STRINGSTRING
IL2 IL2 AKT2 AKT2 PAK1 PAK1 NFKB1 NFKB1 NFATC3 NFATC3 PPP3CA PPP3CA MDM2 MDM2 MAPK10 MAPK10 RRAS2 RRAS2 CCL17 CCL17 CCL22 CCL22 MAPK11 MAPK11 STAT2 STAT2 IL23A IL23A CYLD CYLD PIK3R2 PIK3R2 NFKB2 NFKB2 CHUK CHUK PYCARD PYCARD MAPK3 MAPK3 CBLB CBLB IKBKG IKBKG SYK SYK EGR2 EGR2 KSR1 KSR1 ITPR2 ITPR2 KRAS KRAS RELA RELA MAPK9 MAPK9 CD209 CD209 PPP3CB PPP3CB NLRP3 NLRP3 CLEC1B CLEC1B AKT3 AKT3 RAF1 RAF1 ITPR3 ITPR3 CLEC4E CLEC4E AKT1 AKT1 LSP1 LSP1 MAPK8 MAPK8 MAPK14 MAPK14 MAPK13 MAPK13 IL12B IL12B CASP8 CASP8 ITPR1 ITPR1 MRAS MRAS HRAS HRAS PIK3CB PIK3CB CALM1 CALM1 STAT1 STAT1 IL12A IL12A PIK3CA PIK3CA PRKCD PRKCD PTGS2 PTGS2 CALML4 CALML4 MAPK1 MAPK1 SRC SRC IRF1 IRF1 IL6 IL6 PPP3R1 PPP3R1 IKBKE IKBKE MAPKAPK2 MAPKAPK2 IL10 IL10 IKBKB IKBKB RHOA RHOA NFATC2 NFATC2 NFKBIA NFKBIA CARD9 CARD9 NFATC4 NFATC4 PIK3R1 PIK3R1 IRF9 IRF9 EGR3 EGR3 IL1B IL1B IL17D IL17D MALT1 MALT1 NFATC1 NFATC1 PLCG2 PLCG2 BCL3 BCL3 RELB RELB CASP1 CASP1 ENSCSAP00000014978 ENSCSAP00000014978 FCER1G FCER1G RRAS RRAS PTPN11 PTPN11 ARHGEF12 ARHGEF12 NRAS NRAS BCL10 BCL10 PIK3R3 PIK3R3 PLK3 PLK3 PIK3CD PIK3CD JUN JUN CALML5 CALML5 CALML3 CALML3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
NFATC3RHD domain-containing protein. (637 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
RRAS2RAS related 2. (204 aa)
CCL17C-C motif chemokine. (91 aa)
CCL22C-C motif chemokine ligand 22. (93 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
PIK3R2Uncharacterized protein. (629 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PYCARDPYD and CARD domain containing. (195 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CBLBCbl proto-oncogene B. (982 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
SYKTyrosine-protein kinase. (635 aa)
EGR2Early growth response 2. (476 aa)
KSR1Kinase suppressor of ras 1. (851 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
CD209CD209 molecule. (360 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
CLEC1BC-type lectin domain family 1 member B. (229 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LSP1Lymphocyte specific protein 1. (339 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (341 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (496 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (572 aa)
CALML4Calmodulin like 4. (194 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SRCTyrosine-protein kinase. (633 aa)
IRF1Interferon regulatory factor. (325 aa)
IL6Interleukin 6. (212 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
IL10Interleukin 10. (178 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RHOARas homolog family member A. (193 aa)
NFATC2Nuclear factor of activated T cells 2. (928 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CARD9Caspase recruitment domain family member 9. (499 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IRF9Interferon regulatory factor 9. (392 aa)
EGR3Early growth response 3. (387 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
IL17DInterleukin 17D. (202 aa)
MALT1MALT1 paracaspase. (729 aa)
NFATC1Nuclear factor of activated T cells 1. (929 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BCL3BCL3 transcription coactivator. (358 aa)
RELBRELB proto-oncogene, NF-kB subunit. (440 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (462 aa)
ENSCSAP00000014978Uncharacterized protein; Belongs to the peptidase C14A family. (392 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
RRASRAS related. (218 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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