STRINGSTRING
AKT2 AKT2 KITLG KITLG GAB2 GAB2 EGF EGF GNA13 GNA13 PRKCA PRKCA AVPR1A AVPR1A RRAS2 RRAS2 GRB2 GRB2 CXCL8 CXCL8 PDGFRA PDGFRA KIT KIT SPHK1 SPHK1 LPAR2 LPAR2 DGKA DGKA ADCY7 ADCY7 PIK3R2 PIK3R2 DGKE DGKE DGKZ DGKZ ZNF408 ZNF408 MS4A2 MS4A2 MAPK3 MAPK3 ADCY6 ADCY6 DGKD DGKD PDGFB PDGFB RAPGEF3 RAPGEF3 RHEB RHEB AVPR2 AVPR2 DNM2 DNM2 PLCB3 PLCB3 SYK SYK SHC3 SHC3 PLCB2 PLCB2 CYTH4 CYTH4 ADCY5 ADCY5 KRAS KRAS PLA2G4B PLA2G4B AGPAT3 AGPAT3 PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F PIP5K1B PIP5K1B GRM6 GRM6 ADCY3 ADCY3 ENSCSAP00000005199 ENSCSAP00000005199 ENSCSAP00000005254 ENSCSAP00000005254 ENSCSAP00000005267 ENSCSAP00000005267 ENSCSAP00000005329 ENSCSAP00000005329 ENSCSAP00000005377 ENSCSAP00000005377 ENSCSAP00000005390 ENSCSAP00000005390 LOC103229850 LOC103229850 ENSCSAP00000005509 ENSCSAP00000005509 AGPAT1 AGPAT1 AKT3 AKT3 RAF1 RAF1 ADCY9 ADCY9 AKT1 AKT1 GRM4 GRM4 INS INS ADCY8 ADCY8 GRM8 GRM8 PIK3R5 PIK3R5 PIK3R6 PIK3R6 SHC4 SHC4 AGT AGT MAP2K2 MAP2K2 MRAS MRAS HRAS HRAS TSC2 TSC2 PIP5K1C PIP5K1C PIK3CB PIK3CB PIK3CG PIK3CG AGTR1 AGTR1 DNM3 DNM3 PDGFRB PDGFRB LPAR1 LPAR1 AGPAT4 AGPAT4 GRM3 GRM3 SOS1 SOS1 DGKK DGKK PLD1 PLD1 PIK3CA PIK3CA PLD2 PLD2 SHC2 SHC2 PLPP2 PLPP2 MAP2K1 MAP2K1 AVP AVP PLA2G4A PLA2G4A DGKB DGKB PLCB1 PLCB1 PLCB4 PLCB4 MAPK1 MAPK1 PLCG1 PLCG1 GRM2 GRM2 DGKG DGKG DNM1 DNM1 RAPGEF4 RAPGEF4 AVPR1B AVPR1B TSC1 TSC1 RHOA RHOA SOS2 SOS2 RALA RALA F2R F2R DGKQ DGKQ GNAS GNAS FYN FYN ADCY1 ADCY1 ADCY4 ADCY4 AGPAT2 AGPAT2 PIK3R1 PIK3R1 PTK2B PTK2B EGFR EGFR ARF1 ARF1 RALB RALB GRM1 GRM1 ADCY2 ADCY2 PDGFA PDGFA GNA12 GNA12 CYTH3 CYTH3 DGKH DGKH GRM5 GRM5 GAB1 GAB1 PLCG2 PLCG2 PDGFC PDGFC PDGFD PDGFD CYTH2 CYTH2 SPHK2 SPHK2 FCER1G FCER1G RRAS RRAS PTPN11 PTPN11 FCER1A FCER1A CYTH1 CYTH1 PIP5K1A PIP5K1A NRAS NRAS LPAR3 LPAR3 PTGFR PTGFR PLPP3 PLPP3 PIK3R3 PIK3R3 MTOR MTOR PIK3CD PIK3CD LPAR4 LPAR4 LPAR6 LPAR6 LOC103243499 LOC103243499 CXCR2 CXCR2 CXCR1 CXCR1 LPAR5 LPAR5 ARF6 ARF6 ENSCSAP00000019090 ENSCSAP00000019090
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GNA13G protein subunit alpha 13. (377 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
RRAS2RAS related 2. (204 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
SPHK1Sphingosine kinase 1. (472 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
DGKADiacylglycerol kinase. (737 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
PIK3R2Uncharacterized protein. (629 aa)
DGKEDiacylglycerol kinase. (567 aa)
DGKZDiacylglycerol kinase. (929 aa)
ZNF408Zinc finger protein 408. (719 aa)
MS4A2Membrane spanning 4-domains A2. (245 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
DGKDDiacylglycerol kinase. (1156 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
RHEBRas homolog, mTORC1 binding. (173 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (368 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
SYKTyrosine-protein kinase. (635 aa)
SHC3SHC adaptor protein 3. (598 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
CYTH4Cytohesin 4. (337 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PLA2G4BPhospholipase A2. (1012 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
PLA2G4EPhospholipase A2. (869 aa)
PLA2G4DPhospholipase A2. (825 aa)
PLA2G4FPhospholipase A2. (853 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (502 aa)
