STRINGSTRING
ERAS ERAS LYN LYN RAPGEF1 RAPGEF1 IRS2 IRS2 EPO EPO NRAS NRAS SHC1 SHC1 GRB2 GRB2 EPOR EPOR KRAS KRAS JAK2 JAK2 VAV1 VAV1 HRAS HRAS SOS1 SOS1 CRKL CRKL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERASES cell expressed Ras. (233 aa)
LYNTyrosine-protein kinase. (512 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1264 aa)
IRS2Insulin receptor substrate 2. (906 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SHC1SHC adaptor protein 1. (474 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (511 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
VAV1Vav guanine nucleotide exchange factor 1. (719 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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