STRINGSTRING
SOCS2 SOCS2 MAPK10 MAPK10 ABCC8 ABCC8 PIK3R2 PIK3R2 CACNA1G CACNA1G MAPK3 MAPK3 CACNA1A CACNA1A HKDC1 HKDC1 HK1 HK1 MAPK9 MAPK9 HK3 HK3 ADIPOQ ADIPOQ INS INS MAPK8 MAPK8 PIK3CB PIK3CB CACNA1C CACNA1C SLC2A4 SLC2A4 CACNA1E CACNA1E SLC2A2 SLC2A2 PIK3CA PIK3CA CACNA1D CACNA1D PRKCD PRKCD PRKCE PRKCE MAPK1 MAPK1 IKBKB IKBKB GCK GCK HK2 HK2 PIK3R1 PIK3R1 CACNA1B CACNA1B IRS2 IRS2 PDX1 PDX1 PIK3R3 PIK3R3 MTOR MTOR PIK3CD PIK3CD PRKCZ PRKCZ IRS4 IRS4 MAFA MAFA ENSCSAP00000018170 ENSCSAP00000018170 SOCS1 SOCS1 SOCS3 SOCS3 KCNJ11 KCNJ11 SOCS4 SOCS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOCS2Suppressor of cytokine signaling 2. (198 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
ABCC8ATP binding cassette subfamily C member 8. (1581 aa)
PIK3R2Uncharacterized protein. (629 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2186 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (1363 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (917 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
HK3Hexokinase 3. (923 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CACNA1CCalcium voltage-gated channel subunit alpha1 C. (1898 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2306 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2036 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
GCKPhosphotransferase. (466 aa)
HK2Hexokinase 2. (917 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2342 aa)
IRS2Insulin receptor substrate 2. (906 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (488 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
MAFAMAF bZIP transcription factor A. (352 aa)
ENSCSAP00000018170Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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