STRINGSTRING
AKT2 AKT2 GAB2 GAB2 ITGB3 ITGB3 NFKB1 NFKB1 PPP3CA PPP3CA TYROBP TYROBP IFNG IFNG MAPK10 MAPK10 MAP2K6 MAP2K6 GRB2 GRB2 MAPK11 MAPK11 STAT2 STAT2 CYLD CYLD PIK3R2 PIK3R2 NFKB2 NFKB2 TRAF6 TRAF6 CHUK CHUK BLNK BLNK MAPK3 MAPK3 TAB1 TAB1 ACP5 ACP5 IKBKG IKBKG SYK SYK NCF4 NCF4 RELA RELA FOSL1 FOSL1 MAP2K7 MAP2K7 MAPK9 MAPK9 SQSTM1 SQSTM1 PPP3CB PPP3CB AKT3 AKT3 TGFBR2 TGFBR2 AKT1 AKT1 IFNAR2 IFNAR2 IFNAR1 IFNAR1 IFNGR2 IFNGR2 PPARG PPARG BTK BTK LCP2 LCP2 CREB1 CREB1 MAPK8 MAPK8 MAPK14 MAPK14 MAPK13 MAPK13 FOSL2 FOSL2 NOX1 NOX1 SIRPD SIRPD LOC103215800 LOC103215800 TNFRSF1A TNFRSF1A SIRPG SIRPG SIRPA SIRPA TNFRSF11B TNFRSF11B TGFBR1 TGFBR1 PIK3CB PIK3CB TREM2 TREM2 MITF MITF CSF1R CSF1R FOS FOS STAT1 STAT1 CALCR CALCR NCF2 NCF2 PIK3CA PIK3CA MAP2K1 MAP2K1 MAPK1 MAPK1 PPP3R1 PPP3R1 CAMK4 CAMK4 IKBKB IKBKB NFATC2 NFATC2 NFKBIA NFKBIA FYN FYN PIK3R1 PIK3R1 IRF9 IRF9 TRAF2 TRAF2 IL1B IL1B IL1A IL1A IFNGR1 IFNGR1 FHL2 FHL2 IL1R1 IL1R1 TEC TEC TAB2 TAB2 MAP3K7 MAP3K7 TNFSF11 TNFSF11 CTSK CTSK LOC103247163 LOC103247163 TNFRSF11A TNFRSF11A NCF1 NCF1 NFATC1 NFATC1 TGFB1 TGFB1 PLCG2 PLCG2 RELB RELB CYBA CYBA LOC103223675 LOC103223675 FCGR2A FCGR2A OSCAR OSCAR ENSCSAP00000016141 ENSCSAP00000016141 ENSCSAP00000016143 ENSCSAP00000016143 LILRA4 LILRA4 ENSCSAP00000016163 ENSCSAP00000016163 CSF1 CSF1 JAK1 JAK1 PIK3R3 PIK3R3 PIK3CD PIK3CD IFNB1 IFNB1 JUN JUN JUND JUND JUNB JUNB SOCS1 SOCS1 SOCS3 SOCS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
PIK3R2Uncharacterized protein. (629 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
BLNKB cell linker. (453 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (338 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
SYKTyrosine-protein kinase. (635 aa)
NCF4Neutrophil cytosolic factor 4. (294 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
SQSTM1Sequestosome 1. (440 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IFNAR2Uncharacterized protein. (516 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (571 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
BTKTyrosine-protein kinase. (497 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
NOX1NADPH oxidase 1. (564 aa)
SIRPDSignal regulatory protein delta. (198 aa)
LOC103215800Uncharacterized protein. (396 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
SIRPGSignal regulatory protein gamma. (387 aa)
SIRPAUncharacterized protein. (503 aa)
TNFRSF11BTNF receptor superfamily member 11b. (428 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (260 aa)
MITFMelanocyte inducing transcription factor. (520 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (488 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (614 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
NFATC2Nuclear factor of activated T cells 2. (928 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IRF9Interferon regulatory factor 9. (392 aa)
TRAF2TNF receptor-associated factor. (449 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (224 aa)
IFNGR1Interferon gamma receptor 1. (491 aa)
FHL2Four and a half LIM domains 2. (279 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
TECTyrosine-protein kinase. (630 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
LOC103247163Uncharacterized protein. (357 aa)
TNFRSF11ATNF receptor superfamily member 11a. (561 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
NFATC1Nuclear factor of activated T cells 1. (929 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
RELBRELB proto-oncogene, NF-kB subunit. (440 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
LOC103223675Uncharacterized protein. (290 aa)
FCGR2AUncharacterized protein. (317 aa)
OSCAROsteoclast associated Ig-like receptor. (282 aa)
ENSCSAP00000016141Uncharacterized protein. (457 aa)
ENSCSAP00000016143Uncharacterized protein. (357 aa)
LILRA4Leukocyte immunoglobulin like receptor A4. (500 aa)
ENSCSAP00000016163Ig-like domain-containing protein. (498 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (560 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IFNB1Interferon beta 1. (187 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (348 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.