STRINGSTRING
VPS51 VPS51 BCL2 BCL2 MCL1 MCL1 FURIN FURIN CTSB CTSB CCK CCK STX16 STX16 SULF2 SULF2 VPS54 VPS54 SNX2 SNX2 IL6 IL6 SULF1 SULF1 BAG2 BAG2 EDEM3 EDEM3 DERL2 DERL2 UFD1 UFD1 SEL1L SEL1L DERL3 DERL3 EEF2 EEF2 DERL1 DERL1 XBP1 XBP1 BAG1 BAG1 CTSD CTSD UBR1 UBR1 CANX CANX SNX4 SNX4 ERGIC2 ERGIC2 BMF BMF CALR CALR CALR3 CALR3 SLC35C1 SLC35C1 VPS35 VPS35 PRKACB PRKACB CASP9 CASP9 RER1 RER1 ENSCSAP00000017587 ENSCSAP00000017587 FUT9 FUT9 PRKACG PRKACG TXN TXN HRK HRK ENSCSAP00000018809 ENSCSAP00000018809 ENSCSAP00000018835 ENSCSAP00000018835 SEC22B SEC22B NPLOC4 NPLOC4 ATF6 ATF6 BAX BAX CASP3 CASP3 ENSCSAP00000014978 ENSCSAP00000014978 CASP1 CASP1 RAB5C RAB5C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VPS51VPS51 subunit of GARP complex. (806 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
CCKCholecystokinin. (114 aa)
STX16Syntaxin 16; Belongs to the syntaxin family. (304 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (950 aa)
VPS54VPS54 subunit of GARP complex. (965 aa)
SNX2Sorting nexin 2. (519 aa)
IL6Interleukin 6. (212 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
BAG2BCL2 associated athanogene 2. (211 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (948 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (265 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (235 aa)
EEF2Eukaryotic translation elongation factor 2. (858 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
XBP1X-box binding protein 1. (261 aa)
BAG1BCL2 associated athanogene 1. (339 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (412 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1486 aa)
CANXCalnexin. (610 aa)
SNX4Sorting nexin 4. (450 aa)
ERGIC2ERGIC and golgi 2. (377 aa)
BMFBcl2 modifying factor. (184 aa)
CALRCalreticulin. (417 aa)
CALR3Calreticulin. (367 aa)
SLC35C1Solute carrier family 35 member C1. (351 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (415 aa)
RER1Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (196 aa)
ENSCSAP00000017587Thioredoxin; Belongs to the thioredoxin family. (105 aa)
FUT9Fucosyltransferase 9. (359 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
HRKActivator of apoptosis harakiri; Promotes apoptosis. (91 aa)
ENSCSAP00000018809Thioredoxin; Belongs to the thioredoxin family. (102 aa)
ENSCSAP00000018835Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
NPLOC4NPL4 homolog, ubiquitin recognition factor. (608 aa)
ATF6Activating transcription factor 6. (669 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
ENSCSAP00000014978Uncharacterized protein; Belongs to the peptidase C14A family. (392 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (462 aa)
RAB5CRAB5C, member RAS oncogene family. (255 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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