STRINGSTRING
AKT2 AKT2 GRB2 GRB2 GNAO1 GNAO1 MMP2 MMP2 ADCY7 ADCY7 PIK3R2 PIK3R2 SP1 SP1 KRT18 KRT18 CREB3L1 CREB3L1 MAPK3 MAPK3 ADCY6 ADCY6 ATF4 ATF4 NOS3 NOS3 PLCB3 PLCB3 SHC3 SHC3 PLCB2 PLCB2 ADCY5 ADCY5 ITPR2 ITPR2 GNAQ GNAQ KRAS KRAS GABBR1 GABBR1 TFF1 TFF1 KCNJ6 KCNJ6 NCOA1 NCOA1 ADCY3 ADCY3 POMC POMC CREB3L2 CREB3L2 ATF6B ATF6B AKT3 AKT3 RAF1 RAF1 ADCY9 ADCY9 ITPR3 ITPR3 AKT1 AKT1 CTSD CTSD FKBP5 FKBP5 ADCY8 ADCY8 CREB1 CREB1 HSP90AA1 HSP90AA1 SHC4 SHC4 CREB3 CREB3 CREB3L3 CREB3L3 MAP2K2 MAP2K2 ITPR1 ITPR1 GABBR2 GABBR2 HRAS HRAS PIK3CB PIK3CB FKBP4 FKBP4 EBAG9 EBAG9 CALM1 CALM1 GNAI1 GNAI1 FOS FOS SOS1 SOS1 HSP90AB1 HSP90AB1 HBEGF HBEGF PIK3CA PIK3CA PRKCD PRKCD SHC2 SHC2 MAP2K1 MAP2K1 CALML4 CALML4 OPRM1 OPRM1 PLCB1 PLCB1 PLCB4 PLCB4 MAPK1 MAPK1 SRC SRC ESR2 ESR2 NCOA2 NCOA2 ESR1 ESR1 GNAI2 GNAI2 CREB5 CREB5 ATF2 ATF2 MMP9 MMP9 NCOA3 NCOA3 TGFA TGFA SOS2 SOS2 GNAS GNAS ADCY1 ADCY1 ADCY4 ADCY4 PIK3R1 PIK3R1 KCNJ3 KCNJ3 EGFR EGFR GRM1 GRM1 ADCY2 ADCY2 BCL2 BCL2 PGR PGR HSP90B1 HSP90B1 KRT17 KRT17 KRT16 KRT16 KRT14 KRT14 KRT9 KRT9 KRT19 KRT19 KRT15 KRT15 KRT13 KRT13 KRT36 KRT36 KRT35 KRT35 KRT32 KRT32 KRT38 KRT38 ENSCSAP00000015119 ENSCSAP00000015119 KRT34 KRT34 KRT33B KRT33B KRT33A KRT33A KRT40 KRT40 KRT39 KRT39 KRT23 KRT23 KRT20 KRT20 KRT12 KRT12 KRT10 KRT10 KRT28 KRT28 KRT27 KRT27 KRT25 KRT25 KRT24 KRT24 RARA RARA KCNJ9 KCNJ9 HSPA8 HSPA8 KCNJ5 KCNJ5 NRAS NRAS GNAI3 GNAI3 PRKACB PRKACB PIK3R3 PIK3R3 PIK3CD PIK3CD JUN JUN PRKACG PRKACG LOC103243499 LOC103243499 ENSCSAP00000018438 ENSCSAP00000018438 CALML5 CALML5 CALML3 CALML3 HSPA1A HSPA1A HSPA1L HSPA1L GPER1 GPER1 HSPA2 HSPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GNAO1G protein subunit alpha o1. (354 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
PIK3R2Uncharacterized protein. (629 aa)
SP1Sp1 transcription factor. (786 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (352 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATF4Activating transcription factor 4. (351 aa)
NOS3Nitric oxide synthase 3. (867 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
SHC3SHC adaptor protein 3. (598 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
GNAQG protein subunit alpha q. (301 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
TFF1Trefoil factor 1. (84 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (331 aa)
NCOA1Nuclear receptor coactivator. (1399 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
POMCProopiomelanocortin. (265 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (412 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
HSP90AA1HATPase_c domain-containing protein. (387 aa)
SHC4SHC adaptor protein 4. (630 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (311 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GNAI1G protein subunit alpha i1. (354 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
SHC2Uncharacterized protein. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CALML4Calmodulin like 4. (194 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SRCTyrosine-protein kinase. (633 aa)
ESR2Estrogen receptor 2. (530 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
ESR1Estrogen receptor 1. (487 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (501 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
NCOA3Nuclear receptor coactivator. (1417 aa)
TGFATransforming growth factor alpha. (158 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
GNASUncharacterized protein. (335 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
GRM1G_PROTEIN_RECEP_F3_4 domain-containing protein. (878 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PGRProgesterone receptor. (935 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
KRT17Keratin 17; Belongs to the intermediate filament family. (432 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (476 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (462 aa)
KRT9Keratin 9; Belongs to the intermediate filament family. (633 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (400 aa)
KRT15Keratin 15; Belongs to the intermediate filament family. (456 aa)
KRT13IF rod domain-containing protein; Belongs to the intermediate filament family. (189 aa)
KRT36Keratin 36; Belongs to the intermediate filament family. (421 aa)
KRT35Keratin 35; Belongs to the intermediate filament family. (455 aa)
KRT32Keratin 32; Belongs to the intermediate filament family. (448 aa)
KRT38Keratin 38; Belongs to the intermediate filament family. (452 aa)
ENSCSAP00000015119IF rod domain-containing protein; Belongs to the intermediate filament family. (416 aa)
KRT34Keratin 34; Belongs to the intermediate filament family. (436 aa)
KRT33BKeratin 33B; Belongs to the intermediate filament family. (404 aa)
KRT33AKeratin 33A; Belongs to the intermediate filament family. (404 aa)
KRT40Keratin 40; Belongs to the intermediate filament family. (431 aa)
KRT39Keratin 39; Belongs to the intermediate filament family. (491 aa)
KRT23Keratin 23; Belongs to the intermediate filament family. (422 aa)
KRT20Keratin 20; Belongs to the intermediate filament family. (424 aa)
KRT12Keratin 12; Belongs to the intermediate filament family. (495 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (616 aa)
KRT28Keratin 28; Belongs to the intermediate filament family. (464 aa)
KRT27Keratin 27; Belongs to the intermediate filament family. (449 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (460 aa)
KRT24Keratin 24; Belongs to the intermediate filament family. (525 aa)
RARARetinoic acid receptor alpha. (462 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (450 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (432 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
LOC103243499Uncharacterized protein. (251 aa)
ENSCSAP00000018438IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
HSPA1AUncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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