STRINGSTRING
PRKCA PRKCA CCKBR CCKBR GRB2 GRB2 MAPK3 MAPK3 KRAS KRAS MAPK7 MAPK7 CREB1 CREB1 HRAS HRAS ENSCSAP00000008334 ENSCSAP00000008334 RPS6KA2 RPS6KA2 SOS1 SOS1 HBEGF HBEGF MAPK1 MAPK1 RPS6KA3 RPS6KA3 EGFR EGFR MMP3 MMP3 GAST GAST CSDE1 CSDE1 NRAS NRAS RPS6KA1 RPS6KA1 ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (450 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSCSAP00000008334Uncharacterized protein. (72 aa)
RPS6KA2Ribosomal protein S6 kinase. (730 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
GASTGastrin. (104 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RPS6KA1Ribosomal protein S6 kinase. (735 aa)
ERASES cell expressed Ras. (233 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.