STRINGSTRING
BCAR1 BCAR1 AKT2 AKT2 ITGB3 ITGB3 PAK1 PAK1 PAK4 PAK4 EGF EGF PPP1R12A PPP1R12A ACTN4 ACTN4 PRKCA PRKCA RAP1B RAP1B SPP1 SPP1 IBSP IBSP MAPK10 MAPK10 ILK ILK DOCK1 DOCK1 PARVA PARVA GRB2 GRB2 PDGFRA PDGFRA KDR KDR ITGA3 ITGA3 COL1A1 COL1A1 COMP COMP ITGA7 ITGA7 PIK3R2 PIK3R2 ITGA5 ITGA5 CHAD CHAD PARVG PARVG ITGB7 ITGB7 MYLK3 MYLK3 MYLPF MYLPF COL6A3 COL6A3 MAPK3 MAPK3 COL2A1 COL2A1 PDGFB PDGFB PRKCB PRKCB FLNA FLNA PTEN PTEN VEGFB VEGFB GSK3B GSK3B COL4A3 COL4A3 BAD BAD MYLK4 MYLK4 ZYX ZYX COL6A2 COL6A2 COL6A1 COL6A1 THBS1 THBS1 ROCK2 ROCK2 SHC3 SHC3 VTN VTN PAK6 PAK6 COL4A4 COL4A4 RAC2 RAC2 MYLK MYLK ITGB5 ITGB5 FLT4 FLT4 BRAF BRAF MAPK9 MAPK9 PIP5K1B PIP5K1B PPP1CA PPP1CA PAK3 PAK3 COL4A5 COL4A5 COL4A6 COL4A6 VCL VCL VAV1 VAV1 CCND1 CCND1 AKT3 AKT3 RAF1 RAF1 AKT1 AKT1 FLNC FLNC MYL9 MYL9 MAPK8 MAPK8 ENSCSAP00000006425 ENSCSAP00000006425 COL6A5 COL6A5 COL6A6 COL6A6 TLN1 TLN1 SHC4 SHC4 PPP1CB PPP1CB VWF VWF CAV3 CAV3 MET MET CAV1 CAV1 CAV2 CAV2 HRAS HRAS PIP5K1C PIP5K1C PIK3CB PIK3CB CCND2 CCND2 LAMB4 LAMB4 LAMB1 LAMB1 CCND3 CCND3 ITGB1 ITGB1 RELN RELN PDGFRB PDGFRB TNN TNN HGF HGF TNR TNR VEGFA VEGFA PGF PGF FLNB FLNB TLN2 TLN2 SOS1 SOS1 DIAPH1 DIAPH1 ITGAV ITGAV LAMC1 LAMC1 LAMC2 LAMC2 MYLK2 MYLK2 COL1A2 COL1A2 ITGA8 ITGA8 ITGA4 ITGA4 PIK3CA PIK3CA TNC TNC SHC2 SHC2 ACTN1 ACTN1 MAP2K1 MAP2K1 CRKL CRKL ITGA11 ITGA11 ITGB8 ITGB8 ELK1 ELK1 PAK5 PAK5 COL9A1 COL9A1 MAPK1 MAPK1 SRC SRC CRK CRK ITGA9 ITGA9 ITGA6 ITGA6 LAMC3 LAMC3 RAPGEF1 RAPGEF1 VEGFD VEGFD RASGRF1 RASGRF1 RHOA RHOA LAMB2 LAMB2 THBS4 THBS4 SOS2 SOS2 LAMB3 LAMB3 MYL5 MYL5 VAV2 VAV2 MYL7 MYL7 FYN FYN LAMA4 LAMA4 ARHGAP5 ARHGAP5 ITGB6 ITGB6 LAMA5 LAMA5 PIK3R1 PIK3R1 EGFR EGFR COL9A3 COL9A3 CAPN2 CAPN2 LAMA2 LAMA2 ITGA2 ITGA2 ITGA1 ITGA1 CTNNB1 CTNNB1 IGF1R IGF1R COL4A2 COL4A2 COL4A1 COL4A1 PDGFA PDGFA LAMA1 LAMA1 MYL12B MYL12B MYL12A MYL12A ROCK1 ROCK1 LAMA3 LAMA3 FLT1 FLT1 MYL10 MYL10 BCL2 BCL2 PDPK1 PDPK1 XIAP XIAP ITGA2B ITGA2B IGF1 IGF1 PDGFC PDGFC VASP VASP PDGFD PDGFD VEGFC VEGFC ARHGAP35 ARHGAP35 ERBB2 ERBB2 PPP1CC PPP1CC MYL2 MYL2 PXN PXN RAC3 RAC3 THBS3 THBS3 PRKCG PRKCG PIP5K1A PIP5K1A ITGA10 ITGA10 PPP1R12C PPP1R12C RAP1A RAP1A VAV3 VAV3 PIK3R3 PIK3R3 COL9A2 COL9A2 CDC42 CDC42 PIK3CD PIK3CD JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCAR1BCAR1 scaffold protein, Cas family member. (870 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PAK4Non-specific serine/threonine protein kinase. (633 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (942 aa)
ACTN4Actinin alpha 4. (911 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
RAP1BUncharacterized protein. (184 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
IBSPIntegrin binding sialoprotein. (318 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
ILKIntegrin linked kinase. (452 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1330 aa)
PARVAParvin alpha. (372 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1049 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (828 aa)
PIK3R2Uncharacterized protein. (629 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
CHADChondroadherin. (440 aa)
PARVGParvin gamma. (331 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
MYLK3Myosin light chain kinase 3. (874 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (169 aa)
COL6A3Collagen type VI alpha 3 chain. (3175 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
COL2A1Collagen type II alpha 1 chain. (1488 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
FLNAFilamin A. (2639 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
BADBCL2 associated agonist of cell death. (167 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (443 aa)
ZYXZyxin. (419 aa)
COL6A2Collagen type VI alpha 2 chain. (1019 aa)
COL6A1Uncharacterized protein. (1003 aa)
THBS1Thrombospondin 1. (1170 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
SHC3SHC adaptor protein 3. (598 aa)
VTNSMB domain-containing protein. (478 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
RAC2Rac family small GTPase 2. (192 aa)
