STRINGSTRING
CDC27 CDC27 WWP2 WWP2 HERC3 HERC3 MDM2 MDM2 UBA2 UBA2 RCHY1 RCHY1 UBE2O UBE2O UBA6 UBA6 UBA52 UBA52 SIAH1 SIAH1 TRAF6 TRAF6 BTRC BTRC DDB2 DDB2 TRIM37 TRIM37 RBX1 RBX1 UBE2L6 UBE2L6 PRPF19 PRPF19 CBLB CBLB DDB1 DDB1 UBE3A UBE3A UBE3C UBE3C HERC2 HERC2 TRIP12 TRIP12 CUL1 CUL1 KEAP1 KEAP1 UBE2D1 UBE2D1 RHOBTB1 RHOBTB1 HERC4 HERC4 UBE2G2 UBE2G2 SYVN1 SYVN1 CUL3 CUL3 UBB UBB MGRN1 MGRN1 FBXW11 FBXW11 UBE2E1 UBE2E1 UBE2E2 UBE2E2 UBE2H UBE2H UBE2R2 UBE2R2 VHL VHL ELOB ELOB ANAPC13 ANAPC13 FZR1 FZR1 RNF7 RNF7 CUL2 CUL2 CUL7 CUL7 BIRC6 BIRC6 UBA3 UBA3 UBE2I UBE2I NEDD4 NEDD4 UBR5 UBR5 COP1 COP1 ITCH ITCH PRKN PRKN STUB1 STUB1 HERC1 HERC1 CDC26 CDC26 HUWE1 HUWE1 UBE2E3 UBE2E3 WWP1 WWP1 CDC34 CDC34 UBE2G1 UBE2G1 CDC23 CDC23 UBOX5 UBOX5 PIAS1 PIAS1 PPIL2 PPIL2 ELOC ELOC UBE2B UBE2B SKP1 SKP1 UBA1 UBA1 PML PML RPS27A RPS27A FANCL FANCL UBA7 UBA7 UBE2Q2 UBE2Q2 MID1 MID1 UBE2D4 UBE2D4 ERCC8 ERCC8 MAP3K1 MAP3K1 RHOBTB2 RHOBTB2 ANAPC2 ANAPC2 ANAPC4 ANAPC4 ENSCSAP00000012800 ENSCSAP00000012800 FBXO4 FBXO4 ANAPC1 ANAPC1 UBE2K UBE2K SKP2 SKP2 DET1 DET1 UBE2J1 UBE2J1 ENSCSAP00000013347 ENSCSAP00000013347 UBE2QL1 UBE2QL1 CUL4A CUL4A SMURF1 SMURF1 PIAS2 PIAS2 NEDD4L NEDD4L KLHL13 KLHL13 XIAP XIAP CUL4B CUL4B UBE2A UBE2A ANAPC10 ANAPC10 BRCA1 BRCA1 FBXW7 FBXW7 CBLC CBLC CUL5 CUL5 SAE1 SAE1 UBE3B UBE3B ANAPC7 ANAPC7 UBE4A UBE4A CBL CBL UBE2Z UBE2Z FBXW8 FBXW8 ANAPC11 ANAPC11 ANAPC5 ANAPC5 UBC UBC UBE2Q1 UBE2Q1 PIAS3 PIAS3 UBE2S UBE2S UBE2M UBE2M UBE2U UBE2U CDC20 CDC20 FBXO2 FBXO2 UBE2J2 UBE2J2 TRIM32 TRIM32 ENSCSAP00000017576 ENSCSAP00000017576 UBE2NL UBE2NL UBE2C UBE2C SOCS1 SOCS1 ENSCSAP00000018444 ENSCSAP00000018444 SOCS3 SOCS3 NHLRC1 NHLRC1 ENSCSAP00000018734 ENSCSAP00000018734
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC27Cell division cycle 27. (824 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
HERC3HECT domain-containing protein. (1050 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
UBA2SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (641 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1293 aa)
UBA6Ubiquitin like modifier activating enzyme 6. (1052 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
TRIM37Tripartite motif containing 37. (963 aa)
RBX1Ring-box 1. (108 aa)
UBE2L6Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
CBLBCbl proto-oncogene B. (982 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (872 aa)
UBE3CUbiquitin protein ligase E3C. (1083 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4834 aa)
TRIP12Thyroid hormone receptor interactor 12. (2067 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
RHOBTB1Rho related BTB domain containing 1. (696 aa)
HERC4HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1057 aa)
UBE2G2Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (164 aa)
SYVN1Synoviolin 1. (617 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
UBBUncharacterized protein. (153 aa)
MGRN1Mahogunin ring finger 1. (576 aa)
FBXW11F-box and WD repeat domain containing 11. (510 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
UBE2E2Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (130 aa)
UBE2HUbiquitin conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
UBE2R2Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
ELOBUbiquitin-like domain-containing protein. (118 aa)
ANAPC13Anaphase promoting complex subunit 13. (74 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
RNF7Ring finger protein 7. (113 aa)
CUL2Cullin 2; Belongs to the cullin family. (842 aa)
CUL7Cullin 7; Belongs to the cullin family. (1697 aa)
BIRC6Baculoviral IAP repeat containing 6. (4880 aa)
UBA3Ubiquitin like modifier activating enzyme 3. (463 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
NEDD4E3 ubiquitin-protein ligase. (900 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2793 aa)
