STRINGSTRING
AKT2 AKT2 EGF EGF NFKB1 NFKB1 PRKCA PRKCA EIF4E EIF4E IFNG IFNG ENO4 ENO4 LDHAL6A LDHAL6A LDHC LDHC PIK3R2 PIK3R2 EP300 EP300 RBX1 RBX1 RPS6KB1 RPS6KB1 ALDOA ALDOA MAPK3 MAPK3 PFKM PFKM EIF4E2 EIF4E2 PRKCB PRKCB NOS3 NOS3 ALDOC ALDOC NOS2 NOS2 EDN1 EDN1 PFKL PFKL HKDC1 HKDC1 HK1 HK1 LDHB LDHB RELA RELA HMOX1 HMOX1 TFRC TFRC CDKN1B CDKN1B CAMK2G CAMK2G HK3 HK3 EIF4E1B EIF4E1B AKT3 AKT3 RPS6 RPS6 CREBBP CREBBP AKT1 AKT1 IFNGR2 IFNGR2 TEK TEK INS INS VHL VHL ENO2 ENO2 EGLN1 EGLN1 CDKN1A CDKN1A ELOB ELOB ANGPT4 ANGPT4 GAPDH GAPDH LTBR LTBR TF TF PGK1 PGK1 MAP2K2 MAP2K2 PIK3CB PIK3CB ALDOB ALDOB CUL2 CUL2 CAMK2A CAMK2A ANGPT1 ANGPT1 VEGFA VEGFA PDHB PDHB ENO3 ENO3 PIK3CA PIK3CA TLR4 TLR4 MAP2K1 MAP2K1 ELOC ELOC PFKFB3 PFKFB3 TIMP1 TIMP1 MAPK1 MAPK1 IL6 IL6 PLCG1 PLCG1 PFKP PFKP HIF1A HIF1A PDK1 PDK1 EIF4EBP1 EIF4EBP1 CAMK2B CAMK2B EGLN3 EGLN3 HK2 HK2 PIK3R1 PIK3R1 EGFR EGFR LDHA LDHA IFNGR1 IFNGR1 IGF1R IGF1R ANGPT2 ANGPT2 EPO EPO FLT1 FLT1 SERPINE1 SERPINE1 ARNT ARNT CYBB CYBB BCL2 BCL2 EGLN2 EGLN2 PLCG2 PLCG2 IGF1 IGF1 STAT3 STAT3 ERBB2 ERBB2 IL6R IL6R PRKCG PRKCG MKNK1 MKNK1 PIK3R3 PIK3R3 SLC2A1 SLC2A1 NPPA NPPA MTOR MTOR PIK3CD PIK3CD ENO1 ENO1 PDHA2 PDHA2 ENSCSAP00000018734 ENSCSAP00000018734 PGK2 PGK2 LDHAL6B LDHAL6B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
ENO4Enolase 4. (633 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (216 aa)
PIK3R2Uncharacterized protein. (629 aa)
EP300E1A binding protein p300. (2416 aa)
RBX1Ring-box 1. (108 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
NOS3Nitric oxide synthase 3. (867 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
EDN1Endothelin 1. (211 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (917 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
HMOX1Heme oxygenase 1. (288 aa)
TFRCTransferrin receptor. (774 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (588 aa)
HK3Hexokinase 3. (923 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (266 aa)
CREBBPCREB binding protein. (2417 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
TEKTEK receptor tyrosine kinase. (1123 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
ENO2Enolase 2. (434 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ELOBUbiquitin-like domain-containing protein. (118 aa)
ANGPT4Angiopoietin 4. (503 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
LTBRLymphotoxin beta receptor. (435 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
PGK1Phosphoglycerate kinase. (382 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
CUL2Cullin 2; Belongs to the cullin family. (842 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
ANGPT1Angiopoietin 1. (407 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
ENO3Enolase 3. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (475 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
IL6Interleukin 6. (212 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (807 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (628 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
HK2Hexokinase 2. (917 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (343 aa)
IFNGR1Interferon gamma receptor 1. (491 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
ANGPT2Angiopoietin 2. (495 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IGF1Insulin like growth factor 1. (159 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
IL6RInterleukin 6 receptor. (443 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (418 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (416 aa)
NPPANatriuretic peptide A. (153 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ENO1Enolase 1. (434 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
ENSCSAP00000018734Ubiquitin-like domain-containing protein. (118 aa)
PGK2Phosphoglycerate kinase. (417 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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