GRM6Glutamate metabotropic receptor 6. (877 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ENSCSAP00000005199Ig-like domain-containing protein. (190 aa)
ENSCSAP00000005254Ig-like domain-containing protein. (191 aa)
ENSCSAP00000005267Ig-like domain-containing protein. (146 aa)
ENSCSAP00000005329Ig-like domain-containing protein. (126 aa)
ENSCSAP00000005377Ig-like domain-containing protein. (139 aa)
ENSCSAP00000005390Ig-like domain-containing protein. (189 aa)
LOC103229850Ig-like domain-containing protein. (134 aa)
ENSCSAP00000005509Ig-like domain-containing protein. (162 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (290 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GRM4Glutamate metabotropic receptor 4. (740 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (749 aa)
SHC4SHC adaptor protein 4. (630 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TSC2TSC complex subunit 2. (1806 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (668 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (918 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
DGKKDiacylglycerol kinase. (1273 aa)
PLD1Phospholipase. (1074 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLD2Phospholipase. (960 aa)
SHC2Uncharacterized protein. (590 aa)
PLPP2Phospholipid phosphatase 2. (288 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
PLA2G4APhospholipase A2. (749 aa)
DGKBDiacylglycerol kinase. (706 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
GRM2Glutamate metabotropic receptor 2. (961 aa)
DGKGDiacylglycerol kinase. (791 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (775 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
TSC1TSC complex subunit 1. (1164 aa)
RHOARas homolog family member A. (193 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RALARAS like proto-oncogene A. (206 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
DGKQDiacylglycerol kinase. (941 aa)
GNASUncharacterized protein. (335 aa)
FYNTyrosine-protein kinase. (537 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
RALBRAS like proto-oncogene B. (206 aa)
GRM1G_PROTEIN_RECEP_F3_4 domain-containing protein. (878 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
GNA12G protein subunit alpha 12. (305 aa)
CYTH3Cytohesin 3. (399 aa)
DGKHDiacylglycerol kinase. (1220 aa)
GRM5Glutamate metabotropic receptor 5. (729 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
PDGFDPlatelet derived growth factor D. (332 aa)
CYTH2Uncharacterized protein. (552 aa)
SPHK2Sphingosine kinase 2. (653 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
RRASRAS related. (218 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
FCER1AFc fragment of IgE receptor Ia. (257 aa)
CYTH1Cytohesin 1. (400 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (425 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PLPP3acidPPc domain-containing protein. (353 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
LOC103243499Uncharacterized protein. (251 aa)
CXCR2C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CXCR1C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ENSCSAP00000019090Ig-like domain-containing protein. (103 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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