COP1COP1 E3 ubiquitin ligase. (759 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
PRKNParkin RBR E3 ubiquitin protein ligase. (288 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4846 aa)
CDC26Cell division cycle 26. (85 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4374 aa)
UBE2E3Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
WWP1WW domain containing E3 ubiquitin protein ligase 1. (684 aa)
CDC34Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (236 aa)
UBE2G1Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
CDC23Cell division cycle 23. (597 aa)
UBOX5U-box domain containing 5. (529 aa)
PIAS1Protein inhibitor of activated STAT 1. (651 aa)
PPIL2Peptidylprolyl isomerase like 2. (521 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
UBE2BUbiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
UBA1Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1058 aa)
PMLPromyelocytic leukemia. (819 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
FANCLFA complementation group L. (461 aa)
UBA7Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1012 aa)
UBE2Q2Ubiquitin conjugating enzyme E2 Q2. (375 aa)
MID1Midline 1. (667 aa)
UBE2D4Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (177 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1345 aa)
RHOBTB2Rho related BTB domain containing 2. (727 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (786 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
ENSCSAP00000012800UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
FBXO4F-box protein 4. (387 aa)
ANAPC1Anaphase promoting complex subunit 1. (1944 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
DET1Uncharacterized protein. (550 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
ENSCSAP00000013347Uncharacterized protein. (184 aa)
UBE2QL1Ubiquitin conjugating enzyme E2 Q family like 1. (305 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
SMURF1E3 ubiquitin-protein ligase. (728 aa)
PIAS2Protein inhibitor of activated STAT 2. (572 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (993 aa)
KLHL13Kelch like family member 13. (655 aa)
XIAPRING-type domain-containing protein. (497 aa)
CUL4BCullin 4B; Belongs to the cullin family. (900 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
BRCA1Uncharacterized protein. (663 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
CBLCCbl proto-oncogene C. (495 aa)
CUL5Cullin 5; Belongs to the cullin family. (780 aa)
SAE1SUMO1 activating enzyme subunit 1. (310 aa)
UBE3BUbiquitin protein ligase E3B. (1068 aa)
ANAPC7Anaphase promoting complex subunit 7. (346 aa)
UBE4AUbiquitination factor E4A. (1066 aa)
CBLCbl proto-oncogene. (907 aa)
UBE2ZUbiquitin conjugating enzyme E2 Z. (354 aa)
FBXW8F-box and WD repeat domain containing 8. (596 aa)
ANAPC11RING-type domain-containing protein. (84 aa)
ANAPC5Anaphase promoting complex subunit 5. (742 aa)
UBCUncharacterized protein. (228 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (422 aa)
PIAS3Protein inhibitor of activated STAT 3. (542 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
UBE2UUbiquitin conjugating enzyme E2 U; Belongs to the ubiquitin-conjugating enzyme family. (226 aa)
CDC20Cell division cycle 20. (499 aa)
FBXO2F-box protein 2. (297 aa)
UBE2J2Ubiquitin conjugating enzyme E2 J2. (259 aa)
TRIM32Tripartite motif containing 32. (653 aa)
ENSCSAP00000017576UBIQUITIN_CONJUGAT_2 domain-containing protein. (175 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
ENSCSAP00000018444Ubiquitin-like domain-containing protein. (127 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1. (395 aa)
ENSCSAP00000018734Ubiquitin-like domain-containing protein. (118 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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