STRINGSTRING
IL2 IL2 DLL3 DLL3 NFKBIB NFKBIB NFKB1 NFKB1 NFATC3 NFATC3 PPP3CA PPP3CA IFNG IFNG MAPK10 MAPK10 MAPK11 MAPK11 STAT6 STAT6 IL12RB1 IL12RB1 JAK3 JAK3 CHUK CHUK NOTCH3 NOTCH3 MAPK3 MAPK3 LAT LAT IL4R IL4R IKBKG IKBKG IL2RB IL2RB DLL4 DLL4 ENSCSAP00000004095 ENSCSAP00000004095 RELA RELA MAPK9 MAPK9 MAML1 MAML1 PPP3CB PPP3CB JAK2 JAK2 HLA-DRA HLA-DRA HLA-DRB5 HLA-DRB5 HLA-DQA1 HLA-DQA1 HLA-DQB1 HLA-DQB1 HLA-DOB HLA-DOB MHC-DMB MHC-DMB HLA-DMA HLA-DMA HLA-DOA HLA-DOA MHC-DPA1 MHC-DPA1 MHC-DPB1 MHC-DPB1 JAG2 JAG2 IFNGR2 IFNGR2 MAPK8 MAPK8 MAPK14 MAPK14 MAPK13 MAPK13 CD4 CD4 IL12B IL12B CD247 CD247 IL2RG IL2RG DLL1 DLL1 STAT4 STAT4 FOS FOS STAT1 STAT1 IL12A IL12A NFKBIE NFKBIE GATA3 GATA3 PRKCQ PRKCQ IL2RA IL2RA MAPK1 MAPK1 JAG1 JAG1 IL4 IL4 IL13 IL13 IL5 IL5 PLCG1 PLCG1 PPP3R1 PPP3R1 IKBKB IKBKB NFATC2 NFATC2 NFKBIA NFKBIA NOTCH1 NOTCH1 RBPJ RBPJ IFNGR1 IFNGR1 ZAP70 ZAP70 NFATC1 NFATC1 LOC103247136 LOC103247136 ENSCSAP00000014311 ENSCSAP00000014311 ENSCSAP00000014315 ENSCSAP00000014315 MAML3 MAML3 MAML2 MAML2 STAT5A STAT5A STAT5B STAT5B CD3E CD3E CD3D CD3D CD3G CD3G TBX21 TBX21 NOTCH2 NOTCH2 JAK1 JAK1 RUNX3 RUNX3 JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
DLL3Delta like canonical Notch ligand 3. (614 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
NFATC3RHD domain-containing protein. (637 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (662 aa)
JAK3Tyrosine-protein kinase. (1069 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
NOTCH3Notch receptor 3. (1980 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
LATLinker for activation of T cells. (235 aa)
IL4RInterleukin 4 receptor. (825 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
ENSCSAP00000004095Ig-like domain-containing protein. (166 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
MAML1Mastermind like transcriptional coactivator 1. (790 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
HLA-DRB5Ig-like domain-containing protein. (266 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (261 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (248 aa)
MHC-DMBIg-like domain-containing protein. (263 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (260 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
MHC-DPA1Ig-like domain-containing protein; Belongs to the MHC class II family. (260 aa)
MHC-DPB1Ig-like domain-containing protein. (256 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CD4CD4 molecule. (560 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (341 aa)
CD247CD247 molecule. (165 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
STAT4Signal transducer and activator of transcription. (750 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
GATA3GATA binding protein 3. (443 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (745 aa)
IL2RAInterleukin 2 receptor subunit alpha. (274 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
IL13Interleukin 13. (146 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
NFATC2Nuclear factor of activated T cells 2. (928 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
NOTCH1Notch receptor 1. (2555 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (357 aa)
IFNGR1Interferon gamma receptor 1. (491 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFATC1Nuclear factor of activated T cells 1. (929 aa)
LOC103247136Ig-like domain-containing protein; Belongs to the MHC class II family. (260 aa)
ENSCSAP00000014311Ig-like domain-containing protein. (252 aa)
ENSCSAP00000014315Ig-like domain-containing protein. (236 aa)
MAML3Mastermind like transcriptional coactivator 3. (982 aa)
MAML2Mastermind like transcriptional coactivator 2. (923 aa)
STAT5ASignal transducer and activator of transcription. (798 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
CD3ECD3e molecule. (197 aa)
CD3DCD3d molecule. (171 aa)
CD3GCD3g molecule. (209 aa)
TBX21T-box transcription factor 21. (535 aa)
NOTCH2Notch receptor 2. (2471 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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