STRINGSTRING
AKT2 AKT2 MDM2 MDM2 GSTO2 GSTO2 GSTO1 GSTO1 PIK3R2 PIK3R2 ABCC2 ABCC2 MAPK3 MAPK3 BAD BAD MGST1 MGST1 GSTP1 GSTP1 AKT3 AKT3 FADD FADD BAK1 BAK1 ENSCSAP00000005944 ENSCSAP00000005944 AKT1 AKT1 TOP2B TOP2B CDKN1A CDKN1A MGST3 MGST3 ATP7A ATP7A CASP8 CASP8 XPA XPA LOC103223040 LOC103223040 ENSCSAP00000007185 ENSCSAP00000007185 PIK3CB PIK3CB TP53 TP53 FASLG FASLG POLH POLH SLC31A1 SLC31A1 BCL2L1 BCL2L1 PIK3CA PIK3CA GSTA1 GSTA1 GSTA2 GSTA2 ENSCSAP00000009288 ENSCSAP00000009288 GSTA4 GSTA4 MSH2 MSH2 MSH6 MSH6 MAPK1 MAPK1 MLH1 MLH1 MSH3 MSH3 REV3L REV3L PIK3R1 PIK3R1 MAP3K5 MAP3K5 ATP7B ATP7B BCL2 BCL2 PDPK1 PDPK1 XIAP XIAP MGST2 MGST2 APAF1 APAF1 BRCA1 BRCA1 ERCC1 ERCC1 CASP3 CASP3 BBC3 BBC3 ATM ATM TOP2A TOP2A BAX BAX ERBB2 ERBB2 BIRC5 BIRC5 GSTM3 GSTM3 GSTM5 GSTM5 GSTM4 GSTM4 PIK3R3 PIK3R3 PIK3CD PIK3CD ENSCSAP00000018835 ENSCSAP00000018835
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (215 aa)
GSTO1Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
PIK3R2Uncharacterized protein. (629 aa)
ABCC2ATP binding cassette subfamily C member 2. (1551 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
GSTP1Glutathione S-transferase pi 1. (383 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
FADDDED domain-containing protein. (189 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSCSAP00000005944Uncharacterized protein. (173 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1621 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (496 aa)
XPAXPA, DNA damage recognition and repair factor. (226 aa)
LOC103223040Uncharacterized protein. (240 aa)
ENSCSAP00000007185Uncharacterized protein; Belongs to the GST superfamily. (195 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (282 aa)
POLHDNA polymerase eta. (712 aa)
SLC31A1Solute carrier family 31 member 1. (190 aa)
BCL2L1BCL2 like 1. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GSTA1Glutathione S-transferase alpha 1. (222 aa)
GSTA2Glutathione S-transferase alpha 2; Belongs to the GST superfamily. (222 aa)
ENSCSAP00000009288Uncharacterized protein; Belongs to the GST superfamily. (224 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MLH1MutL homolog 1. (756 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1125 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3128 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1219 aa)
ATP7BATPase copper transporting beta. (1465 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
XIAPRING-type domain-containing protein. (497 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
BRCA1Uncharacterized protein. (663 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
BBC3Uncharacterized protein. (199 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
BIRC5Uncharacterized protein. (142 aa)
GSTM3Glutathione S-transferase. (225 aa)
GSTM5Glutathione S-transferase mu 5. (218 aa)
GSTM4Glutathione S-transferase mu 4. (218 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ENSCSAP00000018835Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.