STRINGSTRING
PSEN1 PSEN1 PSENEN PSENEN DLL4 DLL4 NOTCH4 NOTCH4 ADAM10 ADAM10 YWHAZ YWHAZ APH1B APH1B CRB1 CRB1 JAG1 JAG1 PSEN2 PSEN2 APH1A APH1A NCSTN NCSTN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSEN1Presenilin 1. (467 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
NOTCH4Notch receptor 4. (1994 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
CRB1Crumbs cell polarity complex component 1. (1335 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
NCSTNNicastrin. (709 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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