STRINGSTRING
KLRG1 KLRG1 IL2 IL2 IFNG IFNG TBK1 TBK1 CXCL10 CXCL10 H3F3B H3F3B AMBRA1 AMBRA1 GSK3B GSK3B TYK2 TYK2 TFAM TFAM NOS2 NOS2 SIRT1 SIRT1 HMOX1 HMOX1 IFNA2 IFNA2 ATG7 ATG7 TRAF3 TRAF3 CD4 CD4 LAG3 LAG3 LOC103232061 LOC103232061 MAVS MAVS TLR4 TLR4 ENSCSAP00000009816 ENSCSAP00000009816 IL6 IL6 ATG5 ATG5 GZMB GZMB IL1B IL1B MCL1 MCL1 BCL2 BCL2 MBP MBP APAF1 APAF1 BRCA1 BRCA1 BECN1 BECN1 APOE APOE CASP3 CASP3 TLR3 TLR3 IRF3 IRF3 CD160 CD160 PRKACB PRKACB CASP9 CASP9 TLR2 TLR2 LOC103247786 LOC103247786 LOC103232262 LOC103232262 ENSCSAP00000017986 ENSCSAP00000017986 PRKACG PRKACG LOC103215048 LOC103215048 H3C11 H3C11 LOC103221619 LOC103221619 ENSCSAP00000018835 ENSCSAP00000018835 LOC103230365 LOC103230365 TLR7 TLR7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLRG1Killer cell lectin like receptor G1. (195 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
TBK1TANK binding kinase 1. (729 aa)
CXCL10C-X-C motif chemokine. (98 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1208 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
TYK2Tyrosine-protein kinase. (1184 aa)
TFAMTranscription factor A, mitochondrial. (248 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
SIRT1Sirtuin 1. (743 aa)
HMOX1Heme oxygenase 1. (288 aa)
IFNA2Interferon alpha 2. (190 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CD4CD4 molecule. (560 aa)
LAG3Lymphocyte activating 3. (539 aa)
LOC103232061Histone domain-containing protein. (136 aa)
MAVSMitochondrial antiviral signaling protein. (540 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
ENSCSAP00000009816Histone H3; Belongs to the histone H3 family. (136 aa)
IL6Interleukin 6. (212 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (290 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MBPMyelin basic protein. (330 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
BRCA1Uncharacterized protein. (663 aa)
BECN1Beclin 1. (450 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
IRF3Interferon regulatory factor 3. (422 aa)
CD160CD160 molecule. (181 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (415 aa)
TLR2Toll-like receptor. (784 aa)
LOC103247786Histone H3; Belongs to the histone H3 family. (136 aa)
LOC103232262Histone H3; Belongs to the histone H3 family. (136 aa)
ENSCSAP00000017986Histone domain-containing protein. (136 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
LOC103215048Histone domain-containing protein. (136 aa)
H3C11Histone H3; Belongs to the histone H3 family. (136 aa)
LOC103221619Histone domain-containing protein. (136 aa)
ENSCSAP00000018835Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC103230365Histone H3; Belongs to the histone H3 family. (136 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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