STRINGSTRING
TSG101 TSG101 IST1 IST1 WWP2 WWP2 ENSCSAP00000018918 ENSCSAP00000018918 VPS4B VPS4B POLI POLI ARRDC1 ARRDC1 IMPDH2 IMPDH2 WWP1 WWP1 ITCH ITCH NEDD4 NEDD4 SPAST SPAST IFITM3 IFITM3 ANXA6 ANXA6 UBAP1 UBAP1 PDCD6IP PDCD6IP TOM1 TOM1 THBS1 THBS1 CEP55 CEP55 MVB12A MVB12A ATP5F1B ATP5F1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSG101Tumor susceptibility 101. (390 aa)
IST1IST1 factor associated with ESCRT-III. (364 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
ENSCSAP00000018918Uncharacterized protein. (133 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
POLIDNA polymerase iota. (672 aa)
ARRDC1Arrestin domain containing 1. (427 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
WWP1WW domain containing E3 ubiquitin protein ligase 1. (684 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
NEDD4E3 ubiquitin-protein ligase. (900 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (614 aa)
IFITM3Uncharacterized protein. (104 aa)
ANXA6Annexin. (676 aa)
UBAP1Ubiquitin associated protein 1. (502 aa)
PDCD6IPBRO1 domain-containing protein. (868 aa)
TOM1Target of myb1 membrane trafficking protein; Belongs to the TOM1 family. (510 aa)
THBS1Thrombospondin 1. (1170 aa)
CEP55Centrosomal protein 55. (465 aa)
MVB12AMultivesicular body subunit 12A. (273 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.