STRINGSTRING
AKT2 AKT2 MAP3K3 MAP3K3 NFKBIB NFKBIB NFKB1 NFKB1 FRS2 FRS2 RAP1B RAP1B MAPK10 MAPK10 IRAK3 IRAK3 GRB2 GRB2 MAPK11 MAPK11 PIK3R2 PIK3R2 TRAF6 TRAF6 MAPK3 MAPK3 SH2B1 SH2B1 ATF4 ATF4 IRAK4 IRAK4 IRAK1 IRAK1 KIDINS220 KIDINS220 GSK3B GSK3B BAD BAD SHC3 SHC3 NTRK2 NTRK2 KRAS KRAS MAPK7 MAPK7 RELA RELA MAP2K7 MAP2K7 BRAF BRAF MAPK9 MAPK9 ARHGDIB ARHGDIB CAMK2G CAMK2G AKT3 AKT3 BEX3 BEX3 RAF1 RAF1 AKT1 AKT1 MAPK8 MAPK8 MAPK14 MAPK14 MAPK13 MAPK13 SHC4 SHC4 RPS6KA6 RPS6KA6 MAP2K2 MAP2K2 MATK MATK NTF3 NTF3 HRAS HRAS PIK3CB PIK3CB TP53 TP53 RPS6KA5 RPS6KA5 CALM1 CALM1 CAMK2A CAMK2A FASLG FASLG RPS6KA2 RPS6KA2 SOS1 SOS1 NFKBIE NFKBIE MAGED1 MAGED1 PSEN1 PSEN1 RIPK2 RIPK2 PIK3CA PIK3CA PRKCD PRKCD SHC2 SHC2 MAP2K1 MAP2K1 CRKL CRKL MAP2K5 MAP2K5 CALML4 CALML4 MAPK1 MAPK1 PLCG1 PLCG1 CRK CRK YWHAE YWHAE RPS6KA3 RPS6KA3 ABL1 ABL1 RAPGEF1 RAPGEF1 MAPKAPK2 MAPKAPK2 CAMK4 CAMK4 IKBKB IKBKB RHOA RHOA FOXO3 FOXO3 SOS2 SOS2 NFKBIA NFKBIA CAMK2B CAMK2B PIK3R1 PIK3R1 MAP3K1 MAP3K1 PSEN2 PSEN2 MAP3K5 MAP3K5 NTRK3 NTRK3 SH2B2 SH2B2 BCL2 BCL2 PDPK1 PDPK1 GAB1 GAB1 PLCG2 PLCG2 PRDM4 PRDM4 BAX BAX SH2B3 SH2B3 PTPN11 PTPN11 NGFR NGFR NTRK1 NTRK1 NRAS NRAS ZNF274 ZNF274 RAP1A RAP1A SORT1 SORT1 PIK3R3 PIK3R3 RPS6KA1 RPS6KA1 CDC42 CDC42 PIK3CD PIK3CD TP73 TP73 NGF NGF JUN JUN CALML5 CALML5 CALML3 CALML3 BDNF BDNF NTF4 NTF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
RAP1BUncharacterized protein. (184 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PIK3R2Uncharacterized protein. (629 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SH2B1SH2B adaptor protein 1. (671 aa)
ATF4Activating transcription factor 4. (351 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (686 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
BADBCL2 associated agonist of cell death. (167 aa)
SHC3SHC adaptor protein 3. (598 aa)
NTRK2Neurotrophic receptor tyrosine kinase 2. (477 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (201 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (588 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
BEX3Brain expressed X-linked 3. (111 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
SHC4SHC adaptor protein 4. (630 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MATKTyrosine-protein kinase. (485 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
RPS6KA5Ribosomal protein S6 kinase. (776 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (282 aa)
RPS6KA2Ribosomal protein S6 kinase. (730 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
NFKBIENFKB inhibitor epsilon. (361 aa)
MAGED1MAGE family member D1. (778 aa)
PSEN1Presenilin 1. (467 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (443 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
SHC2Uncharacterized protein. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
CALML4Calmodulin like 4. (194 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (240 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1264 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (614 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RHOARas homolog family member A. (193 aa)
FOXO3Forkhead box O3. (672 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (628 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1345 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1219 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
SH2B2SH2B adaptor protein 2. (522 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
SH2B3SH2B adaptor protein 3. (570 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
NGFRNerve growth factor receptor. (427 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ZNF274Uncharacterized protein. (263 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
SORT1Sortilin. (831 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
RPS6KA1Ribosomal protein S6 kinase. (735 aa)
CDC42Cell division cycle 42. (191 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (637 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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