STRINGSTRING
BCAR1 BCAR1 AKT2 AKT2 PAK1 PAK1 NFKBIB NFKBIB ARRB1 ARRB1 NFKB1 NFKB1 RAP1B RAP1B CXCL13 CXCL13 CXCL11 CXCL11 CXCL10 CXCL10 CXCL9 CXCL9 GRB2 GRB2 CXCL5 CXCL5 GRK5 GRK5 CXCL2 CXCL2 CXCL3 CXCL3 ENSCSAP00000001089 ENSCSAP00000001089 PPBP PPBP PF4 PF4 ENSCSAP00000001094 ENSCSAP00000001094 CXCL1 CXCL1 PF4V1 PF4V1 CXCL6 CXCL6 CXCL8 CXCL8 CCL17 CCL17 CX3CL1 CX3CL1 CCL22 CCL22 STAT2 STAT2 ADCY7 ADCY7 PIK3R2 PIK3R2 JAK3 JAK3 CHUK CHUK CCL3 CCL3 ENSCSAP00000002431 ENSCSAP00000002431 MAPK3 MAPK3 ENSCSAP00000002492 ENSCSAP00000002492 CCL18 CCL18 CCL15 CCL15 CCL14 CCL14 CCL16 CCL16 CCL5 CCL5 ADCY6 ADCY6 CCL8 CCL8 CCL13 CCL13 CCL11 CCL11 CCL2 CCL2 PRKCB PRKCB GNG3 GNG3 IKBKG IKBKG PLCB3 PLCB3 CCL20 CCL20 GSK3B GSK3B BAD BAD RASGRP2 RASGRP2 ROCK2 ROCK2 SHC3 SHC3 PLCB2 PLCB2 RAC2 RAC2 ADCY5 ADCY5 GNAQ GNAQ KRAS KRAS RELA RELA BRAF BRAF GRK2 GRK2 ADCY3 ADCY3 GRK6 GRK6 JAK2 JAK2 VAV1 VAV1 AKT3 AKT3 TIAM1 TIAM1 RAF1 RAF1 ADCY9 ADCY9 AKT1 AKT1 ADCY8 ADCY8 DOCK2 DOCK2 CCL27 CCL27 GRK3 GRK3 CCL19 CCL19 CCL21 CCL21 GNB3 GNB3 PIK3R5 PIK3R5 PIK3R6 PIK3R6 SHC4 SHC4 ITK ITK CXCL12 CXCL12 HRAS HRAS LOC103230637 LOC103230637 LOC103230639 LOC103230639 PIK3CB PIK3CB GRK7 GRK7 CXCR3 CXCR3 GNB5 GNB5 PARD3 PARD3 PIK3CG PIK3CG GNG7 GNG7 GNAI1 GNAI1 CCR6 CCR6 STAT1 STAT1 GNG10 GNG10 SOS1 SOS1 HCK HCK GNG11 GNG11 PIK3CA PIK3CA GNB4 GNB4 PRKCD PRKCD SHC2 SHC2 CXCL16 CXCL16 MAP2K1 MAP2K1 CRKL CRKL WAS WAS CXCL14 CXCL14 PLCB1 PLCB1 PLCB4 PLCB4 MAPK1 MAPK1 SRC SRC PLCG1 PLCG1 CRK CRK GNAI2 GNAI2 LYN LYN PREX1 PREX1 IKBKB IKBKB ELMO1 ELMO1 RHOA RHOA GNG2 GNG2 FOXO3 FOXO3 SOS2 SOS2 NFKBIA NFKBIA VAV2 VAV2 ADCY1 ADCY1 ADCY4 ADCY4 PIK3R1 PIK3R1 PTK2B PTK2B CCR1 CCR1 CXCR6 CXCR6 CCR9 CCR9 CXCR4 CXCR4 CCL28 CCL28 ADCY2 ADCY2 GRK1 GRK1 ROCK1 ROCK1 GNB2 GNB2 CCL24 CCL24 CCL26 CCL26 NCF1 NCF1 GSK3A GSK3A PLCG2 PLCG2 CCR10 CCR10 STAT3 STAT3 STAT5B STAT5B GNG8 GNG8 CCR7 CCR7 CXCR5 CXCR5 GNGT2 GNGT2 PXN PXN RAC3 RAC3 NRAS NRAS RAP1A RAP1A GNAI3 GNAI3 VAV3 VAV3 PRKACB PRKACB GNG12 GNG12 PIK3R3 PIK3R3 FGR FGR CDC42 CDC42 PIK3CD PIK3CD PRKCZ PRKCZ GNB1 GNB1 PRKACG PRKACG XCR1 XCR1 CCR3 CCR3 CXCR2 CXCR2 CXCR1 CXCR1 CCR2 CCR2 CCR5 CCR5 CCR8 CCR8 CX3CR1 CX3CR1 CCR4 CCR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCAR1BCAR1 scaffold protein, Cas family member. (870 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
ARRB1Arrestin beta 1. (418 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
RAP1BUncharacterized protein. (184 aa)
CXCL13C-X-C motif chemokine. (109 aa)
CXCL11C-X-C motif chemokine. (83 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CXCL9C-X-C motif chemokine ligand 9. (125 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CXCL5C-X-C motif chemokine. (114 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
CXCL2C-X-C motif chemokine. (107 aa)
CXCL3C-X-C motif chemokine. (107 aa)
ENSCSAP00000001089C-X-C motif chemokine. (115 aa)
PPBPC-X-C motif chemokine. (126 aa)
PF4Platelet factor 4. (73 aa)
ENSCSAP00000001094C-X-C motif chemokine. (154 aa)
CXCL1C-X-C motif chemokine. (107 aa)
PF4V1C-X-C motif chemokine. (75 aa)
CXCL6C-X-C motif chemokine. (122 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
CCL17C-C motif chemokine. (91 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
CCL22C-C motif chemokine ligand 22. (93 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
PIK3R2Uncharacterized protein. (629 aa)
JAK3Tyrosine-protein kinase. (1069 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CCL3C-C motif chemokine. (92 aa)
ENSCSAP00000002431C-C motif chemokine. (92 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSCSAP00000002492C-C motif chemokine. (92 aa)
CCL18C-C motif chemokine. (88 aa)
CCL15C-C motif chemokine. (109 aa)
CCL14C-C motif chemokine. (67 aa)
CCL16C-C motif chemokine. (112 aa)
CCL5C-C motif chemokine. (91 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CCL8C-C motif chemokine. (109 aa)
