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HSD11B2 HSD11B2 PRKCA PRKCA PIK3R2 PIK3R2 MAPK3 MAPK3 PRKCB PRKCB SCNN1B SCNN1B SCNN1G SCNN1G KRAS KRAS INS INS SCNN1A SCNN1A FXYD4 FXYD4 ATP1B1 ATP1B1 SLC9A3R2 SLC9A3R2 PIK3CB PIK3CB ATP1B3 ATP1B3 ATP1B2 ATP1B2 PIK3CA PIK3CA MAPK1 MAPK1 PIK3R1 PIK3R1 SGK1 SGK1 NEDD4L NEDD4L PDPK1 PDPK1 ATP1B4 ATP1B4 ATP1A3 ATP1A3 NR3C2 NR3C2 IGF1 IGF1 FXYD2 FXYD2 ATP1A4 ATP1A4 ATP1A2 ATP1A2 KCNJ1 KCNJ1 PRKCG PRKCG ATP1A1 ATP1A1 PIK3R3 PIK3R3 PIK3CD PIK3CD SFN SFN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (405 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
PIK3R2Uncharacterized protein. (629 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (649 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (669 aa)
FXYD4FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (89 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (265 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (993 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1013 aa)
NR3C2Uncharacterized protein. (587 aa)
IGF1Insulin like growth factor 1. (159 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1029 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (392 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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