STRINGSTRING
PRKCA PRKCA KCNMB4 KCNMB4 ABCC8 ABCC8 ADCY7 ADCY7 RAB3A RAB3A CREB3L1 CREB3L1 ADCY6 ADCY6 ATF4 ATF4 PRKCB PRKCB PLCB3 PLCB3 PLCB2 PLCB2 ADCY5 ADCY5 GNAQ GNAQ ADCY3 ADCY3 CREB3L2 CREB3L2 CAMK2G CAMK2G ATF6B ATF6B ADCY9 ADCY9 ITPR3 ITPR3 RYR2 RYR2 INS INS KCNMB1 KCNMB1 ADCY8 ADCY8 CREB1 CREB1 CREB3 CREB3 CREB3L3 CREB3L3 GLP1R GLP1R ATP1B1 ATP1B1 GNA11 GNA11 ATP1B3 ATP1B3 CACNA1C CACNA1C ATP1B2 ATP1B2 CAMK2A CAMK2A PCLO PCLO SLC2A2 SLC2A2 CACNA1F CACNA1F KCNMB2 KCNMB2 KCNMB3 KCNMB3 CACNA1D CACNA1D PLCB1 PLCB1 PLCB4 PLCB4 SNAP25 SNAP25 CACNA1S CACNA1S CREB5 CREB5 ATF2 ATF2 RAPGEF4 RAPGEF4 ADCYAP1R1 ADCYAP1R1 KCNN2 KCNN2 GNAS GNAS GCK GCK CAMK2B CAMK2B GCG GCG KCNU1 KCNU1 ADCY1 ADCY1 ADCY4 ADCY4 CCKAR CCKAR CCK CCK ADCY2 ADCY2 PDX1 PDX1 STX1A STX1A ATP1B4 ATP1B4 ATP1A3 ATP1A3 KCNN4 KCNN4 TRPM4 TRPM4 FXYD2 FXYD2 ATP1A4 ATP1A4 ATP1A2 ATP1A2 GIP GIP KCNN3 KCNN3 PRKCG PRKCG ATP1A1 ATP1A1 PRKACB PRKACB SLC2A1 SLC2A1 GPR119 GPR119 PRKACG PRKACG FFAR1 FFAR1 LOC103243499 LOC103243499 ENSCSAP00000018403 ENSCSAP00000018403 KCNJ11 KCNJ11 CHRM3 CHRM3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
ABCC8ATP binding cassette subfamily C member 8. (1581 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATF4Activating transcription factor 4. (351 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
GNAQG protein subunit alpha q. (301 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (588 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
RYR2Ryanodine receptor 2. (4906 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (311 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (464 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
GNA11G protein subunit alpha 11. (394 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (265 aa)
CACNA1CCalcium voltage-gated channel subunit alpha1 C. (1898 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
PCLOPiccolo presynaptic cytomatrix protein. (4029 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
CACNA1FIon_trans domain-containing protein. (233 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (286 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2036 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (501 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (496 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (846 aa)
GNASUncharacterized protein. (335 aa)
GCKPhosphotransferase. (466 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (628 aa)
GCGGlucagon. (180 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1023 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
CCKARCholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
CCKCholecystokinin. (114 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1013 aa)
KCNN4CaMBD domain-containing protein. (167 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1214 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
GIPGastric inhibitory polypeptide. (153 aa)
KCNN3Potassium calcium-activated channel subfamily N member 3. (726 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (416 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
LOC103243499Uncharacterized protein. (251 aa)
ENSCSAP00000018403V-SNARE coiled-coil homology domain-containing protein. (116 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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