STRINGSTRING
AKT2 AKT2 NFKB1 NFKB1 EIF4E EIF4E ADCY7 ADCY7 PIK3R2 PIK3R2 CAT CAT CREB3L1 CREB3L1 ATG13 ATG13 ATG101 ATG101 RPS6KB1 RPS6KB1 PRKAG1 PRKAG1 ADCY6 ADCY6 ATF4 ATF4 EIF4E2 EIF4E2 PRKAG2 PRKAG2 RHEB RHEB SIRT1 SIRT1 ADCY5 ADCY5 KRAS KRAS RELA RELA ADCY3 ADCY3 PRKAG3 PRKAG3 CREB3L2 CREB3L2 EHMT2 EHMT2 EIF4E1B EIF4E1B ADIPOQ ADIPOQ ATF6B ATF6B AKT3 AKT3 ADCY9 ADCY9 AKT1 AKT1 INS INS PPARG PPARG ADCY8 ADCY8 CREB1 CREB1 CREB3 CREB3 CREB3L3 CREB3L3 HRAS HRAS TSC2 TSC2 PIK3CB PIK3CB TP53 TP53 ADIPOR2 ADIPOR2 STK11 STK11 SOD2 SOD2 APPL1 APPL1 PIK3CA PIK3CA ADIPOR1 ADIPOR1 CREB5 CREB5 ATF2 ATF2 RB1CC1 RB1CC1 ATG5 ATG5 CAMK4 CAMK4 TSC1 TSC1 FOXO3 FOXO3 SESN1 SESN1 EIF4EBP1 EIF4EBP1 ADCY1 ADCY1 ADCY4 ADCY4 PIK3R1 PIK3R1 PPARGC1A PPARGC1A EHMT1 EHMT1 PRKAA1 PRKAA1 IGF1R IGF1R ADCY2 ADCY2 IRS2 IRS2 FOXO1 FOXO1 KL KL PRKAB2 PRKAB2 IGF1 IGF1 SESN3 SESN3 BAX BAX AKT1S1 AKT1S1 RPTOR RPTOR PRKAB1 PRKAB1 ULK1 ULK1 NRAS NRAS PRKACB PRKACB PRKAA2 PRKAA2 PIK3R3 PIK3R3 SESN2 SESN2 MTOR MTOR PIK3CD PIK3CD IRS4 IRS4 PRKACG PRKACG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
PIK3R2Uncharacterized protein. (629 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
ATG101Autophagy related 101. (218 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATF4Activating transcription factor 4. (351 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (524 aa)
RHEBRas homolog, mTORC1 binding. (173 aa)
SIRT1Sirtuin 1. (743 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (464 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1197 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (311 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TSC2TSC complex subunit 2. (1806 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (501 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (614 aa)
TSC1TSC complex subunit 1. (1164 aa)
FOXO3Forkhead box O3. (672 aa)
SESN1Sestrin 1. (492 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1267 aa)
PRKAA1Non-specific serine/threonine protein kinase. (501 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
IRS2Insulin receptor substrate 2. (906 aa)
FOXO1Forkhead box O1. (655 aa)
KLKlotho. (1010 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
IGF1Insulin like growth factor 1. (159 aa)
SESN3Sestrin 3. (492 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
AKT1S1AKT1 substrate 1. (256 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1070 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SESN2Sestrin 2. (480 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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