(12 nodes) TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling network (Chlorocebus sabaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (686 aa)
	IRF7	Interferon regulatory factor 7. (506 aa)
	LOC103227720	TIR domain-containing protein. (1032 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	ENSCSAP00000000080	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	ENSCSAP00000017575	Ubiquitin-like domain-containing protein. (156 aa)
	UBE2NL	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	ENSCSAP00000017765	Ubiquitin-like domain-containing protein. (155 aa)

Your Current Organism:

Chlorocebus sabaeus

NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSAP00000000080	ENSCSAP00000017575	ENSCSAP00000000080	ENSCSAP00000017575	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.772
ENSCSAP00000000080	ENSCSAP00000017765	ENSCSAP00000000080	ENSCSAP00000017765	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.772
ENSCSAP00000000080	IRAK1	ENSCSAP00000000080	ENSCSAP00000003089	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Interleukin 1 receptor associated kinase 1.	0.603
ENSCSAP00000000080	IRAK4	ENSCSAP00000000080	ENSCSAP00000003071	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Interleukin 1 receptor associated kinase 4.	0.668
ENSCSAP00000000080	RPS27A	ENSCSAP00000000080	ENSCSAP00000010276	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.772
ENSCSAP00000000080	TRAF6	ENSCSAP00000000080	ENSCSAP00000001791	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.943
ENSCSAP00000017575	ENSCSAP00000000080	ENSCSAP00000017575	ENSCSAP00000000080	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.772
ENSCSAP00000017575	IRAK1	ENSCSAP00000017575	ENSCSAP00000003089	Ubiquitin-like domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.404
ENSCSAP00000017575	MYD88	ENSCSAP00000017575	ENSCSAP00000010525	Ubiquitin-like domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.411
ENSCSAP00000017575	TRAF6	ENSCSAP00000017575	ENSCSAP00000001791	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.848
ENSCSAP00000017575	UBE2NL	ENSCSAP00000017575	ENSCSAP00000017712	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.772
ENSCSAP00000017765	ENSCSAP00000000080	ENSCSAP00000017765	ENSCSAP00000000080	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.772
ENSCSAP00000017765	IRAK1	ENSCSAP00000017765	ENSCSAP00000003089	Ubiquitin-like domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.404
ENSCSAP00000017765	MYD88	ENSCSAP00000017765	ENSCSAP00000010525	Ubiquitin-like domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.411
ENSCSAP00000017765	TRAF6	ENSCSAP00000017765	ENSCSAP00000001791	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.848
ENSCSAP00000017765	UBE2NL	ENSCSAP00000017765	ENSCSAP00000017712	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.772
IRAK1	ENSCSAP00000000080	ENSCSAP00000003089	ENSCSAP00000000080	Interleukin 1 receptor associated kinase 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.603
IRAK1	ENSCSAP00000017575	ENSCSAP00000003089	ENSCSAP00000017575	Interleukin 1 receptor associated kinase 1.	Ubiquitin-like domain-containing protein.	0.404
IRAK1	ENSCSAP00000017765	ENSCSAP00000003089	ENSCSAP00000017765	Interleukin 1 receptor associated kinase 1.	Ubiquitin-like domain-containing protein.	0.404
IRAK1	IRAK4	ENSCSAP00000003089	ENSCSAP00000003071	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor associated kinase 4.	0.996

page 1 of 5

Server load: low (16%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About