STRINGSTRING
IL2 IL2 AKT2 AKT2 ACE ACE NFKB1 NFKB1 IFNG IFNG MAPK10 MAPK10 PPP2R2D PPP2R2D CXCL8 CXCL8 MAPK11 MAPK11 GNAO1 GNAO1 PIK3R2 PIK3R2 TRAF6 TRAF6 CHUK CHUK CCL3 CCL3 MAPK3 MAPK3 CCL5 CCL5 CCL2 CCL2 CALR CALR IKBKG IKBKG IRAK4 IRAK4 IRAK1 IRAK1 PLCB3 PLCB3 PLCB2 PLCB2 NOS2 NOS2 GNAQ GNAQ GNA14 GNA14 ENSCSAP00000004095 ENSCSAP00000004095 RELA RELA MAPK9 MAPK9 MAP2K4 MAP2K4 KNG1 KNG1 AKT3 AKT3 FADD FADD TGFBR2 TGFBR2 AKT1 AKT1 IFNGR2 IFNGR2 MAPK8 MAPK8 MAPK14 MAPK14 MAPK13 MAPK13 IL12B IL12B BDKRB2 BDKRB2 TNFRSF1A TNFRSF1A CASP8 CASP8 CFLAR CFLAR CD247 CD247 TGFBR1 TGFBR1 PIK3CB PIK3CB GNA15 GNA15 GNA11 GNA11 FASLG FASLG GNAI1 GNAI1 TGFB3 TGFB3 FOS FOS IL12A IL12A PPP2R2B PPP2R2B PIK3CA PIK3CA TLR4 TLR4 PLCB1 PLCB1 PLCB4 PLCB4 PPP2CA PPP2CA MAPK1 MAPK1 LOC103227720 LOC103227720 IL6 IL6 GNAI2 GNAI2 MYD88 MYD88 IL10 IL10 IKBKB IKBKB NFKBIA NFKBIA GNAS GNAS ADCY1 ADCY1 PPP2CB PPP2CB PIK3R1 PIK3R1 PPP2R2A PPP2R2A PPP2R2C PPP2R2C IL1B IL1B IFNGR1 IFNGR1 GNAL GNAL SERPINE1 SERPINE1 SMAD2 SMAD2 TGFB1 TGFB1 PPP2R1B PPP2R1B CD3E CD3E CD3D CD3D CD3G CD3G PPP2R1A PPP2R1A GNAI3 GNAI3 PIK3R3 PIK3R3 C1QB C1QB C1QC C1QC PIK3CD PIK3CD IFNB1 IFNB1 TLR2 TLR2 JUN JUN LOC103243499 LOC103243499 TICAM1 TICAM1 TLR6 TLR6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
ACEAngiotensin-converting enzyme. (1040 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (458 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
GNAO1G protein subunit alpha o1. (354 aa)
PIK3R2Uncharacterized protein. (629 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CCL3C-C motif chemokine. (92 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CCL5C-C motif chemokine. (91 aa)
CCL2C-C motif chemokine. (99 aa)
CALRCalreticulin. (417 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (686 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
GNAQG protein subunit alpha q. (301 aa)
GNA14G protein subunit alpha 14. (355 aa)
ENSCSAP00000004095Ig-like domain-containing protein. (166 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (363 aa)
KNG1Kininogen 1. (427 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
FADDDED domain-containing protein. (189 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IFNGR2Interferon gamma receptor 2. (341 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (341 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (496 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
CD247CD247 molecule. (165 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
GNA15G protein subunit alpha 15. (374 aa)
GNA11G protein subunit alpha 11. (394 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (282 aa)
GNAI1G protein subunit alpha i1. (354 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LOC103227720TIR domain-containing protein. (1032 aa)
IL6Interleukin 6. (212 aa)
GNAI2G protein subunit alpha i2. (355 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
IL10Interleukin 10. (178 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
GNASUncharacterized protein. (335 aa)
ADCY1Adenylate cyclase 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
IFNGR1Interferon gamma receptor 1. (491 aa)
GNALG protein subunit alpha L. (381 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (599 aa)
CD3ECD3e molecule. (197 aa)
CD3DCD3d molecule. (171 aa)
CD3GCD3g molecule. (209 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
C1QBComplement C1q B chain. (253 aa)
C1QCComplement C1q C chain. (245 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IFNB1Interferon beta 1. (187 aa)
TLR2Toll-like receptor. (784 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
LOC103243499Uncharacterized protein. (251 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (711 aa)
TLR6Toll-like receptor. (796 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.