MYLKMyosin light chain kinase. (1914 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (502 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
COL4A5Collagen type IV alpha 5 chain. (882 aa)
COL4A6Collagen IV NC1 domain-containing protein. (1379 aa)
VCLVinculin. (1134 aa)
VAV1Vav guanine nucleotide exchange factor 1. (719 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FLNCFilamin C. (2725 aa)
MYL9Myosin light chain 9. (172 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ENSCSAP00000006425Uncharacterized protein. (2238 aa)
COL6A5Collagen type VI alpha 5 chain. (2618 aa)
COL6A6Collagen type VI alpha 6 chain. (2262 aa)
TLN1Talin 1. (2558 aa)
SHC4SHC adaptor protein 4. (630 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
VWFVon Willebrand factor. (2813 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (668 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
LAMB4Laminin subunit beta 4. (1762 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
RELNReelin. (3427 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TNNTenascin N. (1299 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
TNRTenascin R. (1034 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
FLNBFilamin B. (2602 aa)
TLN2Talin 2. (2542 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
DIAPH1Diaphanous related formin 1. (1243 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
LAMC1Laminin subunit gamma 1. (1573 aa)
LAMC2Laminin subunit gamma 2. (1193 aa)
MYLK2Myosin light chain kinase 2. (595 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TNCTenascin C. (2201 aa)
SHC2Uncharacterized protein. (590 aa)
ACTN1Actinin alpha 1. (914 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
ELK1Uncharacterized protein. (296 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SRCTyrosine-protein kinase. (633 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (934 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1073 aa)
LAMC3Uncharacterized protein. (820 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1264 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1257 aa)
RHOARas homolog family member A. (193 aa)
LAMB2Laminin subunit beta 2. (1798 aa)
THBS4Thrombospondin 4. (870 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
MYL5Myosin light chain 5. (173 aa)
VAV2Vav guanine nucleotide exchange factor 2. (896 aa)
MYL7Myosin light chain 7. (175 aa)
FYNTyrosine-protein kinase. (537 aa)
LAMA4Laminin subunit alpha 4. (1816 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
COL9A3Uncharacterized protein. (684 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
LAMA2Laminin subunit alpha 2. (3147 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
CTNNB1Catenin beta 1. (781 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
COL4A2Collagen type IV alpha 2 chain. (1696 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
LAMA1Uncharacterized protein. (1845 aa)
MYL12BMyosin light chain 12B. (172 aa)
MYL12AMyosin light chain 12A. (171 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
MYL10Myosin light chain 10. (136 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
XIAPRING-type domain-containing protein. (497 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
IGF1Insulin like growth factor 1. (159 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
PDGFDPlatelet derived growth factor D. (332 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
MYL2Myosin light chain 2. (166 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (591 aa)
RAC3Rac family small GTPase 3. (192 aa)
THBS3Thrombospondin 3. (947 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (425 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (786 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
VAV3Vav guanine nucleotide exchange factor 3. (782 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
CDC42Cell division cycle 42. (191 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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