STRINGSTRING
PLIN2 PLIN2 IST1 IST1 SUMO2 SUMO2 ATG2A ATG2A SUMO3 SUMO3 VPS13A VPS13A ACSL3 ACSL3 SPAST SPAST VPS13C VPS13C VPS13B VPS13B ENSCSAP00000009809 ENSCSAP00000009809 VAPB VAPB CHMP6 CHMP6 HGS HGS PRCC PRCC VPS13D VPS13D ENSCSAP00000017749 ENSCSAP00000017749 SUMO1 SUMO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLIN2Perilipin; Belongs to the perilipin family. (437 aa)
IST1IST1 factor associated with ESCRT-III. (364 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
ATG2AAutophagy related 2A. (1932 aa)
SUMO3Small ubiquitin-related modifier. (110 aa)
VPS13AVacuolar protein sorting 13 homolog A. (3067 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (614 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3754 aa)
VPS13BVacuolar protein sorting 13 homolog B. (3997 aa)
ENSCSAP00000009809Uncharacterized protein. (268 aa)
VAPBVAMP associated protein B and C. (243 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
PRCCProline rich mitotic checkpoint control factor. (491 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4387 aa)
ENSCSAP00000017749Small ubiquitin-related modifier. (103 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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