STRINGSTRING
ARRB1 ARRB1 GNA13 GNA13 PRKCA PRKCA SLC9A3R1 SLC9A3R1 CYP27B1 CYP27B1 PTH PTH MMP15 MMP15 ENSCSAP00000001342 ENSCSAP00000001342 ADCY7 ADCY7 PDE4C PDE4C SP1 SP1 CREB3L1 CREB3L1 MAPK3 MAPK3 ADCY6 ADCY6 ATF4 ATF4 VDR VDR PRKCB PRKCB PLCB3 PLCB3 CASR CASR PLCB2 PLCB2 TRPV5 TRPV5 GCM2 GCM2 PTHLH PTHLH ADCY5 ADCY5 ITPR2 ITPR2 GNAQ GNAQ BRAF BRAF ADCY3 ADCY3 LRP6 LRP6 CREB3L2 CREB3L2 SLC34A1 SLC34A1 LRP5 LRP5 ATF6B ATF6B RXRB RXRB RAF1 RAF1 ADCY9 ADCY9 ITPR3 ITPR3 ADCY8 ADCY8 CREB1 CREB1 CDKN1A CDKN1A MMP24 MMP24 CREB3 CREB3 RXRG RXRG CREB3L3 CREB3L3 ITPR1 ITPR1 FGF23 FGF23 GNA11 GNA11 GNAI1 GNAI1 FOS FOS PLD1 PLD1 HBEGF HBEGF MMP16 MMP16 PLD2 PLD2 EGR1 EGR1 GCM1 GCM1 MAP2K1 MAP2K1 GATA3 GATA3 PLCB1 PLCB1 PLCB4 PLCB4 ARAF ARAF MAPK1 MAPK1 GNAI2 GNAI2 CREB5 CREB5 ATF2 ATF2 RHOA RHOA CYP24A1 CYP24A1 GNAS GNAS RXRA RXRA ADCY1 ADCY1 ADCY4 ADCY4 NR4A2 NR4A2 EGFR EGFR PDE4D PDE4D PTH1R PTH1R MMP14 MMP14 SLC34A3 SLC34A3 SLC34A2 SLC34A2 AKAP13 AKAP13 ADCY2 ADCY2 GNA12 GNA12 TNFSF11 TNFSF11 KL KL BCL2 BCL2 SOST SOST MMP13 MMP13 ARHGEF11 ARHGEF11 MEF2D MEF2D BGLAP BGLAP PRKCG PRKCG MMP17 MMP17 GNAI3 GNAI3 PRKACB PRKACB PDE4B PDE4B NACA2 NACA2 JUND JUND PRKACG PRKACG LOC103243499 LOC103243499 MAFB MAFB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARRB1Arrestin beta 1. (418 aa)
GNA13G protein subunit alpha 13. (377 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
MMP15Matrix metallopeptidase 15. (669 aa)
ENSCSAP00000001342NAC-A/B domain-containing protein. (136 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
PDE4CPhosphodiesterase. (607 aa)
SP1Sp1 transcription factor. (786 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATF4Activating transcription factor 4. (351 aa)
VDRVitamin D receptor. (434 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
CASRCalcium sensing receptor. (882 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (779 aa)
GCM2Glial cells missing transcription factor 2. (506 aa)
PTHLHParathyroid hormone like hormone. (177 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
GNAQG protein subunit alpha q. (301 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
LRP5LDL receptor related protein 5. (1451 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
RXRBRetinoid X receptor beta. (533 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MMP24Matrix metallopeptidase 24. (573 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
RXRGRetinoid X receptor gamma. (463 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (311 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
GNA11G protein subunit alpha 11. (394 aa)
GNAI1G protein subunit alpha i1. (354 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PLD1Phospholipase. (1074 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
PLD2Phospholipase. (960 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GATA3GATA binding protein 3. (443 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (501 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
RHOARas homolog family member A. (193 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa)
GNASUncharacterized protein. (335 aa)
RXRARetinoid X receptor alpha. (462 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PDE4DPhosphodiesterase. (641 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
SLC34A3Solute carrier family 34 member 3. (602 aa)
SLC34A2Solute carrier family 34 member 2. (689 aa)
AKAP13A-kinase anchoring protein 13. (2854 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
GNA12G protein subunit alpha 12. (305 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
KLKlotho. (1010 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SOSTSclerostin. (213 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1569 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MMP17Matrix metallopeptidase 17. (521 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
PDE4BPhosphodiesterase. (517 aa)
NACA2NAC-A/B domain-containing protein. (215 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (348 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
LOC103243499Uncharacterized protein. (251 aa)
MAFBMAF bZIP transcription factor B. (323 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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