STRINGSTRING
AKT2 AKT2 ARRB1 ARRB1 NFKB1 NFKB1 PRKCA PRKCA MAPK10 MAPK10 GRB2 GRB2 MAPK11 MAPK11 GNAO1 GNAO1 COL1A1 COL1A1 MMP2 MMP2 ADCY7 ADCY7 PIK3R2 PIK3R2 INSL3 INSL3 CREB3L1 CREB3L1 MAPK3 MAPK3 ADCY6 ADCY6 ATF4 ATF4 RLN3 RLN3 GNG3 GNG3 NOS3 NOS3 ACTA2 ACTA2 VEGFB VEGFB PLCB3 PLCB3 COL4A3 COL4A3 SHC3 SHC3 PLCB2 PLCB2 NOS2 NOS2 COL4A4 COL4A4 EDN1 EDN1 ADCY5 ADCY5 KRAS KRAS RELA RELA MAP2K7 MAP2K7 MAPK9 MAPK9 ADCY3 ADCY3 CREB3L2 CREB3L2 COL4A5 COL4A5 RLN2 RLN2 COL4A6 COL4A6 MAP2K4 MAP2K4 ATF6B ATF6B AKT3 AKT3 RAF1 RAF1 ADCY9 ADCY9 TGFBR2 TGFBR2 AKT1 AKT1 ADCY8 ADCY8 CREB1 CREB1 MAPK8 MAPK8 MAPK14 MAPK14 MAPK13 MAPK13 GNB3 GNB3 SHC4 SHC4 CREB3 CREB3 CREB3L3 CREB3L3 MAP2K2 MAP2K2 HRAS HRAS TGFBR1 TGFBR1 PIK3CB PIK3CB GNA15 GNA15 GNB5 GNB5 GNG7 GNG7 GNAI1 GNAI1 VEGFA VEGFA FOS FOS GNG10 GNG10 SOS1 SOS1 COL3A1 COL3A1 GNG11 GNG11 COL1A2 COL1A2 PIK3CA PIK3CA GNB4 GNB4 SHC2 SHC2 MAP2K1 MAP2K1 PLCB1 PLCB1 PLCB4 PLCB4 MAPK1 MAPK1 SRC SRC GNAI2 GNAI2 CREB5 CREB5 ATF2 ATF2 MMP9 MMP9 VEGFD VEGFD GNG2 GNG2 SOS2 SOS2 NFKBIA NFKBIA GNAS GNAS ADCY1 ADCY1 ADCY4 ADCY4 PIK3R1 PIK3R1 EGFR EGFR ADCY2 ADCY2 COL4A2 COL4A2 COL4A1 COL4A1 EDNRB EDNRB RXFP2 RXFP2 GNB2 GNB2 SMAD2 SMAD2 TGFB1 TGFB1 RXFP1 RXFP1 MMP1 MMP1 MMP13 MMP13 VEGFC VEGFC GNG8 GNG8 GNGT2 GNGT2 NRAS NRAS GNAI3 GNAI3 PRKACB PRKACB GNG12 GNG12 INSL5 INSL5 PIK3R3 PIK3R3 PIK3CD PIK3CD PRKCZ PRKCZ GNB1 GNB1 JUN JUN RXFP4 RXFP4 PRKACG PRKACG LOC103243499 LOC103243499 RXFP3 RXFP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (535 aa)
ARRB1Arrestin beta 1. (418 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
GNAO1G protein subunit alpha o1. (354 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
PIK3R2Uncharacterized protein. (629 aa)
INSL3IlGF domain-containing protein. (131 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATF4Activating transcription factor 4. (351 aa)
RLN3Relaxin 3. (142 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NOS3Nitric oxide synthase 3. (867 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
SHC3SHC adaptor protein 3. (598 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
EDN1Endothelin 1. (211 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
COL4A5Collagen type IV alpha 5 chain. (882 aa)
RLN2Relaxin 2. (185 aa)
COL4A6Collagen IV NC1 domain-containing protein. (1379 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (363 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GNB3G protein subunit beta 3. (340 aa)
SHC4SHC adaptor protein 4. (630 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (311 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
GNA15G protein subunit alpha 15. (374 aa)
GNB5G protein subunit beta 5. (353 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI1G protein subunit alpha i1. (354 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
COL3A1Collagen type III alpha 1 chain. (878 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNB4G protein subunit beta 4. (340 aa)
SHC2Uncharacterized protein. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SRCTyrosine-protein kinase. (633 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (501 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
GNASUncharacterized protein. (335 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
COL4A2Collagen type IV alpha 2 chain. (1696 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa)
RXFP2Relaxin family peptide receptor 2. (754 aa)
GNB2G protein subunit beta 2. (340 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RXFP1Relaxin family peptide receptor 1. (756 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
INSL5Insulin like 5. (135 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (488 aa)
GNB1G protein subunit beta 1. (340 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RXFP4G_PROTEIN_RECEP_F1_2 domain-containing protein. (373 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
LOC103243499Uncharacterized protein. (251 aa)
RXFP3Relaxin family peptide receptor 3. (469 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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