54 items (Chlorocebus sabaeus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SERINC3	Serine incorporator 3. (474 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	CPSF6	Cleavage and polyadenylation specific factor 6. (588 aa)
	TRIM21	Tripartite motif containing 21. (475 aa)
	TRIM5	Uncharacterized protein. (515 aa)
	EME1	Essential meiotic structure-specific endonuclease 1. (571 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
	SLFN11	Schlafen family member 11. (891 aa)
	SUN2	Sad1 and UNC84 domain containing 2. (720 aa)
	PLK1	Serine/threonine-protein kinase PLK. (569 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	NUP153	Nucleoporin 153. (1473 aa)
	APOB	Apolipoprotein B. (4555 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (738 aa)
	IFNA2	Interferon alpha 2. (190 aa)
	SLX4	Uncharacterized protein. (929 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa)
	CD4	CD4 molecule. (560 aa)
	ELOB	Ubiquitin-like domain-containing protein. (118 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	IFITM3	Uncharacterized protein. (104 aa)
	MAVS	Mitochondrial antiviral signaling protein. (540 aa)
	SIGLEC1	Sialic acid binding Ig like lectin 1. (1702 aa)
	PQBP1	Polyglutamine binding protein 1. (265 aa)
	ELOC	Elongin C; Belongs to the SKP1 family. (112 aa)
	CGAS	Cyclic GMP-AMP synthase. (526 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1507 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	NCK2	Cytoplasmic protein. (382 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (759 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (900 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
	CASP1	Caspase 1; Belongs to the peptidase C14A family. (462 aa)
	ENSCSAP00000014978	Uncharacterized protein; Belongs to the peptidase C14A family. (392 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (780 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	IRF3	Interferon regulatory factor 3. (422 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	IFI16	Interferon gamma inducible protein 16. (728 aa)
	H2AX	Histone H2A; Belongs to the histone H2A family. (143 aa)
	CDK1	Protein kinase domain-containing protein. (297 aa)
	TLR2	Toll-like receptor. (784 aa)
	LOC103222584	UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
	CCR5	C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
	ENSCSAP00000018734	Ubiquitin-like domain-containing protein. (118 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1040 aa)
	TLR6	Toll-like receptor. (796 aa)

Your Current Organism:

Chlorocebus sabaeus

NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	CASP1	ENSCSAP00000015597	ENSCSAP00000014966	Absent in melanoma 2.	Caspase 1; Belongs to the peptidase C14A family.	0.934
AIM2	CGAS	ENSCSAP00000015597	ENSCSAP00000010160	Absent in melanoma 2.	Cyclic GMP-AMP synthase.	0.803
AIM2	ENSCSAP00000014978	ENSCSAP00000015597	ENSCSAP00000014978	Absent in melanoma 2.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.913
AIM2	IFI16	ENSCSAP00000015597	ENSCSAP00000015600	Absent in melanoma 2.	Interferon gamma inducible protein 16.	0.961
AIM2	IL18	ENSCSAP00000015597	ENSCSAP00000015225	Absent in melanoma 2.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.702
AIM2	IL1B	ENSCSAP00000015597	ENSCSAP00000012813	Absent in melanoma 2.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.688
AIM2	IRF3	ENSCSAP00000015597	ENSCSAP00000015566	Absent in melanoma 2.	Interferon regulatory factor 3.	0.532
AIM2	MAVS	ENSCSAP00000015597	ENSCSAP00000009126	Absent in melanoma 2.	Mitochondrial antiviral signaling protein.	0.455
AIM2	MYD88	ENSCSAP00000015597	ENSCSAP00000010525	Absent in melanoma 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.417
AIM2	TLR2	ENSCSAP00000015597	ENSCSAP00000017617	Absent in melanoma 2.	Toll-like receptor.	0.457
AIM2	TLR3	ENSCSAP00000015597	ENSCSAP00000015097	Absent in melanoma 2.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.458
AIM2	TLR7	ENSCSAP00000015597	ENSCSAP00000019028	Absent in melanoma 2.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.499
AIM2	TLR8	ENSCSAP00000015597	ENSCSAP00000019029	Absent in melanoma 2.	Toll like receptor 8; Belongs to the Toll-like receptor family.	0.609
APOB	CD4	ENSCSAP00000004392	ENSCSAP00000006497	Apolipoprotein B.	CD4 molecule.	0.677
APOB	SAMHD1	ENSCSAP00000004392	ENSCSAP00000006187	Apolipoprotein B.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.547
APOB	TLR2	ENSCSAP00000004392	ENSCSAP00000017617	Apolipoprotein B.	Toll-like receptor.	0.422
APOB	TLR3	ENSCSAP00000004392	ENSCSAP00000015097	Apolipoprotein B.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.461
APOB	TLR6	ENSCSAP00000004392	ENSCSAP00000019187	Apolipoprotein B.	Toll-like receptor.	0.402
APOB	TRIM5	ENSCSAP00000004392	ENSCSAP00000000639	Apolipoprotein B.	Uncharacterized protein.	0.655
ATG5	CASP1	ENSCSAP00000010869	ENSCSAP00000014966	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 1; Belongs to the peptidase C14A family.	0.498

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