STRINGSTRING
TRADD TRADD AKT2 AKT2 PAK1 PAK1 PAK4 PAK4 NFKB1 NFKB1 NFATC3 NFATC3 PPP3CA PPP3CA PRKCA PRKCA AP1G1 AP1G1 TRIM5 TRIM5 MAPK10 MAPK10 MAP2K6 MAP2K6 TBK1 TBK1 WEE1 WEE1 MAPK11 MAPK11 GNAO1 GNAO1 PIK3R2 PIK3R2 TRAF6 TRAF6 BTRC BTRC BST2 BST2 CHUK CHUK AP1M1 AP1M1 RBX1 RBX1 RPS6KB1 RPS6KB1 MAPK3 MAPK3 TAB1 TAB1 APOBEC3G APOBEC3G DDB1 DDB1 APOBEC3C APOBEC3C APOBEC3B APOBEC3B CALR CALR PRKCB PRKCB GNG3 GNG3 IKBKG IKBKG IRAK4 IRAK4 IRAK1 IRAK1 CUL1 CUL1 AP1M2 AP1M2 BAD BAD RIPK1 RIPK1 PAK6 PAK6 RAC2 RAC2 MAP2K3 MAP2K3 ITPR2 ITPR2 GNAQ GNAQ AP1S3 AP1S3 KRAS KRAS ENSCSAP00000004095 ENSCSAP00000004095 RELA RELA HLA-F HLA-F Chsa-A Chsa-A WEE2 WEE2 MAP2K7 MAP2K7 MAPK9 MAPK9 Chsa-B Chsa-B LIMK2 LIMK2 PPP3CB PPP3CB PAK3 PAK3 AKT3 AKT3 FADD FADD PDIA3 PDIA3 TAPBP TAPBP BAK1 BAK1 B2M B2M RAF1 RAF1 FBXW11 FBXW11 ITPR3 ITPR3 IFNA2 IFNA2 IFNA8 IFNA8 AKT1 AKT1 AP1B1 AP1B1 SAMHD1 SAMHD1 MAPK8 MAPK8 MAPK14 MAPK14 MAPK13 MAPK13 GNB3 GNB3 CD4 CD4 ELOB ELOB TNFRSF1A TNFRSF1A MAP2K2 MAP2K2 CASP8 CASP8 CD247 CD247 ITPR1 ITPR1 HRAS HRAS PIK3CB PIK3CB RNF7 RNF7 GNA11 GNA11 ATR ATR GNB5 GNB5 CALM1 CALM1 GNG7 GNG7 FASLG FASLG GNAI1 GNAI1 CCNB2 CCNB2 FOS FOS GNG10 GNG10 GNG11 GNG11 CCNB3 CCNB3 BCL2L1 BCL2L1 PIK3CA PIK3CA GNB4 GNB4 STING1 STING1 TLR4 TLR4 MAP2K1 MAP2K1 CRKL CRKL CALML4 CALML4 ELOC ELOC PAK5 PAK5 SKP1 SKP1 MAPK1 MAPK1 PLCG1 PLCG1 CGAS CGAS DCAF1 DCAF1 CRK CRK GNAI2 GNAI2 MYD88 MYD88 AP1S2 AP1S2 PPP3R1 PPP3R1 IKBKB IKBKB GNG2 GNG2 NFATC2 NFATC2 TRAF5 TRAF5 NFKBIA NFKBIA CFL2 CFL2 NFATC4 NFATC4 CCNB1 CCNB1 PIK3R1 PIK3R1 PTK2B PTK2B TRAF2 TRAF2 CXCR4 CXCR4 TAB2 TAB2 MAP3K7 MAP3K7 CUL4A CUL4A GNB2 GNB2 AP1S1 AP1S1 BCL2 BCL2 LIMK1 LIMK1 NFATC1 NFATC1 LOC103247147 LOC103247147 CUL4B CUL4B ENSCSAP00000014407 ENSCSAP00000014407 PLCG2 PLCG2 GNG8 GNG8 CUL5 CUL5 CASP3 CASP3 ATM ATM BAX BAX CD3E CD3E CD3D CD3D CD3G CD3G IRF3 IRF3 GNGT2 GNGT2 CHEK1 CHEK1 PXN PXN RAC3 RAC3 PRKCG PRKCG NRAS NRAS GNAI3 GNAI3 GNG12 GNG12 PIK3R3 PIK3R3 TNFRSF1B TNFRSF1B MTOR MTOR PIK3CD PIK3CD GNB1 GNB1 CDK1 CDK1 ENSCSAP00000017563 ENSCSAP00000017563 ENSCSAP00000017564 ENSCSAP00000017564 IFNA6 IFNA6 IFNA14 IFNA14 ENSCSAP00000017567 ENSCSAP00000017567 ENSCSAP00000017568 ENSCSAP00000017568 ENSCSAP00000017569 ENSCSAP00000017569 IFNB1 IFNB1 TLR2 TLR2 JUN JUN LOC103224743 LOC103224743 CCR5 CCR5 CALML5 CALML5 CALML3 CALML3 ENSCSAP00000018734 ENSCSAP00000018734 ENSCSAP00000018835 ENSCSAP00000018835
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRADDTNFRSF1A associated via death domain. (308 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PAK4Non-specific serine/threonine protein kinase. (633 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
NFATC3RHD domain-containing protein. (637 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
AP1G1AP-1 complex subunit gamma. (822 aa)
TRIM5Uncharacterized protein. (515 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TBK1TANK binding kinase 1. (729 aa)
WEE1Wee1-like protein kinase. (646 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
GNAO1G protein subunit alpha o1. (354 aa)
PIK3R2Uncharacterized protein. (629 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
BST2Bone marrow stromal cell antigen 2. (182 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
RBX1Ring-box 1. (108 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (338 aa)
APOBEC3GApolipoprotein B mRNA editing enzyme catalytic subunit 3G. (403 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
APOBEC3CApolipoprotein B mRNA editing enzyme catalytic subunit 3C. (190 aa)
APOBEC3BUncharacterized protein. (490 aa)
CALRCalreticulin. (417 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (686 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (355 aa)
BADBCL2 associated agonist of cell death. (167 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
RAC2Rac family small GTPase 2. (192 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
GNAQG protein subunit alpha q. (301 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSCSAP00000004095Ig-like domain-containing protein. (166 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (348 aa)
