STRINGSTRING
FGF2 FGF2 DCN DCN WNT9B WNT9B LUM LUM WNT3 WNT3 AKT2 AKT2 ANK2 ANK2 ITGB3 ITGB3 PAK1 PAK1 PPP1R12A PPP1R12A DDX5 DDX5 PRKCA PRKCA FRS2 FRS2 MDM2 MDM2 HPSE HPSE RRAS2 RRAS2 GRB2 GRB2 MAPK11 MAPK11 KDR KDR PDCD4 PDCD4 COL1A1 COL1A1 ERBB3 ERBB3 MMP2 MMP2 CD63 CD63 WNT7B WNT7B PIK3R2 PIK3R2 ITGA5 ITGA5 EIF4B EIF4B WNT8B WNT8B HPSE2 HPSE2 RPS6KB1 RPS6KB1 GPC1 GPC1 MAPK3 MAPK3 PLCE1 PLCE1 WNT1 WNT1 WNT10B WNT10B PTCH1 PTCH1 SHH SHH PRKCB PRKCB FLNA FLNA THBS1 THBS1 HCLS1 HCLS1 ROCK2 ROCK2 VTN VTN ANK3 ANK3 CTSL CTSL ITPR2 ITPR2 KRAS KRAS ITGB5 ITGB5 GPC3 GPC3 SDC1 SDC1 BRAF BRAF TIMP3 TIMP3 IHH IHH PPP1CA PPP1CA WNT10A WNT10A WNT6 WNT6 CAMK2G CAMK2G PLAU PLAU NUDT16L1 NUDT16L1 VAV1 VAV1 CCND1 CCND1 AKT3 AKT3 CTTN CTTN RPS6 RPS6 ERBB4 ERBB4 TIAM1 TIAM1 WNT7A WNT7A TFAP4 TFAP4 RAF1 RAF1 ITPR3 ITPR3 AKT1 AKT1 NANOG NANOG IGF2 IGF2 SMO SMO FLNC FLNC MYC MYC PTPN6 PTPN6 MAPK14 MAPK14 MAPK13 MAPK13 CDKN1A CDKN1A IL12B IL12B WNT16 WNT16 PPP1CB PPP1CB MAP2K2 MAP2K2 CAV3 CAV3 WNT2 WNT2 MET MET CAV1 CAV1 CAV2 CAV2 ITPR1 ITPR1 MRAS MRAS HRAS HRAS PIK3CB PIK3CB TP53 TP53 ITGB1 ITGB1 CAMK2A CAMK2A WNT5B WNT5B FASLG FASLG FZD6 FZD6 HGF HGF MSN MSN VEGFA VEGFA FLNB FLNB SOS1 SOS1 ITGAV ITGAV EZR EZR COL1A2 COL1A2 WNT5A WNT5A HBEGF HBEGF PIK3CA PIK3CA TLR4 TLR4 MAP2K1 MAP2K1 WNT8A WNT8A ELK1 ELK1 ARAF ARAF MAPK1 MAPK1 SRC SRC PLCG1 PLCG1 HIF1A HIF1A ESR1 ESR1 SDC4 SDC4 HOXD10 HOXD10 MMP9 MMP9 ANK1 ANK1 RHOA RHOA SOS2 SOS2 VAV2 VAV2 CAMK2B CAMK2B PIK3R1 PIK3R1 FZD3 FZD3 EGFR EGFR WNT9A WNT9A WNT3A WNT3A ITGA2 ITGA2 CTNNB1 CTNNB1 IGF1R IGF1R IQGAP1 IQGAP1 DROSHA DROSHA ROCK1 ROCK1 SMAD2 SMAD2 PDPK1 PDPK1 ENSCSAP00000014297 ENSCSAP00000014297 FZD4 FZD4 TGFB1 TGFB1 GAB1 GAB1 PLCG2 PLCG2 IGF1 IGF1 STAT3 STAT3 CASP3 CASP3 RDX RDX HSPB2 HSPB2 ERBB2 ERBB2 PPP1CC PPP1CC CBL CBL RRAS RRAS PTPN11 PTPN11 ARHGEF12 ARHGEF12 PXN PXN PRKCG PRKCG PPP1R12C PPP1R12C NRAS NRAS WNT2B WNT2B VAV3 VAV3 PRKACB PRKACB PIK3R3 PIK3R3 SLC9A1 SLC9A1 WNT4 WNT4 CDC42 CDC42 HSPG2 HSPG2 MTOR MTOR PIK3CD PIK3CD TLR2 TLR2 PRKACG PRKACG FZD7 FZD7 FZD5 FZD5 TWIST2 TWIST2 FZD10 FZD10 NANOGP8 NANOGP8 FZD2 FZD2 FZD1 FZD1 FZD9 FZD9 TWIST1 TWIST1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LUMLumican. (338 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
AKT2Non-specific serine/threonine protein kinase. (535 aa)
ANK2Ankyrin 2. (4035 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (942 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
HPSEHeparanase. (546 aa)
RRAS2RAS related 2. (204 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PDCD4Programmed cell death 4. (469 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1342 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
CD63Tetraspanin. (238 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PIK3R2Uncharacterized protein. (629 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
EIF4BEukaryotic translation initiation factor 4B. (611 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
HPSE2Uncharacterized protein. (120 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PLCE1Phosphoinositide phospholipase C. (2317 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PTCH1Patched 1. (1452 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
FLNAFilamin A. (2639 aa)
THBS1Thrombospondin 1. (1170 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (497 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
VTNSMB domain-containing protein. (478 aa)
ANK3Ankyrin 3. (2797 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
GPC3Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (452 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (588 aa)
PLAUPlasminogen activator, urokinase. (437 aa)
NUDT16L1Nudix hydrolase 16 like 1. (225 aa)
VAV1Vav guanine nucleotide exchange factor 1. (719 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
CTTNCortactin. (550 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (266 aa)
ERBB4Protein kinase domain-containing protein. (622 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1466 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
TFAP4Transcription factor AP-4. (338 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NANOGNanog homeobox. (305 aa)
IGF2Insulin like growth factor 2. (236 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
FLNCFilamin C. (2725 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (341 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (282 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
MSNMoesin. (577 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
FLNBFilamin B. (2602 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
EZREzrin. (584 aa)
COL1A2Collagen type I alpha 2 chain. (1274 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ELK1Uncharacterized protein. (296 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SRCTyrosine-protein kinase. (633 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ESR1Estrogen receptor 1. (487 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
HOXD10Homeobox D10. (340 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
ANK1Ankyrin 1. (1920 aa)
RHOARas homolog family member A. (193 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
VAV2Vav guanine nucleotide exchange factor 2. (896 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (628 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (295 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
CTNNB1Catenin beta 1. (781 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
DROSHADrosha ribonuclease III. (1379 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
ENSCSAP00000014297Uncharacterized protein; Belongs to the peptidase C1 family. (262 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IGF1Insulin like growth factor 1. (159 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
RDXRadixin. (605 aa)
HSPB2SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (182 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
CBLCbl proto-oncogene. (907 aa)
RRASRAS related. (218 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (591 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (786 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (347 aa)
VAV3Vav guanine nucleotide exchange factor 3. (782 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (354 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
CDC42Cell division cycle 42. (191 aa)
HSPG2Heparan sulfate proteoglycan 2. (4391 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TLR2Toll-like receptor. (784 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (350 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TWIST2Twist family bHLH transcription factor 2. (160 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
NANOGP8Nanog homeobox retrogene P8. (305 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
TWIST1Twist family bHLH transcription factor 1. (200 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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