STRINGSTRING
PECAM1 PECAM1 HBB HBB IFNG IFNG CXCL8 CXCL8 LRP1 LRP1 COMP COMP CCL2 CCL2 THBS1 THBS1 ICAM1 ICAM1 CD40LG CD40LG ITGB2 ITGB2 ENSCSAP00000004095 ENSCSAP00000004095 SDC1 SDC1 KLRK1 KLRK1 KLRB1 KLRB1 MET MET SELP SELP SELE SELE CD36 CD36 HGF HGF TGFB3 TGFB3 IL12A IL12A HBA HBA TLR4 TLR4 LOC103227720 LOC103227720 IL6 IL6 MYD88 MYD88 CD40 CD40 IL10 IL10 THBS4 THBS4 IL1B IL1B TGFB1 TGFB1 IL18 IL18 CSF3 CSF3 THBS3 THBS3 VCAM1 VCAM1 TLR2 TLR2 ACKR1 ACKR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
HBBGLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
LRP1LDL receptor related protein 1. (4544 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
CCL2C-C motif chemokine. (99 aa)
THBS1Thrombospondin 1. (1170 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
ITGB2Integrin beta. (784 aa)
ENSCSAP00000004095Ig-like domain-containing protein. (166 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
KLRK1Killer cell lectin like receptor K1. (216 aa)
KLRB1Killer cell lectin like receptor B1. (225 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
SELPSelectin P. (830 aa)
SELESelectin E. (610 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
HBAGLOBIN domain-containing protein; Belongs to the globin family. (142 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
LOC103227720TIR domain-containing protein. (1032 aa)
IL6Interleukin 6. (212 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
CD40CD40 molecule. (278 aa)
IL10Interleukin 10. (178 aa)
THBS4Thrombospondin 4. (870 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CSF3Colony stimulating factor 3. (207 aa)
THBS3Thrombospondin 3. (947 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
TLR2Toll-like receptor. (784 aa)
ACKR1Atypical chemokine receptor 1 (Duffy blood group). (338 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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