Chsa-AMHC class IA antigen; Belongs to the MHC class I family. (365 aa)
WEE2Wee1-like protein kinase. (567 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
Chsa-BIg-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
LIMK2LIM domain kinase 2. (638 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
FADDDED domain-containing protein. (189 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
TAPBPTAP binding protein. (504 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
FBXW11F-box and WD repeat domain containing 11. (510 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
IFNA2Interferon alpha 2. (190 aa)
IFNA8Interferon alpha 8. (195 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AP1B1AP complex subunit beta. (949 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GNB3G protein subunit beta 3. (340 aa)
CD4CD4 molecule. (560 aa)
ELOBUbiquitin-like domain-containing protein. (118 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (496 aa)
CD247CD247 molecule. (165 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RNF7Ring finger protein 7. (113 aa)
GNA11G protein subunit alpha 11. (394 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
GNB5G protein subunit beta 5. (353 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (282 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1324 aa)
BCL2L1BCL2 like 1. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNB4G protein subunit beta 4. (340 aa)
STING1Transmembrane protein 173. (379 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CALML4Calmodulin like 4. (194 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
CGASCyclic GMP-AMP synthase. (526 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1507 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
GNAI2G protein subunit alpha i2. (355 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (202 aa)
PPP3R1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
NFATC2Nuclear factor of activated T cells 2. (928 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (429 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
TRAF2TNF receptor-associated factor. (449 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
GNB2G protein subunit beta 2. (340 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LIMK1LIM domain kinase 1. (647 aa)
NFATC1Nuclear factor of activated T cells 1. (929 aa)
LOC103247147Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
CUL4BCullin 4B; Belongs to the cullin family. (900 aa)
ENSCSAP00000014407CMP/dCMP-type deaminase domain-containing protein. (209 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CUL5Cullin 5; Belongs to the cullin family. (780 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CD3ECD3e molecule. (197 aa)
CD3DCD3d molecule. (171 aa)
CD3GCD3g molecule. (209 aa)
IRF3Interferon regulatory factor 3. (422 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CHEK1Checkpoint kinase 1. (749 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (591 aa)
RAC3Rac family small GTPase 3. (192 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GNB1G protein subunit beta 1. (340 aa)
CDK1Protein kinase domain-containing protein. (297 aa)
ENSCSAP00000017563Uncharacterized protein. (189 aa)
ENSCSAP00000017564Uncharacterized protein. (189 aa)
IFNA6Interferon alpha 6. (189 aa)
IFNA14Interferon alpha 14. (189 aa)
ENSCSAP00000017567Uncharacterized protein. (189 aa)
ENSCSAP00000017568Uncharacterized protein. (189 aa)
ENSCSAP00000017569Uncharacterized protein. (189 aa)
IFNB1Interferon beta 1. (187 aa)
TLR2Toll-like receptor. (784 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
LOC103224743ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (166 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
CALML5Calmodulin like 5. (146 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ENSCSAP00000018734Ubiquitin-like domain-containing protein. (118 aa)
ENSCSAP00000018835Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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