STRINGSTRING
IL2 IL2 AKT2 AKT2 PAK1 PAK1 PAK4 PAK4 NFKBIB NFKBIB NFKB1 NFKB1 NFATC3 NFATC3 PPP3CA PPP3CA IFNG IFNG MAPK10 MAPK10 CDK4 CDK4 GRB2 GRB2 MAPK11 MAPK11 PIK3R2 PIK3R2 CHUK CHUK GRAP2 GRAP2 MAPK3 MAPK3 CBLB CBLB LAT LAT IKBKG IKBKG GSK3B GSK3B RASGRP1 RASGRP1 PAK6 PAK6 CD40LG CD40LG KRAS KRAS ENSCSAP00000004095 ENSCSAP00000004095 RELA RELA MAP2K7 MAP2K7 MAPK9 MAPK9 DLG1 DLG1 PPP3CB PPP3CB PAK3 PAK3 VAV1 VAV1 AKT3 AKT3 RAF1 RAF1 AKT1 AKT1 LCP2 LCP2 MAPK8 MAPK8 PTPN6 PTPN6 MAPK14 MAPK14 MAPK13 MAPK13 CD4 CD4 ICOS ICOS CTLA4 CTLA4 CD28 CD28 ITK ITK MAP2K2 MAP2K2 NCK1 NCK1 CD247 CD247 HRAS HRAS PIK3CB PIK3CB FOS FOS SOS1 SOS1 NFKBIE NFKBIE PIK3CA PIK3CA MAP2K1 MAP2K1 PRKCQ PRKCQ PAK5 PAK5 MAPK1 MAPK1 PTPRC PTPRC IL4 IL4 IL5 IL5 CSF2 CSF2 PLCG1 PLCG1 PPP3R1 PPP3R1 IL10 IL10 IKBKB IKBKB RHOA RHOA SOS2 SOS2 NFATC2 NFATC2 NFKBIA NFKBIA VAV2 VAV2 FYN FYN PIK3R1 PIK3R1 CD8A CD8A CD8B CD8B NCK2 NCK2 TEC TEC MAP3K7 MAP3K7 ZAP70 ZAP70 MAP3K8 MAP3K8 MALT1 MALT1 NFATC1 NFATC1 PDPK1 PDPK1 CD3E CD3E CD3D CD3D CD3G CD3G NRAS NRAS VAV3 VAV3 BCL10 BCL10 PIK3R3 PIK3R3 CDC42 CDC42 PIK3CD PIK3CD JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PAK4Non-specific serine/threonine protein kinase. (633 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
NFATC3RHD domain-containing protein. (637 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIK3R2Uncharacterized protein. (629 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CBLBCbl proto-oncogene B. (982 aa)
LATLinker for activation of T cells. (235 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
RASGRP1RAS guanyl releasing protein 1. (659 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSCSAP00000004095Ig-like domain-containing protein. (166 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
DLG1Uncharacterized protein; Belongs to the MAGUK family. (800 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
VAV1Vav guanine nucleotide exchange factor 1. (719 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CD4CD4 molecule. (560 aa)
ICOSInducible T cell costimulator. (192 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (199 aa)
CD28CD28 molecule. (220 aa)
ITKTyrosine-protein kinase. (620 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
NCK1Cytoplasmic protein. (377 aa)
CD247CD247 molecule. (165 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (745 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1309 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
CSF2Colony stimulating factor 2. (144 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
IL10Interleukin 10. (178 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RHOARas homolog family member A. (193 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
NFATC2Nuclear factor of activated T cells 2. (928 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
VAV2Vav guanine nucleotide exchange factor 2. (896 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CD8ACD8a molecule. (276 aa)
CD8BIg-like domain-containing protein. (210 aa)
NCK2Cytoplasmic protein. (382 aa)
TECTyrosine-protein kinase. (630 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
MALT1MALT1 paracaspase. (729 aa)
NFATC1Nuclear factor of activated T cells 1. (929 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
CD3ECD3e molecule. (197 aa)
CD3DCD3d molecule. (171 aa)
CD3GCD3g molecule. (209 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
VAV3Vav guanine nucleotide exchange factor 3. (782 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
CDC42Cell division cycle 42. (191 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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