STRINGSTRING
AKT2 AKT2 CLPB CLPB ADCY7 ADCY7 PIK3R2 PIK3R2 CAT CAT RPS6KB1 RPS6KB1 PRKAG1 PRKAG1 ADCY6 ADCY6 PRKAG2 PRKAG2 SIRT1 SIRT1 ADCY5 ADCY5 KRAS KRAS EIF4EBP2 EIF4EBP2 ADCY3 ADCY3 PRKAG3 PRKAG3 AKT3 AKT3 ADCY9 ADCY9 AKT1 AKT1 INS INS ADCY8 ADCY8 HRAS HRAS FOXA2 FOXA2 PIK3CB PIK3CB SOD2 SOD2 PIK3CA PIK3CA ATG5 ATG5 FOXO3 FOXO3 HDAC2 HDAC2 ADCY1 ADCY1 ADCY4 ADCY4 PIK3R1 PIK3R1 PRKAA1 PRKAA1 IGF1R IGF1R ADCY2 ADCY2 IRS2 IRS2 FOXO1 FOXO1 PRKAB2 PRKAB2 IGF1 IGF1 CRYAB CRYAB AKT1S1 AKT1S1 HSPA8 HSPA8 RPTOR RPTOR PRKAB1 PRKAB1 ENSCSAP00000016053 ENSCSAP00000016053 NRAS NRAS PRKACB PRKACB PRKAA2 PRKAA2 PIK3R3 PIK3R3 HDAC1 HDAC1 MTOR MTOR PIK3CD PIK3CD IRS4 IRS4 PRKACG PRKACG HSPA1A HSPA1A HSPA1L HSPA1L HSPA2 HSPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (677 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
PIK3R2Uncharacterized protein. (629 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (524 aa)
SIRT1Sirtuin 1. (743 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (120 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (464 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FOXA2Forkhead box A2. (463 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
FOXO3Forkhead box O3. (672 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKAA1Non-specific serine/threonine protein kinase. (501 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
IRS2Insulin receptor substrate 2. (906 aa)
FOXO1Forkhead box O1. (655 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
IGF1Insulin like growth factor 1. (159 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
AKT1S1AKT1 substrate 1. (256 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ENSCSAP00000016053Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (497 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
HSPA1AUncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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