STRINGSTRING
FGF2 FGF2 AKT2 AKT2 EGF EGF PRKCA PRKCA EIF4E EIF4E FGFR2 FGFR2 GRB2 GRB2 PDGFRA PDGFRA KDR KDR ERBB3 ERBB3 PIK3R2 PIK3R2 RPS6KB1 RPS6KB1 MAPK3 MAPK3 PDGFB PDGFB EIF4E2 EIF4E2 PRKCB PRKCB NF1 NF1 PTEN PTEN GSK3B GSK3B BAD BAD SHC3 SHC3 KRAS KRAS BRAF BRAF JAK2 JAK2 EIF4E1B EIF4E1B AKT3 AKT3 RPS6 RPS6 RAF1 RAF1 AKT1 AKT1 SHC4 SHC4 MAP2K2 MAP2K2 MET MET HRAS HRAS PIK3CB PIK3CB PDGFRB PDGFRB HGF HGF VEGFA VEGFA SOS1 SOS1 BCL2L1 BCL2L1 NRG2 NRG2 PIK3CA PIK3CA SHC2 SHC2 MAP2K1 MAP2K1 ARAF ARAF MAPK1 MAPK1 SRC SRC IL6 IL6 PLCG1 PLCG1 TGFA TGFA FOXO3 FOXO3 SOS2 SOS2 EIF4EBP1 EIF4EBP1 FGFR3 FGFR3 NRG1 NRG1 PIK3R1 PIK3R1 EGFR EGFR IGF1R IGF1R GAS6 GAS6 PDGFA PDGFA BCL2 BCL2 AXL AXL GAB1 GAB1 PLCG2 PLCG2 IGF1 IGF1 PDGFC PDGFC STAT3 STAT3 PDGFD PDGFD BAX BAX ERBB2 ERBB2 IL6R IL6R PRKCG PRKCG NRAS NRAS JAK1 JAK1 PIK3R3 PIK3R3 MTOR MTOR PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1342 aa)
PIK3R2Uncharacterized protein. (629 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
NF1Neurofibromin 1. (2849 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SHC3SHC adaptor protein 3. (598 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (266 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
BCL2L1BCL2 like 1. (233 aa)
NRG2Neuregulin 2. (850 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SHC2Uncharacterized protein. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SRCTyrosine-protein kinase. (633 aa)
IL6Interleukin 6. (212 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
TGFATransforming growth factor alpha. (158 aa)
FOXO3Forkhead box O3. (672 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
FGFR3Fibroblast growth factor receptor. (806 aa)
NRG1Neuregulin 1. (467 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
GAS6Growth arrest specific 6. (542 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IGF1Insulin like growth factor 1. (159 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PDGFDPlatelet derived growth factor D. (332 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
IL6RInterleukin 6 receptor. (443 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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