STRINGSTRING
GABARAPL2 GABARAPL2 AKT2 AKT2 EGF EGF MDM2 MDM2 MAPK10 MAPK10 BNIP3 BNIP3 CCNG2 CCNG2 AGAP2 AGAP2 GRB2 GRB2 MAPK11 MAPK11 HOMER3 HOMER3 CDK2 CDK2 RBL2 RBL2 PIK3R2 PIK3R2 CAT CAT RAG1 RAG1 CHUK CHUK KLF2 KLF2 EP300 EP300 PRKAG1 PRKAG1 MAPK3 MAPK3 PRKAG2 PRKAG2 CSNK1E CSNK1E PLK1 PLK1 PTEN PTEN CDKN2D CDKN2D GADD45G GADD45G NLK NLK SIRT1 SIRT1 KRAS KRAS BRAF BRAF MAPK9 MAPK9 CDKN1B CDKN1B PRKAG3 PRKAG3 USP7 USP7 GABARAPL1 GABARAPL1 BCL6 BCL6 CCND1 CCND1 AKT3 AKT3 RAF1 RAF1 TGFBR2 TGFBR2 CREBBP CREBBP AKT1 AKT1 CDKN2B CDKN2B INS INS MAPK8 MAPK8 MAPK14 MAPK14 MAPK13 MAPK13 CDKN1A CDKN1A FBXO32 FBXO32 MAP2K2 MAP2K2 HRAS HRAS TGFBR1 TGFBR1 PIK3CB PIK3CB CCND2 CCND2 GADD45B GADD45B FOXO4 FOXO4 FASLG FASLG SLC2A4 SLC2A4 GABARAP GABARAP TGFB3 TGFB3 CCNB2 CCNB2 STK11 STK11 SOS1 SOS1 SOD2 SOD2 CCNB3 CCNB3 TNFSF10 TNFSF10 PIK3CA PIK3CA MAP2K1 MAP2K1 SMAD3 SMAD3 ARAF ARAF MAPK1 MAPK1 IL6 IL6 SGK2 SGK2 SGK3 SGK3 STK4 STK4 ATG12 ATG12 IL10 IL10 IKBKB IKBKB FOXO3 FOXO3 SOS2 SOS2 HOMER1 HOMER1 PCK1 PCK1 CCNB1 CCNB1 PIK3R1 PIK3R1 EGFR EGFR PLK2 PLK2 PCK2 PCK2 SGK1 SGK1 PRKAA1 PRKAA1 IGF1R IGF1R SKP2 SKP2 IL7R IL7R FBXO25 FBXO25 GRM1 GRM1 HOMER2 HOMER2 IRS2 IRS2 FOXO1 FOXO1 SMAD4 SMAD4 PDPK1 PDPK1 PRKAB2 PRKAB2 PLK4 PLK4 TGFB1 TGFB1 SETD7 SETD7 G6PC3 G6PC3 G6PC G6PC IGF1 IGF1 STAT3 STAT3 ATM ATM PRMT1 PRMT1 PRKAB1 PRKAB1 NRAS NRAS GADD45A GADD45A PRKAA2 PRKAA2 PIK3R3 PIK3R3 PLK3 PLK3 PIK3CD PIK3CD IRS4 IRS4 S1PR1 S1PR1 S1PR4 S1PR4 RAG2 RAG2 FOXG1 FOXG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1195 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
HOMER3WH1 domain-containing protein. (361 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
PIK3R2Uncharacterized protein. (629 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
KLF2Kruppel like factor 2. (355 aa)
EP300E1A binding protein p300. (2416 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (524 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (431 aa)
PLK1Serine/threonine-protein kinase PLK. (569 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
NLKMitogen-activated protein kinase. (376 aa)
SIRT1Sirtuin 1. (743 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (464 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1102 aa)
GABARAPL1GABA type A receptor associated protein like 1. (117 aa)
BCL6BCL6 transcription repressor. (708 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
CREBBPCREB binding protein. (2417 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (137 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
FBXO32F-box protein 32. (355 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
FOXO4Forkhead box O4. (505 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (282 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1324 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
IL6Interleukin 6. (212 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
STK4Serine/threonine kinase 4. (487 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
IL10Interleukin 10. (178 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
FOXO3Forkhead box O3. (672 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
HOMER1Homer scaffold protein 1. (354 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (429 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
PRKAA1Non-specific serine/threonine protein kinase. (501 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
IL7RInterleukin 7 receptor. (459 aa)
FBXO25F-box protein 25. (367 aa)
GRM1G_PROTEIN_RECEP_F3_4 domain-containing protein. (878 aa)
HOMER2Homer scaffold protein 2. (343 aa)
IRS2Insulin receptor substrate 2. (906 aa)
FOXO1Forkhead box O1. (655 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PLK4Polo like kinase 4. (970 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
IGF1Insulin like growth factor 1. (159 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (306 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
S1PR4Sphingosine-1-phosphate receptor 4. (384 aa)
RAG2Recombination activating 2. (527 aa)
FOXG1Forkhead box G1. (490 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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