STRINGSTRING
PAK1 PAK1 ICAM2 ICAM2 PPP3CA PPP3CA PRKCA PRKCA TYROBP TYROBP IFNG IFNG GRB2 GRB2 PIK3R2 PIK3R2 MAPK3 MAPK3 LAT LAT PRKCB PRKCB SYK SYK SHC3 SHC3 ICAM1 ICAM1 ITGB2 ITGB2 RAC2 RAC2 KRAS KRAS BRAF BRAF PRF1 PRF1 PPP3CB PPP3CB KLRC1 KLRC1 ENSCSAP00000005199 ENSCSAP00000005199 KLRK1 KLRK1 ENSCSAP00000005254 ENSCSAP00000005254 ENSCSAP00000005267 ENSCSAP00000005267 KLRD1 KLRD1 ENSCSAP00000005329 ENSCSAP00000005329 ENSCSAP00000005377 ENSCSAP00000005377 ENSCSAP00000005390 ENSCSAP00000005390 LOC103229850 LOC103229850 VAV1 VAV1 ENSCSAP00000005509 ENSCSAP00000005509 RAF1 RAF1 IFNA2 IFNA2 IFNA8 IFNA8 IFNAR2 IFNAR2 IFNAR1 IFNAR1 IFNGR2 IFNGR2 LCP2 LCP2 PTPN6 PTPN6 SHC4 SHC4 MAP2K2 MAP2K2 CD247 CD247 HRAS HRAS PIK3CB PIK3CB FASLG FASLG SOS1 SOS1 TNFSF10 TNFSF10 PIK3CA PIK3CA SHC2 SHC2 MAP2K1 MAP2K1 ARAF ARAF MAPK1 MAPK1 CSF2 CSF2 PLCG1 PLCG1 ULBP3 ULBP3 PPP3R1 PPP3R1 SOS2 SOS2 NFATC2 NFATC2 VAV2 VAV2 FYN FYN SH3BP2 SH3BP2 GZMB GZMB PIK3R1 PIK3R1 PTK2B PTK2B TNFRSF10A TNFRSF10A IFNGR1 IFNGR1 RAET1E RAET1E ENSCSAP00000013292 ENSCSAP00000013292 ULBP1 ULBP1 ENSCSAP00000013296 ENSCSAP00000013296 ZAP70 ZAP70 NFATC1 NFATC1 SH2D1A SH2D1A PLCG2 PLCG2 CASP3 CASP3 SH2D1B SH2D1B LOC103223675 LOC103223675 FCER1G FCER1G CD244 CD244 CD48 CD48 PTPN11 PTPN11 RAC3 RAC3 PRKCG PRKCG ENSCSAP00000016233 ENSCSAP00000016233 KIR2DL4 KIR2DL4 ENSCSAP00000016243 ENSCSAP00000016243 NCR1 NCR1 NRAS NRAS VAV3 VAV3 PIK3R3 PIK3R3 PIK3CD PIK3CD ENSCSAP00000017563 ENSCSAP00000017563 ENSCSAP00000017564 ENSCSAP00000017564 IFNA6 IFNA6 IFNA14 IFNA14 ENSCSAP00000017567 ENSCSAP00000017567 ENSCSAP00000017568 ENSCSAP00000017568 ENSCSAP00000017569 ENSCSAP00000017569 IFNB1 IFNB1 ENSCSAP00000019090 ENSCSAP00000019090
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ICAM2Intercellular adhesion molecule 2. (275 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (629 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LATLinker for activation of T cells. (235 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
SYKTyrosine-protein kinase. (635 aa)
SHC3SHC adaptor protein 3. (598 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
ITGB2Integrin beta. (784 aa)
RAC2Rac family small GTPase 2. (192 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
PRF1Perforin 1. (555 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
KLRC1Killer cell lectin like receptor C1. (233 aa)
ENSCSAP00000005199Ig-like domain-containing protein. (190 aa)
KLRK1Killer cell lectin like receptor K1. (216 aa)
ENSCSAP00000005254Ig-like domain-containing protein. (191 aa)
ENSCSAP00000005267Ig-like domain-containing protein. (146 aa)
KLRD1Uncharacterized protein. (102 aa)
ENSCSAP00000005329Ig-like domain-containing protein. (126 aa)
ENSCSAP00000005377Ig-like domain-containing protein. (139 aa)
ENSCSAP00000005390Ig-like domain-containing protein. (189 aa)
LOC103229850Ig-like domain-containing protein. (134 aa)
VAV1Vav guanine nucleotide exchange factor 1. (719 aa)
ENSCSAP00000005509Ig-like domain-containing protein. (162 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
IFNA2Interferon alpha 2. (190 aa)
IFNA8Interferon alpha 8. (195 aa)
IFNAR2Uncharacterized protein. (516 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (571 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CD247CD247 molecule. (165 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (282 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SHC2Uncharacterized protein. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CSF2Colony stimulating factor 2. (144 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
ULBP3UL16 binding protein 3. (215 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
NFATC2Nuclear factor of activated T cells 2. (928 aa)
VAV2Vav guanine nucleotide exchange factor 2. (896 aa)
FYNTyrosine-protein kinase. (537 aa)
SH3BP2SH3 domain binding protein 2. (589 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (290 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
TNFRSF10ATNF receptor superfamily member 10a. (472 aa)
IFNGR1Interferon gamma receptor 1. (491 aa)
RAET1EMHC_I-like_Ag-recog domain-containing protein. (264 aa)
ENSCSAP00000013292MHC_I-like_Ag-recog domain-containing protein. (246 aa)
ULBP1MHC_I-like_Ag-recog domain-containing protein. (244 aa)
ENSCSAP00000013296MHC_I-like_Ag-recog domain-containing protein. (246 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFATC1Nuclear factor of activated T cells 1. (929 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
SH2D1BSH2 domain containing 1B. (132 aa)
LOC103223675Uncharacterized protein. (290 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
CD244CD244 molecule. (249 aa)
CD48CD48 molecule. (208 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
RAC3Rac family small GTPase 3. (192 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ENSCSAP00000016233Uncharacterized protein. (444 aa)
KIR2DL4Uncharacterized protein. (443 aa)
ENSCSAP00000016243Ig domain-containing protein. (204 aa)
NCR1Natural cytotoxicity triggering receptor 1. (304 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
VAV3Vav guanine nucleotide exchange factor 3. (782 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ENSCSAP00000017563Uncharacterized protein. (189 aa)
ENSCSAP00000017564Uncharacterized protein. (189 aa)
IFNA6Interferon alpha 6. (189 aa)
IFNA14Interferon alpha 14. (189 aa)
ENSCSAP00000017567Uncharacterized protein. (189 aa)
ENSCSAP00000017568Uncharacterized protein. (189 aa)
ENSCSAP00000017569Uncharacterized protein. (189 aa)
IFNB1Interferon beta 1. (187 aa)
ENSCSAP00000019090Ig-like domain-containing protein. (103 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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