101 items (Chlorocebus sabaeus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	TRADD	TNFRSF1A associated via death domain. (308 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	CXCL2	C-X-C motif chemokine. (107 aa)
	CXCL3	C-X-C motif chemokine. (107 aa)
	ENSCSAP00000001094	C-X-C motif chemokine. (154 aa)
	CXCL1	C-X-C motif chemokine. (107 aa)
	CSNK2A2	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (899 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
	TRIM25	Tripartite motif containing 25. (630 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	TNFRSF13C	TNF receptor superfamily member 13C. (146 aa)
	BLNK	B cell linker. (453 aa)
	ENSCSAP00000002431	C-C motif chemokine. (92 aa)
	ENSCSAP00000002492	C-C motif chemokine. (92 aa)
	CCL13	C-C motif chemokine ligand 13; Belongs to the intercrine beta (chemokine CC) family. (98 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (338 aa)
	LAT	Linker for activation of T cells. (235 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (686 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	SYK	Tyrosine-protein kinase. (635 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	ICAM1	Intercellular adhesion molecule 1. (532 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	ENSCSAP00000004095	Ig-like domain-containing protein. (166 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (548 aa)
	CSNK2B	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (228 aa)
	ENSCSAP00000005199	Ig-like domain-containing protein. (190 aa)
	PLAU	Plasminogen activator, urokinase. (437 aa)
	ENSCSAP00000005254	Ig-like domain-containing protein. (191 aa)
	ENSCSAP00000005267	Ig-like domain-containing protein. (146 aa)
	ENSCSAP00000005329	Ig-like domain-containing protein. (126 aa)
	ENSCSAP00000005377	Ig-like domain-containing protein. (139 aa)
	ENSCSAP00000005390	Ig-like domain-containing protein. (189 aa)
	LOC103229850	Ig-like domain-containing protein. (134 aa)
	ENSCSAP00000005509	Ig-like domain-containing protein. (162 aa)
	TNFSF14	TNF superfamily member 14; Belongs to the tumor necrosis factor family. (240 aa)
	EDARADD	EDAR associated death domain. (205 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	BTK	Tyrosine-protein kinase. (497 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	CCL19	C-C motif chemokine. (98 aa)
	CCL21	C-C motif chemokine ligand 21. (131 aa)
	CSNK2A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
	PIDD1	P53-induced death domain protein 1. (910 aa)
	LTBR	Lymphotoxin beta receptor. (435 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (455 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (160 aa)
	ERC1	ELKS/RAB6-interacting/CAST family member 1. (1120 aa)
	UBE2I	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (260 aa)
	EDA2R	Ectodysplasin A2 receptor. (299 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	TRAF1	TNF receptor-associated factor. (416 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (572 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (745 aa)
	LBP	Lipopolysaccharide binding protein. (481 aa)
	PLCG1	Phosphoinositide phospholipase C. (974 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	CD40	CD40 molecule. (278 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	BCL2A1	BCL2 related protein A1. (175 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa)
	NFKBIA	NFKB inhibitor alpha. (317 aa)
	TRAF2	TNF receptor-associated factor. (449 aa)
	PARP1	Poly(ADP-ribose) polymerase 1. (709 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	IL1R1	Interleukin 1 receptor type 1. (569 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	ZAP70	Tyrosine-protein kinase. (619 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	MALT1	MALT1 paracaspase. (729 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (561 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	XIAP	RING-type domain-containing protein. (497 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (440 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	CARD14	Caspase recruitment domain family member 14. (1004 aa)
	TIRAP	TIR domain containing adaptor protein. (220 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)
	BCL10	BCL10 immune signaling adaptor. (233 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	TICAM2	Toll like receptor adaptor molecule 2. (235 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (711 aa)
	ENSCSAP00000019090	Ig-like domain-containing protein. (103 aa)

Your Current Organism:

Chlorocebus sabaeus

NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BCL2	ENSCSAP00000015071	ENSCSAP00000014206	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.414
ATM	BTK	ENSCSAP00000015071	ENSCSAP00000006112	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.419
ATM	CHUK	ENSCSAP00000015071	ENSCSAP00000001972	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Component of inhibitor of nuclear factor kappa B kinase complex.	0.431
ATM	IKBKB	ENSCSAP00000015071	ENSCSAP00000011145	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.415
ATM	IKBKG	ENSCSAP00000015071	ENSCSAP00000003013	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.767
ATM	MAP3K7	ENSCSAP00000015071	ENSCSAP00000013306	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.446
ATM	NFKB1	ENSCSAP00000015071	ENSCSAP00000000407	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nuclear factor kappa B subunit 1.	0.454
ATM	PARP1	ENSCSAP00000015071	ENSCSAP00000012419	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Poly(ADP-ribose) polymerase 1.	0.465
ATM	PIDD1	ENSCSAP00000015071	ENSCSAP00000006779	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.713
ATM	UBE2I	ENSCSAP00000015071	ENSCSAP00000007972	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.602
BCL10	BCL2	ENSCSAP00000016593	ENSCSAP00000014206	BCL10 immune signaling adaptor.	BCL2 apoptosis regulator.	0.403
BCL10	CARD14	ENSCSAP00000016593	ENSCSAP00000015705	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 14.	0.744
BCL10	CHUK	ENSCSAP00000016593	ENSCSAP00000001972	BCL10 immune signaling adaptor.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.974
BCL10	DDX58	ENSCSAP00000016593	ENSCSAP00000006076	BCL10 immune signaling adaptor.	DExD/H-box helicase 58.	0.536
BCL10	IKBKB	ENSCSAP00000016593	ENSCSAP00000011145	BCL10 immune signaling adaptor.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.979
BCL10	IKBKG	ENSCSAP00000016593	ENSCSAP00000003013	BCL10 immune signaling adaptor.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.989
BCL10	MALT1	ENSCSAP00000016593	ENSCSAP00000014178	BCL10 immune signaling adaptor.	MALT1 paracaspase.	0.999
BCL10	MAP3K7	ENSCSAP00000016593	ENSCSAP00000013306	BCL10 immune signaling adaptor.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.959
BCL10	NFKB1	ENSCSAP00000016593	ENSCSAP00000000407	BCL10 immune signaling adaptor.	Nuclear factor kappa B subunit 1.	0.667
BCL10	NFKB2	ENSCSAP00000016593	ENSCSAP00000001753	BCL10 immune signaling adaptor.	Nuclear factor kappa B subunit 2.	0.463

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