STRINGSTRING
RAB7A RAB7A RAB5A RAB5A DDX58 DDX58 ATG7 ATG7 ENSCSAP00000006322 ENSCSAP00000006322 SIGMAR1 SIGMAR1 GLIPR2 GLIPR2 DEPTOR DEPTOR STX17 STX17 TFEB TFEB GABARAP GABARAP MAP1LC3A MAP1LC3A PLP2 PLP2 MAVS MAVS STING1 STING1 SNAP29 SNAP29 VPS16 VPS16 HSPA5 HSPA5 IL6 IL6 TAX1BP1 TAX1BP1 ATG14 ATG14 RB1CC1 RB1CC1 ATG5 ATG5 ATG12 ATG12 VAMP8 VAMP8 IL1B IL1B RICTOR RICTOR SKP2 SKP2 LAMP1 LAMP1 WIPI2 WIPI2 PIK3C3 PIK3C3 BCL2 BCL2 NBR1 NBR1 BECN1 BECN1 IRF8 IRF8 VPS11 VPS11 CALCOCO2 CALCOCO2 VPS33A VPS33A ULK1 ULK1 MTOR MTOR IFNB1 IFNB1 TOMM20 TOMM20 RAB9A RAB9A SQSTM1 SQSTM1 APOB APOB VPS18 VPS18 ATG16L1 ATG16L1 TUFM TUFM TOMM70 TOMM70 SREBF2 SREBF2 AMBRA1 AMBRA1 LAMTOR1 LAMTOR1 UVRAG UVRAG ITGB3 ITGB3 VPS39 VPS39
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB7ARAB7A, member RAS oncogene family. (207 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
DDX58DExD/H-box helicase 58. (925 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
ENSCSAP00000006322Uncharacterized protein. (90 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (154 aa)
DEPTORDEP domain containing MTOR interacting protein. (409 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (302 aa)
TFEBTranscription factor EB. (475 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
PLP2Proteolipid protein 2. (152 aa)
MAVSMitochondrial antiviral signaling protein. (540 aa)
STING1Transmembrane protein 173. (379 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
IL6Interleukin 6. (212 aa)
TAX1BP1Tax1 binding protein 1. (771 aa)
ATG14Autophagy related 14. (492 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1679 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
LAMP1Lysosomal associated membrane protein 1. (416 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (443 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
NBR1NBR1 autophagy cargo receptor. (967 aa)
BECN1Beclin 1. (450 aa)
IRF8Interferon regulatory factor 8. (426 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (446 aa)
VPS33AUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (534 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1070 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IFNB1Interferon beta 1. (187 aa)
TOMM20Uncharacterized protein. (145 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
SQSTM1Sequestosome 1. (440 aa)
APOBApolipoprotein B. (4555 aa)
VPS18VPS18 core subunit of CORVET and HOPS complexes. (973 aa)
ATG16L1Autophagy related 16 like 1. (588 aa)
TUFMElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (455 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (608 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1144 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1208 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
UVRAGUV radiation resistance associated. (699 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
VPS39VPS39 subunit of HOPS complex. (751 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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