STRINGSTRING
ARRB1 ARRB1 GLI1 GLI1 SUFU SUFU BTRC BTRC DHH DHH PTCH1 PTCH1 SHH SHH BOC BOC CSNK1E CSNK1E CUL1 CUL1 GSK3B GSK3B MOSMO MOSMO CUL3 CUL3 IHH IHH GRK2 GRK2 MGRN1 MGRN1 CCND1 CCND1 FBXW11 FBXW11 SMO SMO GRK3 GRK3 GPR161 GPR161 CCND2 CCND2 CSNK1A1 CSNK1A1 CSNK1G2 CSNK1G2 CSNK1G1 CSNK1G1 KIF3A KIF3A CSNK1G3 CSNK1G3 LRP2 LRP2 GLI3 GLI3 EVC EVC EVC2 EVC2 SPOPL SPOPL GLI2 GLI2 KIF7 KIF7 SMURF1 SMURF1 BCL2 BCL2 MEGF8 MEGF8 HHIP HHIP CDON CDON CSNK1D CSNK1D PRKACB PRKACB PTCH2 PTCH2 PRKACG PRKACG GAS1 GAS1 CSNK1A1L CSNK1A1L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARRB1Arrestin beta 1. (418 aa)
GLI1GLI family zinc finger 1. (1106 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
DHHDesert hedgehog signaling molecule. (298 aa)
PTCH1Patched 1. (1452 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1115 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (431 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
MOSMOModulator of smoothened. (167 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
MGRN1Mahogunin ring finger 1. (576 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
FBXW11F-box and WD repeat domain containing 11. (510 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (529 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (353 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (415 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (459 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (456 aa)
LRP2LDL receptor related protein 2. (3861 aa)
GLI3GLI family zinc finger 3. (1459 aa)
EVCEvC ciliary complex subunit 1. (948 aa)
EVC2EvC ciliary complex subunit 2. (1311 aa)
SPOPLSpeckle type BTB/POZ protein like. (288 aa)
GLI2GLI family zinc finger 2. (1554 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1343 aa)
SMURF1E3 ubiquitin-protein ligase. (728 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
HHIPHedgehog interacting protein. (682 aa)
CDONCell adhesion associated, oncogene regulated. (1287 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (409 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
PTCH2Patched 2. (1203 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
GAS1Growth arrest specific 1. (347 aa)
CSNK1A1LCasein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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