
ENSCSAP00000010995V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6AP1LATPase H+ transporting accessory protein 1 like. (299 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
FGFR1Fibroblast growth factor receptor. (830 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (333 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (540 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
FGFR4Fibroblast growth factor receptor. (806 aa)
INSRTyrosine-protein kinase receptor. (1385 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
KLBKlotho beta. (907 aa)
IRS2Insulin receptor substrate 2. (906 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (475 aa)
KLKlotho. (1010 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (542 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
TRIB2Tribbles pseudokinase 2. (284 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
ATP6V0E2Uncharacterized protein. (111 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (978 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PIK3R2Uncharacterized protein. (629 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDE3BPhosphodiesterase. (1117 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
ERASES cell expressed Ras. (233 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (837 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (288 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (173 aa)
SHC1SHC adaptor protein 1. (474 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NRDCNardilysin convertase; Belongs to the peptidase M16 family. (1151 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1926 aa)
ENSCSAP00000018032Uncharacterized protein. (247 aa)
LOC103221492V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
CNSTConsortin, connexin sorting protein. (777 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (412 aa)
IFITM10Interferon induced transmembrane protein 10. (224 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SPEM2SPEM family member 2. (505 aa)
SPEM1Spermatid maturation 1. (309 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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