STRINGSTRING
HES1 HES1 EGF EGF WWP2 WWP2 PSENEN PSENEN PBX4 PBX4 NEURL1 NEURL1 EP300 EP300 NOTCH3 NOTCH3 MAMLD1 MAMLD1 DLL4 DLL4 MAML1 MAML1 PLXND1 PLXND1 PBX2 PBX2 JAG2 JAG2 NEURL1B NEURL1B CREBBP CREBBP KAT2B KAT2B WWC1 WWC1 PBX1 PBX1 PTCRA PTCRA SNW1 SNW1 DLL1 DLL1 ADAM10 ADAM10 STAT1 STAT1 APH1B APH1B PSEN1 PSEN1 HEY1 HEY1 PBX3 PBX3 JAG1 JAG1 RPS27A RPS27A DLGAP5 DLGAP5 TACC3 TACC3 NOTCH1 NOTCH1 IKZF1 IKZF1 EGFR EGFR FABP7 FABP7 HEY2 HEY2 PSEN2 PSEN2 RBPJ RBPJ MIB1 MIB1 APH1A APH1A MAML2 MAML2 KAT2A KAT2A NCSTN NCSTN YBX1 YBX1 HEYL HEYL HES5 HES5 MIB2 MIB2 HES4 HES4 ENSCSAP00000017575 ENSCSAP00000017575 ENSCSAP00000017765 ENSCSAP00000017765
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HES1Hes family bHLH transcription factor 1. (280 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
PBX4PBX homeobox 4. (319 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
EP300E1A binding protein p300. (2416 aa)
NOTCH3Notch receptor 3. (1980 aa)
MAMLD1Mastermind like domain containing 1. (810 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
MAML1Mastermind like transcriptional coactivator 1. (790 aa)
PLXND1Plexin D1. (1833 aa)
PBX2PBX homeobox 2. (430 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (555 aa)
CREBBPCREB binding protein. (2417 aa)
KAT2BLysine acetyltransferase 2B. (675 aa)
WWC1WW and C2 domain containing 1. (1159 aa)
PBX1PBX homeobox 1. (301 aa)
PTCRAPre T cell antigen receptor alpha. (204 aa)
SNW1SNW domain containing 1. (536 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
PSEN1Presenilin 1. (467 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
PBX3Homeobox domain-containing protein. (326 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
DLGAP5DLG associated protein 5. (699 aa)
TACC3Transforming acidic coiled-coil containing protein 3. (839 aa)
NOTCH1Notch receptor 1. (2555 aa)
IKZF1IKAROS family zinc finger 1. (519 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FABP7Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (357 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
MAML2Mastermind like transcriptional coactivator 2. (923 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
NCSTNNicastrin. (709 aa)
YBX1Y-box binding protein 1. (255 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (955 aa)
HES4Hes family bHLH transcription factor 4. (221 aa)
ENSCSAP00000017575Ubiquitin-like domain-containing protein. (156 aa)
ENSCSAP00000017765Ubiquitin-like domain-containing protein. (155 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.