STRINGSTRING
GRIN2C GRIN2C GRB2 GRB2 SLC18A2 SLC18A2 H3F3B H3F3B HDAC10 HDAC10 GNAO1 GNAO1 CREB3L1 CREB3L1 HDAC4 HDAC4 MAPK3 MAPK3 ATF4 ATF4 HDAC7 HDAC7 GNG3 GNG3 SHC3 SHC3 NTRK2 NTRK2 ADCY5 ADCY5 KRAS KRAS H2BC5 H2BC5 SLC29A2 SLC29A2 BRAF BRAF MACROH2A2 MACROH2A2 SLC29A3 SLC29A3 GRIN2B GRIN2B GRIN2A GRIN2A ADORA2B ADORA2B PPP1CA PPP1CA CREB3L2 CREB3L2 ATF6B ATF6B ENSCSAP00000005631 ENSCSAP00000005631 ENSCSAP00000005636 ENSCSAP00000005636 H2BW2 H2BW2 HDAC11 HDAC11 DRD1 DRD1 RAF1 RAF1 TH TH CREB1 CREB1 GNB3 GNB3 SHC4 SHC4 CREB3 CREB3 ADORA2A ADORA2A PPP1CB PPP1CB PDYN PDYN CREB3L3 CREB3L3 HRAS HRAS HDAC8 HDAC8 GRIN3A GRIN3A GNB5 GNB5 CALM1 CALM1 GNG7 GNG7 GNAI1 GNAI1 LOC103232061 LOC103232061 GNG10 GNG10 SOS1 SOS1 SLC29A1 SLC29A1 HDAC3 HDAC3 GRIN3B GRIN3B GNG11 GNG11 GNB4 GNB4 SHC2 SHC2 MAP2K1 MAP2K1 HDAC6 HDAC6 PKIA PKIA CALML4 CALML4 CAMKK1 CAMKK1 HDAC9 HDAC9 ARAF ARAF ENSCSAP00000009816 ENSCSAP00000009816 MAPK1 MAPK1 MAOB MAOB MAOA MAOA NPY NPY GNAI2 GNAI2 CREB5 CREB5 ATF2 ATF2 HAT1 HAT1 CAMK4 CAMK4 GNG2 GNG2 SOS2 SOS2 GNAS GNAS HDAC2 HDAC2 H2AZ2 H2AZ2 DDC DDC GRIN1 GRIN1 SLC18A1 SLC18A1 SLC6A3 SLC6A3 GNB2 GNB2 HDAC5 HDAC5 GNG8 GNG8 GRIN2D GRIN2D DRD2 DRD2 PPP1R1B PPP1R1B PPP1CC PPP1CC GNGT2 GNGT2 ENSCSAP00000016053 ENSCSAP00000016053 NRAS NRAS GNAI3 GNAI3 PRKACB PRKACB GNG12 GNG12 HDAC1 HDAC1 GNB1 GNB1 H2AX H2AX LOC103232850 LOC103232850 ENSCSAP00000017607 ENSCSAP00000017607 LOC103229948 LOC103229948 H2BU1 H2BU1 H2AW H2AW H2BC18 H2BC18 H2BC21 H2BC21 H2AC20 H2AC20 H2AC21 H2AC21 LOC103247785 LOC103247785 LOC103247786 LOC103247786 LOC103232262 LOC103232262 ENSCSAP00000017986 ENSCSAP00000017986 PRKACG PRKACG CRH CRH LOC103243499 LOC103243499 LOC103215048 LOC103215048 CALML5 CALML5 CALML3 CALML3 HIST1H2BO HIST1H2BO H3C11 H3C11 H2BC15 H2BC15 HIST1H2AL HIST1H2AL H2BC14 H2BC14 H2AC14 H2AC14 H2BC13 H2BC13 LOC103221972 LOC103221972 H2BC11 H2BC11 H2AC7 H2AC7 H2AC6 H2AC6 H2BC4 H2BC4 H2BC3 H2BC3 LOC103222003 LOC103222003 H2BC1 H2BC1 H2AC1 H2AC1 LOC103221971 LOC103221971 H2AJ H2AJ LOC103221619 LOC103221619 BDNF BDNF LOC103230365 LOC103230365
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1240 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)
HDAC10Histone deacetylase 10. (671 aa)
GNAO1G protein subunit alpha o1. (354 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1088 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ATF4Activating transcription factor 4. (351 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (954 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SHC3SHC adaptor protein 3. (598 aa)
NTRK2Neurotrophic receptor tyrosine kinase 2. (477 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (885 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
SLC29A2Solute carrier family 29 member 2. (456 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
SLC29A3Solute carrier family 29 member 3. (397 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1402 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1327 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ATF6BActivating transcription factor 6 beta. (711 aa)
ENSCSAP00000005631Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
ENSCSAP00000005636Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
H2BW2H2B histone family member M; Belongs to the histone H2B family. (175 aa)
HDAC11Histone deacetylase 11. (347 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (465 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
THTyrosine hydroxylase. (501 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNB3G protein subunit beta 3. (340 aa)
SHC4SHC adaptor protein 4. (630 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PDYNProdynorphin. (253 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (311 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
HDAC8Histone deacetylase 8. (364 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (922 aa)
GNB5G protein subunit beta 5. (353 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI1G protein subunit alpha i1. (354 aa)
LOC103232061Histone domain-containing protein. (136 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (537 aa)
HDAC3Hist_deacetyl domain-containing protein. (266 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1042 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNB4G protein subunit beta 4. (340 aa)
SHC2Uncharacterized protein. (590 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HDAC6Histone deacetylase 6. (1215 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
CALML4Calmodulin like 4. (194 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (505 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (780 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
ENSCSAP00000009816Histone H3; Belongs to the histone H3 family. (136 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MAOBAmine oxidase. (520 aa)
MAOAAmine oxidase. (527 aa)
NPYNeuropeptide Y. (97 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (501 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (614 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
GNASUncharacterized protein. (335 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
DDCDopa decarboxylase. (480 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
GNB2G protein subunit beta 2. (340 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1155 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1336 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
ENSCSAP00000016053Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (497 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
GNB1G protein subunit beta 1. (340 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
LOC103232850Histone H2A; Belongs to the histone H2A family. (115 aa)
ENSCSAP00000017607Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC103229948Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103247785Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103247786Histone H3; Belongs to the histone H3 family. (136 aa)
LOC103232262Histone H3; Belongs to the histone H3 family. (136 aa)
ENSCSAP00000017986Histone domain-containing protein. (136 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
CRHCorticotropin releasing hormone. (196 aa)
LOC103243499Uncharacterized protein. (251 aa)
LOC103215048Histone domain-containing protein. (136 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
H3C11Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2ALHistone H2A; Belongs to the histone H2A family. (130 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC14Histone H2A; Belongs to the histone H2A family. (128 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103221972Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
H2BC4Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103222003Histone H2A; Belongs to the histone H2A family. (130 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
LOC103221971Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
LOC103221619Histone domain-containing protein. (136 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa)
LOC103230365Histone H3; Belongs to the histone H3 family. (136 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (20%) [HD]