STRINGSTRING
FRS2 FRS2 PTPN11 PTPN11 GAB1 GAB1 PIK3R1 PIK3R1 FYN FYN DOCK3 DOCK3 PLCG1 PLCG1 SRC SRC PIK3CA PIK3CA SOS1 SOS1 FRS3 FRS3 HRAS HRAS NTF3 NTF3 TIAM1 TIAM1 GRIN2B GRIN2B KRAS KRAS NTRK2 NTRK2 CDK5 CDK5 CDK5R1 CDK5R1 GRB2 GRB2 NTF4 NTF4 ERAS ERAS BDNF BDNF NRAS NRAS SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FYNTyrosine-protein kinase. (537 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2065 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
SRCTyrosine-protein kinase. (633 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1466 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1402 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NTRK2Neurotrophic receptor tyrosine kinase 2. (477 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (224 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
ERASES cell expressed Ras. (233 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SHC1SHC adaptor protein 1. (474 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (26%) [HD]