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AKT2 AKT2 ATP2B1 ATP2B1 PRKCA PRKCA CACNG5 CACNG5 CACNG4 CACNG4 CACNG1 CACNG1 PPP2R2D PPP2R2D SCN1B SCN1B MAPK11 MAPK11 ADCY7 ADCY7 PPP1R1A PPP1R1A CREB3L1 CREB3L1 TPM4 TPM4 MAPK3 MAPK3 CACNB3 CACNB3 ADCY6 ADCY6 ATP2A1 ATP2A1 ATF4 ATF4 RAPGEF3 RAPGEF3 CACNG3 CACNG3 ATP2B3 ATP2B3 PLCB3 PLCB3 ACTC1 ACTC1 PLCB2 PLCB2 PPP2R5B PPP2R5B ADCY5 ADCY5 GNAQ GNAQ CACNG2 CACNG2 ADCY3 ADCY3 PPP1CA PPP1CA CREB3L2 CREB3L2 CAMK2G CAMK2G ATF6B ATF6B AKT3 AKT3 KCNQ1 KCNQ1 ADCY9 ADCY9 RYR2 RYR2 AKT1 AKT1 ATP2B2 ATP2B2 ADCY8 ADCY8 CREB1 CREB1 MAPK14 MAPK14 MAPK13 MAPK13 PPP2R5C PPP2R5C PIK3R5 PIK3R5 PIK3R6 PIK3R6 ADRA1B ADRA1B TPM2 TPM2 CREB3 CREB3 AGT AGT PPP1CB PPP1CB CREB3L3 CREB3L3 PPP2R3A PPP2R3A ATP1B1 ATP1B1 ATP1B3 ATP1B3 CACNA1C CACNA1C ATP1B2 ATP1B2 CREM CREM CACNA2D4 CACNA2D4 PIK3CG PIK3CG RPS6KA5 RPS6KA5 AGTR1 AGTR1 CALM1 CALM1 PPP2R5D PPP2R5D CAMK2A CAMK2A GNAI1 GNAI1 CACNA2D1 CACNA2D1 PPP2R2B PPP2R2B TPM1 TPM1 SLC8A1 SLC8A1 CACNB2 CACNB2 CACNA1F CACNA1F ADRA1D ADRA1D CACNA2D3 CACNA2D3 CACNA1D CACNA1D SLC8A3 SLC8A3 TNNC1 TNNC1 CALML4 CALML4 ATP2A3 ATP2A3 PLCB1 PLCB1 PLCB4 PLCB4 PPP2CA PPP2CA MAPK1 MAPK1 CACNA1S CACNA1S TNNT2 TNNT2 PPP2R5E PPP2R5E CACNA2D2 CACNA2D2 GNAI2 GNAI2 CREB5 CREB5 ATP2B4 ATP2B4 ATF2 ATF2 SCN5A SCN5A RAPGEF4 RAPGEF4 SCN7A SCN7A PPP2R5A PPP2R5A PPP2R3C PPP2R3C GNAS GNAS CAMK2B CAMK2B ADCY1 ADCY1 PPP2CB PPP2CB ADCY4 ADCY4 MYH7 MYH7 MYH6 MYH6 ADRA1A ADRA1A CACNB4 CACNB4 PPP2R2A PPP2R2A PPP2R2C PPP2R2C MYL3 MYL3 ADCY2 ADCY2 BCL2 BCL2 ATP1B4 ATP1B4 PPP2R3B PPP2R3B ATP1A3 ATP1A3 SLC8A2 SLC8A2 PPP2R1B PPP2R1B ATP2A2 ATP2A2 FXYD2 FXYD2 PPP1CC PPP1CC MYL2 MYL2 ATP1A4 ATP1A4 ATP1A2 ATP1A2 PPP2R1A PPP2R1A CACNG7 CACNG7 CACNG8 CACNG8 CACNG6 CACNG6 TNNI3 TNNI3 ATP1A1 ATP1A1 GNAI3 GNAI3 PRKACB PRKACB SLC9A1 SLC9A1 ADRB1 ADRB1 PRKACG PRKACG KCNE1 KCNE1 LOC103243499 LOC103243499 PLN PLN CALML5 CALML5 CALML3 CALML3 AGTR2 AGTR2 ADRB2 ADRB2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AKT2Non-specific serine/threonine protein kinase. (535 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1176 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (278 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (458 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (218 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
PPP1R1AProtein phosphatase 1 regulatory inhibitor subunit 1A. (171 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
TPM4Tropomyosin 4; Belongs to the tropomyosin family. (286 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (994 aa)
ATF4Activating transcription factor 4. (351 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1173 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
GNAQG protein subunit alpha q. (301 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (588 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (518 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
RYR2Ryanodine receptor 2. (4906 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1199 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (749 aa)
ADRA1BAdrenoceptor alpha 1B; Belongs to the G-protein coupled receptor 1 family. (317 aa)
TPM2Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (311 aa)
PPP2R3AUncharacterized protein. (529 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (265 aa)
CACNA1CCalcium voltage-gated channel subunit alpha1 C. (1898 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
CREMcAMP responsive element modulator. (299 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1137 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (918 aa)
RPS6KA5Ribosomal protein S6 kinase. (776 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (962 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
TPM1Tropomyosin 1; Belongs to the tropomyosin family. (284 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (632 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (612 aa)
CACNA1FIon_trans domain-containing protein. (233 aa)
ADRA1DAdrenoceptor alpha 1D. (570 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1034 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2036 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
CALML4Calmodulin like 4. (194 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1038 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (435 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1074 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (501 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1170 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1680 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
GNASUncharacterized protein. (335 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (628 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1501 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1942 aa)
ADRA1AAdrenoceptor alpha 1A. (425 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (486 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
MYL3Myosin light chain 3. (197 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
PPP2R3BEF-hand domain-containing protein. (575 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1013 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (599 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (997 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
MYL2Myosin light chain 2. (166 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (421 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ADRB1Adrenoceptor beta 1. (482 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
KCNE1Uncharacterized protein. (146 aa)
LOC103243499Uncharacterized protein. (251 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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