CCL13C-C motif chemokine ligand 13; Belongs to the intercrine beta (chemokine CC) family. (98 aa)
CCL11C-C motif chemokine. (97 aa)
CCL2C-C motif chemokine. (99 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
CCL20C-C motif chemokine. (96 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
BADBCL2 associated agonist of cell death. (167 aa)
RASGRP2RAS guanyl releasing protein 2. (609 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
SHC3SHC adaptor protein 3. (598 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
RAC2Rac family small GTPase 2. (192 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
GNAQG protein subunit alpha q. (301 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (576 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
VAV1Vav guanine nucleotide exchange factor 1. (719 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1466 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
CCL27C-C motif chemokine ligand 27. (112 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
CCL19C-C motif chemokine. (98 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
GNB3G protein subunit beta 3. (340 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (749 aa)
SHC4SHC adaptor protein 4. (630 aa)
ITKTyrosine-protein kinase. (620 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC103230637SCY domain-containing protein. (114 aa)
LOC103230639SCY domain-containing protein. (114 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
GNB5G protein subunit beta 5. (353 aa)
PARD3Par-3 family cell polarity regulator. (1218 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (918 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (374 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
HCKTyrosine-protein kinase. (563 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNB4G protein subunit beta 4. (340 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
SHC2Uncharacterized protein. (590 aa)
CXCL16C-X-C motif chemokine ligand 16. (275 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
WASWASP actin nucleation promoting factor. (502 aa)
CXCL14C-X-C motif chemokine ligand 14. (111 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SRCTyrosine-protein kinase. (633 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
GNAI2G protein subunit alpha i2. (355 aa)
LYNTyrosine-protein kinase. (512 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1661 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
RHOARas homolog family member A. (193 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
FOXO3Forkhead box O3. (672 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
VAV2Vav guanine nucleotide exchange factor 2. (896 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CXCR6C-X-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (383 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CCL28C-C motif chemokine. (129 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (563 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
GNB2G protein subunit beta 2. (340 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
CCL26C-C motif chemokine. (94 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (591 aa)
RAC3Rac family small GTPase 3. (192 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
GNAI3G protein subunit alpha i3. (354 aa)
VAV3Vav guanine nucleotide exchange factor 3. (782 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FGRTyrosine-protein kinase. (529 aa)
CDC42Cell division cycle 42. (191 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (488 aa)
GNB1G protein subunit beta 1. (340 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CXCR2C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CXCR1C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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