node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH3A1 | ALDH3B1 | ENSCSAP00000004090 | ENSCSAP00000005010 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.902 |
ALDH3B1 | ALDH3A1 | ENSCSAP00000005010 | ENSCSAP00000004090 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.902 |
APAF1 | CASP3 | ENSCSAP00000014527 | ENSCSAP00000015040 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 3; Belongs to the peptidase C14A family. | 0.994 |
CASP3 | APAF1 | ENSCSAP00000015040 | ENSCSAP00000014527 | Caspase 3; Belongs to the peptidase C14A family. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.994 |
CASP3 | CCNB2 | ENSCSAP00000015040 | ENSCSAP00000008212 | Caspase 3; Belongs to the peptidase C14A family. | Cyclin B2; Belongs to the cyclin family. | 0.489 |
CASP3 | PPARG | ENSCSAP00000015040 | ENSCSAP00000006082 | Caspase 3; Belongs to the peptidase C14A family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.406 |
CCNB2 | CASP3 | ENSCSAP00000008212 | ENSCSAP00000015040 | Cyclin B2; Belongs to the cyclin family. | Caspase 3; Belongs to the peptidase C14A family. | 0.489 |
CCNB2 | PCNA | ENSCSAP00000008212 | ENSCSAP00000009557 | Cyclin B2; Belongs to the cyclin family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.441 |
CD36 | PPARG | ENSCSAP00000008090 | ENSCSAP00000006082 | CD36 molecule; Belongs to the CD36 family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.696 |
EGR1 | PPARG | ENSCSAP00000009282 | ENSCSAP00000006082 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.614 |
PCNA | CCNB2 | ENSCSAP00000009557 | ENSCSAP00000008212 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Cyclin B2; Belongs to the cyclin family. | 0.441 |
PPARG | CASP3 | ENSCSAP00000006082 | ENSCSAP00000015040 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Caspase 3; Belongs to the peptidase C14A family. | 0.406 |
PPARG | CD36 | ENSCSAP00000006082 | ENSCSAP00000008090 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | CD36 molecule; Belongs to the CD36 family. | 0.696 |
PPARG | EGR1 | ENSCSAP00000006082 | ENSCSAP00000009282 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.614 |